Approved Projects on the 3T Philips Scanner (RRID: SCR_025374)
| Study | PI | Department | Year | |
|---|---|---|---|---|
| MRI, Fast Localizer (3 Plane) | mRNA-1195-P2001 - Site# CA001. A Phase 2, Randomized, Observer-Blind, Placebo-Controlled, Dose-Ranging Study of mRNA-1195 Intramuscular Injection in Participants 18 to ≤55 Years of Age With Early Multiple Sclerosis. This is a Phase 2, Randomized, Observer-Blind, Placebo-Controlled, Dose-Ranging Study of mRNA-1195 Intramuscular Injection in Participants 18 to ≤55 Years of Age with Early Multiple Sclerosis sponsored by Moderna. The main goals of this study are to develop a new vaccine for the prevention of relapses of MS, evaluate the safety of mRNA-1195 and any potential side effects, measure its effectiveness in preventing MS relapses, assess its impact on the Epstein-Barr Virus, and explore how genetics may be related to the illness https://clinicaltrials.gov/study/NCT06735248#studyoverview | Robert Carruthers | MS & NMO Clinical Trials Group | 2025 |
| MRI, FLAIR, DTI, rs-fMRI, Single Echo | ASTEROID- Gamifying neuro rehabilitation, can we predict who will benefit? The goal of the proposed work is to determine whether neurobiology predicts response to gamified arm rehabilitation delivered in the late subacute phase of stroke recovery. Importantly, our data will enable personalization of interventions after stroke. www.brain.rehab.med.ubc.ca | Lara Boyd | Physical Therapy | 2025 |
| MRI, FLAIR, DTI, QRM, Sodium multi-nuc | GAMBIT: Global Assessment of Markers for progression including Blood, Imaging, and clinical Tests. GAMBIT is a pilot study to assess imaging and serologic biomarkers for progression of Multiple Sclerosis (MS), in part to establish a MS Biomarker Program for assessing neuroprotection and remyelination therapies in early phase clinical trials. Over the 24-month study period, brain MRI (magnetic resonance imaging), clinical, and blood biomarker measurements will be collected. The primary objective of this study is to evaluate the association of blood and imaging biomarkers with clinical measurements and outcomes, to establish suitable biomarkers for future clinical trials that can better assess the effects of investigational products in the treatment of MS. | Tony Traboulsee | MS & NMO Clinical Trials Group | 2025 |
| MRI, Single Echo, tb-fMRI, rs-fMRI | SCANS- Spontaneous Craving and Neurophenomenology in Smokers, 25-002, This study examines brain activity underlying spontaneous (i.e., not cued or externally triggered) craving in cigarette smokers. We will present participants with craving probes in an fMRI scanner while they watch a non-smoking related film. Brain activation between high vs low craving will be assessed to explore brain patterns of first-person-craving as it arises spontaneously. | Christian Schutz | Psychiatry | 2025 |
| MRI, tb-fMRI, Single Echo, MB-SENSE | Meaning media moments: using self-selected films to investigate meaningful experiences. At certain times we experience events in our lives as trivial and unimportant, while at other times very personally meaningful. This study will be the first to identify the neural correlates of this dimension of experience. Participants will undergo MRI scanning while watching clips from movies that they self-select as meaningful, afterwards self-reporting on the contents of their experience Lab website: https://www.christofflab.ca/ | Kalina Christoff Hadjiilieva | Psychology | 2025 |
| MRI | Biomechanical and Imaging Assessments of Hip Microinstability. In hip microinstability, individuals have hip pain that seems to be caused by a loose and unsteady hip joint. It is important to understand microinstability better because it may cause hip osteoarthritis and require joint replacement. We will investigate if there are early signs of cartilage degeneration in hips that are unstable to better understand of how microinstability affects the hip, which will help surgeons identify patients and plan surgery to protect hips. | David Wilson | Engineering | 2024 |
| MRI, rs-fMRI, DTI | ENABLE - Enabling Neuroscience research Approaches for Brain, feeLings and Emotions (ENABLE): An Innovative Platform for Clinical Trials in Mood Disorders. A clinical trials registry open to any patients fluent in English, 19 years or older, and meeting DSM-5 criteria for bipolar or depressive disorders. There will be a single instance of data collection (clinical interviews, self-report questionnaires) and optionally EEG & MRI. The registry will support biomarkers research and future clinical trials recruitment. | Raymond Lam | Psychiatry | 2024 |
| MRI, rs-fMRI, DTI | The bWell Cognitive Care Platform: a pilot feasibility study in patients with depression. Although individuals with depression often suffer from cognitive deficits such as problems with memory, attention and processing speed, we lack effective treatments and effective ways to assess and measure cognitive performance in real-world environments. The goal of this clinical trial is to determine the acceptability, feasibility, and validity of the bWell Cognitive Care Platform for Depression (bWell-D), a novel Virtual Reality (VR) cognitive assessment and remediation tool, in depressed populations. Patients will complete various cognitive/functional/clinical assessments and questionnaires, as well as EEGs and MRI scans to examine brain-based measures of cognitive change. | Trisha Chakrabarty | Psychiatry | 2024 |
| MRI, Sodium multi-nuc (FLORET) | Reproducibility of Sodium MRI with FLORET UTE. The goal of this study is to test the reproducibility of quantitative sodium MRI acquired with the latest Fermat looped orthogonally encoded trajectories (FLORET) 3D ultrashort echo (UTE) sequence. The latest release of FLORET UTE has implemented gradient frequency limitations to improve k-space trajectories for improved SNR. The ultimate impact of this study will be to reduce the scan time of sodium MRI to increase the clinical feasibility of this new technique for future application to investigations of neurological disease and brain injury. | Rebecca Feldman | Medical Physics | 2024 |
| MRI, tb-fMRI, Single Echo | Investigating the Dynamics of Thought using Brain Connectivity and Experience Sampling. This study examines different aspects of the dynamics and content of ongoing thought. To do this, we will present subjects with thought probes related to their thought dynamics and the modality of their thought in the fMRI scanner. We will investigate the relationship between participant’s responses and large scale brain network dynamics. | Kalina Christoff | Psychology | 2024 |
| MRI | LSML- resistance training. Determining the effect of muscle length at peak force on resistance training induced hypertrophy. An investigation of muscle growth and strength when force is manipulated at either a more stretched or contracted muscle position during resistance exercise. | Cameron Mitchell | Kinesiology/ Fac. Of Education | 2024 |
| MRI, rs-fMRI; tb-fMRI | From Episodic Memory to Functioning in Schizophrenia and Related Psychoses: A Neurocognitive Model (Cog-MP). Memory is an important predictor of how well individuals affected by schizophrenia and related psychoses are able function in their social and occupational lives. However, the exact structures and functions in the brain responsible for this relationship are currently unknown. Using MRI and various clinical and behavioural measures, we aim to identify relations between brain regions, memory, and functional outcomes in schizophrenia and related psychoses. | Todd Woodward | Psychiatry | 2024 |
| MRI, rs-fMRI, tb-fMRI, DTI, UTE, Single Echo, MRS, Single voxel Spectroscopy | LIFUS2 - Low Intensity Focused Ultrasound Stimulation for Parkinson’s Disease Treatment. Therapies to treat Parkinson’s disease are lacking - the newly-developed method of low intensity focused ultrasound stimulation (LIFUS) holds great promise as a novel approach to brain stimulation due to its non-invasive nature and its spatial precision. The effects of even brief sonification may last several hours due to its ability to module activity within deep structures of the brain. This project aims to develop a safe therapy to treat motor symptoms of Parkinson's disease using LIFUS. | Martin McKeown | Neurology, Pacific Parkinson's Research Institute | 2024 |
| MRI, FLAIR | Sanofi - LTS17043. GEMINI/ PERSEUS extension study. | Virginia Devonshire | MS & NMO Clinical Trials Group | 2024 |
| MRI, DTI, tb-fMRI, QRM, Single Echo, MWF | Investigating imagery representations associated with physical and visual experience. The aim of this work is to understand processes which contribute to the development motor imagery ability. While motor imagery – imagining how performing a movement looks and feels – is an effective psychological and behavioural intervention, little is known about how perceptual and motor experience contribute to its development and use. By employing functional magnetic resonance imaging during a motor imagery task pre and post a bout of practice, the current study will examine how visual and physical experiences shape our motor imagery ability. | Sarah Kraeutner | Psychology | 2024 |
| MRI | VERTEX - A Phase 1/2 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-264 in Subjects With Type 1 Diabetes Mellitus (Protocol # VX22-264-101). This study is investigating if experimental devices implanted in the preperitoneal space can reduce or eliminate the need for individuals with Type 1 diabetes mellitus to take insulin. | David Thompson | Endocrinology | 2024 |
| MRI, DTI, rs-fMRI, UFE, FGATIR | Effectiveness of targeting the Zona Incerta (ZI) for tremor control in Parkinson's disease patients. We propose that direct neuromodulation of the Zona Incerta (ZI) using low-intensity ultrasound (LIFU) could yield effects similar to Magnetic Resonance-guided Focused Ultrasound (MRgFUS) ventral intermediate nucleus (Vim) thalamotomy for tremor control in Parkinson's disease (PD). The specific aims involve evaluating the ZI as a potential target for tremor suppression, comparing its effectiveness to targeting the Vim, and investigating the functional mechanisms of ZI-LIFU and Vim-LIFU. The research plan outlines recruiting 20 PD participants for a crossover randomized controlled trial with the order of stimulation types (ZI-LIFU/Vim-LIFU) randomized across two study groups. | Martin McKeown | Neurology | 2024 |
| MRI, SWI | FREVIVA - A randomized, double-blind, Phase 3 study comparing efficacy and safety of frexalimab (SAR441344), EFC17504, to placebo in adult participants with nonrelapsing secondary progressive multiple sclerosis. A randomized, double-blind, Phase 3 study comparing efficacy and safety of frexalimab (SAR441344) to placebo in adult participants with nonrelapsing secondary progressive multiple sclerosis. | Virginia Devonshire | Neurology | 2024 |
| MRI, FLAIR | FREXALT - Master protocol of two independent, randomized, double-blind Phase 3 studies comparing efficacy and safety of frexalimab (SAR441344), EFC17919, to teriflunomide in adult participants with relapsing forms of multiple sclerosis. The purpose of this study is to measure the annualized relapse rate (ARR) with administration of frexalimab compared to a daily oral dose of teriflunomide in male and female participants with relapsing forms of multiple sclerosis. | Alice Schabas | Neurology | 2024 |
| MRI, DTI, FLAIR, rs-fMRI | Simulating brain tumor resection to optimize onco-functional balance in low-grade glioma. We are assessing the relationship between personalized whole brain dynamical models and cognitive outcomes in patients with Low-Grade Gliomas. | Stefan Lang | Neurosurgery | 2024 |
| MRI, DTI, rs-fMRI | Simultaneous deep brain stimulation and fMRI. We are performing simultaneous deep brain stimulation and functional MRI. This technique will allow us to investigate the network basis of deep brain stimulation. | Stefan Lang | Neurosurgery | 2024 |
| MRI, SWI, FLAIR | A Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with primary progressive multiple sclerosis (PERSEUS). This study will evaluate the efficacy of SAR442168 compared to placebo in delaying disability progression in PPMS and on clinical endpoints such as MRI lesions, cognitive performance, physical function, and quality of life. | Alice Schabas | Neurology | 2024 |
| MRI, DWI, MRE | A Phase 2a, Randomized, Placebo-contolled, Double-blind Study to Assess the Safety, Pharmacokinetics, Pharmacodynamicz of AGMB-129 in Patients with Fibrostetonic Crohn’s Disease. The study evaluates the safety and biological activity of an experimental product called “AGMB-129” in patients with fibrostenotic Crohn’s Disease. This is a type of CD where there is fibrosis or scarring on the internal surface of bowels that results in narrowing of the bowel. | Brian Bressler | Gastroenterology | 2024 |
| MRI, QRM, rs-fMRI | SOAR - The Stop Osteoarthritis (SOAR) Hybrid Effectiveness-Implementation Type 1 Randomized Controlled Trial for Young People at-High-Risk of Early Onset Knee Osteoarthritis. In this study, people who have torn the Anterior Cruciate ligament in their knee and had reconstruction surgery 8-36 months previously will be randomized to receive either the SOAR program or not. Researchers will test if those who receive the SOAR program have greater gains in knee health, including pain, symptoms, function, and quality-of-life at 6, 12, and 24 months, compared to those who do not. Researchers will also use MRI to assess for changes in the knee cartilage in both groups to see how SOAR influences structural OA. | Jackie Whittaker | Physical Therapy | 2023 |
| MRI, FLAIR, DTI, Magnetization Transfer, QRM, SWI | AMBRA - Assessment of Microstructural Brain Alterations. Assessment of myelin content and tissue microstructure in multiple sclerosis: a repeated MRI study. AMBRA is a pilot study across 6 universities internationally working to implement and evaluate a harmonized MRI protocol optimized to assess myelin across multiple scanner platforms. In combination with fluid biomarkers, the goal is to be able to create an MRI protocol that could be implemented in clinical trials for multiple sclerosis (MS) that would be sensitive to changes in myelin as a result of pathology and treatment response. | Shannon Kolind | Neurology | 2023 |
| MRI, FLAIR, DWI, Angiography, QRM, Perfusion- ASL, SWI | Hotel-TANDEM study - (Hotel Phase 3) - Traumatic brain injury and cerebral small vessel disease in a vulnerably housed cohort, a prelude to early neurodegeneration and dementia. Hotel-TANDEM is the third phase of our longitudinal investigation of the intersection of mental illness, addiction and traumatic brain injury. This phase of research will be focused on exploring the trajectories of cognitive functioning in relation to traumatic brain injuries in a vulnerable population with high rates of cerebrovascular deficits, comorbid addiction, mental illness and overdose, in the context of aging. | Will Panenka, Donna Lang | Neuropsychiatry | 2023 |
| MRI, FLAIR | ADNI-4 (Alzheimer's Disease Neuroimaging Initiative -4). ADNI4 is a non-randomized non-treatment natural-history study with a goal of determining the relationships among the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's disease (AD), as the pathology evolves from normal aging through very mild symptoms, to mild cognitive impairment (MCI), to dementia (DEM). ADNI4 continues the previously funded AD Neuroimaging Initiative (ADNI1, ADNI-GO, ADNI-2 and ADNI3), and will continue to inform the neuroscience of AD, identify diagnostic and prognostic markers, identify outcome measures that can be used in clinical trials, and help develop the most effective clinical trial scenarios. | Robin Hsiung | Neurology | 2023 |
| MRI, FLAIR | A Phase 2a, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety and Efficacy of PTC518 in Subjects with Huntington’s Disease. Medicine is available to help with the symptoms of Huntington disease (HD), but currently there is no treatment that can prevent the disease or delay the physical, mental and behavioral symptoms it causes. HD is caused by the presence of a toxic mutant huntingtin (mHTT) protein. There is research evidence to support the idea that lowering mHTT protein should slow the progression of HD. This study is testing the experimental drug called PTC518, whether it can slow the progression of HD by reducing the production of mHTT. | Blair Leavitt | Centre for Huntington Disease | 2023 |
| MRI, FLAIR, QRM, DWI | A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy, Safety, and Tolerability of BIIB080 in Subjects with Mild Cognitive Impairment Due to Alzheimer’s Disease or Mild Alzheimer’s Disease Dementia (CELIA Study). The purpose of the CELIA study is to look at whether BIIB080 (the study drug) can help people with Alzheimer's disease, how safe it is, and how the body handles taking it (known as tolerability). The study will have 3 periods: Screening period (about 9 weeks), Treatment period (76 weeks or approximately 18 months), and Follow-up period (20 weeks or 5 months). Study procedures will include: Administration of the study drug or placebo via lumbar puncture, CSF sampling, questionnaires, cognitive assessments, MRI brain scan, electrocardiogram (ECG), blood and urine collection, neurological exam, physical exam, vital signs, questions about medical history and changes in medication. Website Link: https://card.med.ubc.ca/research/ | Robin Hsiung | Neurology | 2023 |
| MRI, FLAIR, QRM, DWI | A Phase 3b/4 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Verify the Clinical Benefit of Aducanumab (BIIB037) in Participants with Alzheimer’s Disease (Biogen ENVISION study). The Biogen ENVISION study is a double-blind, placebo-controlled, longitudinal study that aims to verify the long-term safety and efficacy of monthly infusions of the investigational drug aducanumab compared with placebo in people with Alzheimer disease (AD). The study includes magnetic resonance imaging (MRI), positron emission tomography (PET, optional), electrocardiography (ECG), blood sampling, cerebral spinal fluid (CSF) sampling (optional), neuropsychological testing, and caregiver interviews to assess the effects and safety profile of aducanumab. Website Link: https://card.med.ubc.ca/research/ | Robin Hsiung | Neurology | 2023 |
| MRI | Integrative imaging of marine mammals: adaptations for feeding and diving in whales and enhanced post mortem examination procedures. The Shadwick lab specializes in functional morphology of cetaceans (whales, dolphins and porpoises) with a particular interest in the aerodigestive pathway. In addition to dissection of gross specimens from stranded and hunter harvested animals, diagnostic imaging (CT and MR) has proved invaluable in advancing the current knowledge of mammalian adaptation to the marine environment. Whole body imaging of seals, sea lions and sea otters is also pursued to develop and better define the application of Lidar for health assessments of free ranging and nutritional condition of dead stranded marine mammals. | Robert Shadwick | Zoology | 2023 |
| MRI, rs-fMRI, tb-fMRI, DTI, QRM | The role of a personalized music intervention towards alleviating apathy in Parkinson’s Disease. Apathy is a common neuropsychiatric disturbance that manifests in approximately a quarter of patients in early stages of Parkinson’s Disease (PD). Music-based interventions have been shown to alleviate apathy in other clinical populations; the mechanisms, however, of how music carries out its anti-apathetic effects, especially in Parkinson’s Disease, are poorly elucidated. This study aims to examine the underlying mechanisms of a receptive music-based intervention (music listening) on alleviating apathy, with a focus on observing functional connectivity between the reward and auditory networks implicated in musical reward processing. | Silke Appel- Cresswell | Neurology | 2023 |
| MRI, DTI, rs-fMRI, QRM | DOD spinal cord study: Eccentric motor training with neuromodulation and biomarkers for rehabilitation readiness in subacute SCI. This study is designed to test certain features called biomarkers in the blood and spinal fluid to help improve treatments for walking and promoting health in people with Spinal Cord Injury. At UBC, we will collect reference brain data (MRI) from healthy control subjects at one time point (one scan) as well and perform analyses on data from patients collected at the Ohio State University. www.brain.rehab.med.ubc.ca | Lara Boyd | Physical Therapy | 2023 |
| MRI | OLERO (Roche/MN43964) study -A Multi-center, Single-arm, Open-label, Extension, Rollover Study to Evaluate the Long-term Safety and Efficacy of Ocrelizumab in Patients with Multiple Sclerosis. Study MN43964 (Olero) is a single-arm, open-label extension (OLE), rollover study of ocrelizumab that allows for participants in Parent studies to continue treatment with ocrelizumab and thereby, aims at the continuation of collecting long-term safety and efficacy data. | Robert Carruthers | MS & NMO Clinical Trials Group | 2023 |
| MRI, FLAIR, rs-fMRI, DTI | “A Placebo-Controlled Efficacy in iNPH Shunting (PENS) Trial” - Adult Hydrocephalus Study. Idiopathic Normal Pressure Hydrocephalus is a condition of over- accumulation of cerebrospinal fluid (CSF) commonly seen in the elderly and of unknown cause, with current treatment paradigms involving surgical interventions such as shunting the CSF from the ventricles in the brain to the peritoneum in the abdomen. The current literature surrounding INPH has been insufficient and there remains a need for a placebo controlled study. The Placebo-Controlled Effectiveness in INPH Shunting (PENS) trial is a multi-centre blinded, randomized, placebo-controlled design investigation of CSF shunt surgery. | Thomas Zwimpfer | Neurosurgery | 2023 |
| MRI, FLAIR, DTI, rs-fMRI, tb-fMRI, Single Echo | Modulating interhemispheric inhibition after stroke. The aim of this work is to identify biomarkers to predict who will respond to interventions involving inhibitory brain stimulation after stroke, and generate new knowledge related to our understanding of the mechanisms of inhibitory brain stimulation. While inhibitory brain stimulation shows promise in promoting recovery after stroke when paired with motor practice, its response is variable: we do not know how stroke-related factors influence its subsequent impact on motor-related brain activity. By employing task-based functional magnetic resonance imaging pre and post stimulation, the current study will examine the impact of inhibitory brain stimulation on motor-related brain activity after stroke. | Lara Boyd | Physical Therapy | 2023 |
| MRI, FLAIR, SWI, DWI | UX701-CL301. A Randomized, Double-blind, Placebo-controlled, Multicenter, Seamless, Adaptive, Safety, Dose-finding, and Phase 3 Clinical Study of UX701 AAV-mediated Gene Transfer for the Treatment of Wilson Disease, Industry (Ultragenyx) | Vladimir Marquez Azalgara | Gastroenterology | 2022 |
| MRI-PDFF | Merck NASH MK-3655-001. A Phase 2b Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-3655 in Individuals with Pre-cirrhotic Nonalcoholic Steatohepatitis | Saumya Jayakumar | Gastroenterology | 2022 |
| MRI, FLAIR, rs-fMRI, DTI, MWI | IMPACT 360 for Healthy Agers. The purpose of this study is to evaluate effects of a multimodal intervention in healthy older adults and elucidate mechanisms driving associated changes. Participants will take part in a 6 month intervention involving exercise, mindfulness, and nutrition. The comprehensive assessment will focus on: cognition, inflammation, microbiome diversity, sleep quality, neurological imaging markers, fitness, cardiovascular health, and well-being. This assessment will: 1) Help us understand the mechanisms behind the benefits of this intervention and any interactive effects and 2) to serve as a normative dataset for replication in clinical populations. | Silke Appel- Cresswell | Neurology | 2022 |
| MRI, FLAIR, rs-fMRI, DWI, MWI, SWI | Canadian Longitudinal Study on Aging (CLSA): Follow-up 3, Healthy Brains and Healthy Aging Initiative. The CLSA Healthy Brains, Healthy Aging Initiative is a six-year study, funded by the Weston Family Foundation, that will create new datasets to enhance the CLSA database and facilitate independent research into the link between lifestyle, the human microbiome, and brain health. The study will involve 6,000 research participants enrolled in the CLSA, including more than 2,500 who will undergo magnetic resonance imaging (MRI) to monitor brain structure and function as they age. The resulting standardized datasets will be available for use by approved public-sector researchers in Canada and internationally. | Teresa Liu-Ambrose | Physical Therapy | 2022 |
| MRI, FLAIR, DWI, QRM, SWI | Colchicine for the Prevention of Vascular Events after an Acute Intracerebral Hemorrhage (CoVasc-ICH) – Optional MRI Sub-study. CoVasc-ICH Optional MRI Sub-Study enrolls interested participants from the main CoVasc-ICH study. This sub-study will try to determine the effects of colchicine on perihematomal edema formation and remote diffusion weighted imaging lesions on MRI. | Thalia Field | Vancouver Stroke Program | 2022 |
| MRI, rs-fMRI, fMRI, MWI, SWI, DTI | Mechanisms of non-invasive brain stimulation as a treatment option for patients with Parkinson's (All-Dressed). In this study, Parkinson’s Disease subjects perform a simple motor task, while they receive subthreshold Electrical Vestibular Stimulation (EVS), and we simultaneously record motor vigour, fMRI and EEG. Different “calibration” stimuli will be delivered in the scanner, and the resultant recordings will be used to train a model to predict vigour from an arbitrary set of stimulation parameters. Precision designed EVS will be later tested outside of the scanner to see if this results in clinically-relevant enhancements in motor task performance. | Martin McKeown | Neurology | 2022 |
| MRI, ASL, DWI, DTI, SWI, MWI | (ACQUIRE) Feasibility of multi-domain data acquisition in patients at risk for hypoxic-ischemic brain injury following cardiac arrest: a cohort study. The ACQUIRE study designed to assess the feasibility data collection in multiple domains (Cerebral Blood Flow using transcranial Doppler, biomarkers of neurologic injury, electroencephalography and neuroimaging). In addition, we are seeking to determine the feasibility of clinical outcome assessment and neuroimaging at 6-months. | Don Griesdale (with Will Panenka) | Dept. of Medicine, Anaesthesiology | 2022 |
| MRI, FLAIR, ASL, rs-fMRI, DTI, SWI | FCD - Memory after Concussion 2.0. This study aims to advance our understanding of why memory problems often persist after concussion, after the brain has seemingly healed. We will be collecting MRI data to confirm that memory complaints after concussion are not directly related to measures of traumatic brain pathology, including corpus callosum white matter integrity and microbleeds. Using resting state fMRI, we will also investigate functional connectivity between the salience network and memory system in the brain in individuals with memory complaints after concussion and those without such complaints to determine whether differences between groups are observable at the level of brain function. | Noah Silverberg | Psychology | 2022 |
| MRI, FLAIR, DTI (MDD), Spectro - single voxel, QRM (MWI) | Prediction of Cognitive and Motor Symptom Progression in Multiple Sclerosis Using Myelin Imaging. A.K.A: Longitudinal Observation of Brain and Spinal cord T2 Relaxation – Brief Interlude Subsequent Quantitative Evaluation (LOBSTR BISQUE). In this study, we will ask our previous volunteers with MS to return 4 years after their original visit so we can collect additional physical, cognitive and myelin MRI data. We will explore whether the amount of myelin at the beginning of the study can predict changes in disability. We will also use new MRI tools to determine what other biological changes, in addition to myelin damage, are linked to progression. Understanding the link between biological changes (in particular myelin) and physical and cognitive changes will allow these more specific imaging methods to be used in clinical trials trying to slow myelin damage and progression. | Shannon Kolind | MS & NMO Clinical Trials Group | 2022 |
| MRI, FLAIR Novel optimized ultrashort echo time multiband hydrogen pulse sequences | Radiofrequency Pulse and Pulse Sequence Design for Accelerated Sodium Magnetic Resonance Imaging. While MRI excels at for detailed images of soft tissue lesions, including those due to traumatic brain injury, it difficult to use MRI to characterize damage to the bone. Ultrashort echo time (UTE) pulse sequences enable the acquisition of signal from tissues with short T2 relaxation time, but they overall scan times tend to be very long due to inefficiencies elsewhere in the sequence. This work aims to develop novel, optimized RF pulse sequences by employing novel MB prepulses. | Rebecca Feldman | Physics & Astronomy | 2022 |
| MRI | A randomized, open-label, parallel-group, 18-month Phase 3 study to evaluate the effect of venglustat compared with usual standard of care on left ventricular mass index in participants with Fabry disease and left ventricular hypertrophy” Sanofi EFC16158 CARAT. | Anna Lehman | Adult metabolic Diseases Clinic | 2022 |
| MRI, 3 PLANE, FLAIR | F. Hoffmann-La Roche - FENTREPID (GN41791) study - - Site 327128. NeuroRx Research. A Phase III Multicenter, Randomized, Double Blind, Double Dummy, Parallel Group Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared with Ocrelizumab in Adult Patients with Primary Progressive Multiple Sclerosis. A study to evaluate the efficacy and safety of fenebrutinib on disability progression in adult participants with Primary Progressive Multiple Sclerosis (PPMS). All eligible participants will be randomly assigned to either daily oral fenebrutinib (or placebo) or intravenous (IV) ocrelizumab (or placebo). | Robert Carruthers | MS & NMO Clinical Trials Group | 2022 |
| MRI, 3 PLANE | A randomized, open label, multi-center, active-comparator study to assess the efficacy, safety and tolerability of ofatumumab 20mg sc monthly versus continued current therapy in relapsing-remitting multiple sclerosis after elevation of serum neurofilament light levels (SOSTOS). Novartis This study will evaluate if relapsing-remitting MS patients that have not had a relapse in the past year would benefit from a switch to ofatumumab versus staying on their continued current therapy. This study will also look at whether an elevated serum neurofilament light (NfL) level predicts enhanced benefit from a switch to ofatumumab. | Alice Schabas | MS & NMO Clinical Trials Group | 2022 |
| MRI, DTI, ihMT | Advanced MRI techniques to measure spinal cord microstructure in vivo: development and reproducibility. This study involves testing advanced MRI techniques (myelin water imaging, inhomogeneous magnetization transfer and diffusion imaging) to measure changes in the spinal cord after spinal cord injury. In this first stage we will optimize these techniques for spinal cord scanning on our 3T scanner and determine reproducibility for white and grey matter regions of interest. | Corree Laule | ICORD/ MRI Research Centre | 2022 |
| MRI | A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study with Open-Label Extension to Evaluate the Safety. Tolerability, Pharmacokinetics and Pharmacodynamics of LMI070/branaplam when Administered as Weekly Oral Doses in Participants with Early Manifest Huntington's Disease. | Blair Leavitt | Centre for Huntington Disease | 2022 |
| MRI, DWI, FLAIR, | A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, 76-Week Study Evaluating the Safety and Efficacy of Two Doses of Simufilam in Subjects with Mild-to Moderate Alzheimer’s Disease. This study will investigate the safety and effectiveness of simufilam with those in placebo, in participants who are diagnosed with mild to moderate Alzheimer disease. Simufilam is an oral drug meant to restore the normal shape and function of a brain protein called filamin A (FLNA). In patients with Alzheimer disease, the shape of FLNA is distorted. This triggers toxic signaling beta amyloid, and ultimately results in brain cell degeneration and inflammation. | Robin Hsiung | Neurology | 2022 |
| MRI, DWI, DTI, FLAIR, rs-fMRI, ASL | Roche WN42444 study: A Phase III, Multicenter, Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of Gantenerumab In Participants At Risk For Or At The Earliest Stages Of Alzheimer’s Disease. People who have elevated brain amyloid levels may be at risk for or at the earliest stages of Alzheimer’s disease because they have signs of one of two core pathologies of Alzheimer’s disease (abeta amyloid or herein simply “amyloid”), although they do not have symptoms. The purpose of Study WN42444 is to compare the effects, good or bad, of gantenerumab with those of placebo in participants who are cognitively unimpaired and have elevated levels of amyloid protein in the brain. Gantenerumab is a man-made antibody that attaches to amyloid in the brain and mobilizes the immune system to remove it. | Robin Hsiung | Neurology | 2022 |
| MRI, tb-fMRI | Transfer of Valence - fMRI equipment testing. Prior work suggests that emotion not only alters memory for emotional content per se but can also alter memory for and attitudes towards associated experiences, a process known as transfer of valence. The neural correlates of these effects, however, have yet to be thoroughly investigated. To help us gain a better understanding of how emotion affects transfer of valence, we will ask participants to study pairs of images: one object (always neutral) and one scene (negative or neutral). We will then have participants complete a test phase where they will rate the pleasantness of the neutral objects followed by a memory task to determine memory for the pairings in each condition (negative vs. neutral). | Daniela Palombo | Psychology | 2022 |
| 3-point Dixon; Proton spectroscopy | Sexual dimorphism in physiological and bioenergetic responses to aerobic exercise. Physical activity is a necessity for healthy living and dependent on the delivery of oxygen to the working muscles to generate energy. Our understanding of the body’s response to physical activity has primarily been characterized using the “typical 70-kg man”, yet substantial sex-differences in the lungs, heart, blood vessels, blood, and muscle may lead men and women to use different mechanisms to deliver oxygen and produce energy during activity. Our study will investigate these differences with a focus on various muscle characteristics including quantity, structure, fibre type, and respiratory capacity. | Robert Boushel | Kinesiology/ Fac. Of Education | 2022 |
| MRI, DTI, rs-fMRI | Left intermittent Theta Burst Stimulation vs. Right Low Frequency Repetitive Transcranial Magnetic Stimulation Effectiveness in Depression and Suicidal Ideation: A Randomized Non-Inferiority Trial (Left vs. Right Non-Inferiority Trial - LeRNIT). MDD poses a great economic burden on the health care system due to its long-term disability with a low ability to participate in everyday activities. We aim to understand the mechanism of action of rTMS in clinical practice, improve the targeting of this treatment avenue using functional MRI scans, and investigate novel markers, such as heart rate variability, as an indication of treatment response. https://ninet.med.ubc.ca/research/ | Fidel Vila-Rodriguez | Psychiatry | 2021 |
| MRI, MWF, FLAIR | VISIONARY-MS: A Phase 2, Randomized, Double-Blind, Parallel Group, Placebo Controlled Study for the Treatment of Visual Pathway Deficits In Chronic Optic Neuropathy to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of CNM-Au8 For Remyelination In Stable Relapsing Multiple Sclerosis (RMS). CLENE Nanomedicine, SNAC-Sydney Neuroimaging Analysis Centre. | Tony Traboulsee | MS & NMO Clinical Trials Group | 2021 |
| MRI, DWI, STIR | Evaluation the role of transcervical 3D Ultrasound imaging of the oropharynx during transoral robotic surgery - TORS. Transoral robotic surgery has the potential to provide better surgery outcome to patients with early-stage oropharyngeal SCC, and advances in image guidance during this procedure can optimize resection margins, as well as reduce the risk of complications such as neurovascular injury. The objective of our study is to assess the utility of using 3D transcervical ultrasound to assess oropharyngeal anatomy and pathology and the feasibility of ultrasound-MRI registration for intraoperative image guidance. | Eitan Prisman & Tim Salcudean | Surgery + Electrical & Computer Engineering | 2021 |
| MRI, rs-fMRI, tb-fMRI | Functional role of eye movements during motor sequence learning (Short title: Sensorimotor imaging & learning [SMiLE]). The sensorimotor imaging & learning (SMiLE) study will evaluate how oculomotor control contributes to implicit motor sequence learning in healthy, young and older adults. Participants will practice a novel skilled reaching task for 3 days and undergo structural and functional magnetic resonance imaging before and after training. We will investigate change in brain connectivity associated with motor sequence learning. Our findings will contribute to better understanding of the underlying mechanisms contributing to skill learning in healthy adults. | Lara Boyd | Physical Therapy | 2021 |
| MRI, rs-fMRI | Technical development time to test new MR-Rapid open bird-cage MR coil for concurrent TMS-MRI applications in phantoms | Fidel Vila-Rodriguez | Psychiatry | 2021 |
| MRI, DWI, FLAIR | LIBERTO- Single arm, open label multicenter extension study to evaluate the effectiveness and safety of Ocrelizumab in patients with multiple sclerosis previously enrolled in a F. Hoffmann-La Roche sponsored Ocrelizumab phase IIIb/IV clinical trial. | Robert Carruthers | MS & NMO Clinical Trials Group | 2021 |
| MRI, tb-fMRI | Emotional Localization. We want to investigate how emotional distractions around us can influence how we see and interact with other non-emotional objects arounds us. Specifically, we want to understand information presented to different senses (e.g., vision, audition) impacts our spatial awareness of the environment. We will utilize specialized behavioral tasks and powerful MRI scanners to help us uncover the underlying patterns of brain activity that guides our attention and action when we are emotionally stimulated. | Rebecca Todd | Psychology | 2021 |
| MRI, rs-fMRI, fMRI | Adapt and Avoid – fMRI. Altered patterns of avoidance behaviours – which entail taking or withholding action to prevent unpleasant outcomes – are a feature of anxiety and depression; however, we only have a limited understanding of the neural circuits that underpin these behaviours. To address this gap in the literature, we adapt an rodent-based investigation of the neural correlates of avoidance behaviours into a human context (in which participants must learn which stimuli are associated with the need to make or withhold a series of button presses in order to avoid an unpleasant outcome). In particular, we focus on the neural representations of stimuli that signal the appropriate avoidance response to be made and the aversive or neutral outcome of the response to these stimuli. | Rebecca Todd | Psychology | 2021 |
| MRI, rs-fMRI, tb-fMRI | Cannabis and Polysubstance Use: Imaging Response Inhibition and Stress Exposure (CAPU RISE). Most stimulant users also use cannabis. The majority of cannabis users report stress reduction and coping motives for their use; however, there remains little biological evidence of cannabis reducing acute stress. This randomized control clinical drug trial employs a range of methods including biosampling, self-reports, actigraphy, and neuroimaging to examine the effects of cannabinoids on stress response, inhibition, and sleep in cannabis and stimulant co-users. | Christian Schütz | Psychiatry | 2021 |
| MRE, MRI-PDFF | The Sonic Incytes Liver Incyte System, evaluation of liver fibrosis and steatosis versus MRE and MRI PDFF. SI-CLIN-02. This study aims to evaluate the correlation of liver elasticity measurements between an investigational ultrasound-based measurement device (Liver Incyte System, manufactured by Sonic Incytes), the standard of care (FibroScan) as well as the non-invasive gold standard (MRE). In addition, this project aims to evaluate the discriminatory ability and investigate cut-offs for different stages of liver disease progression of the Liver Incytes System. | Alnoor Ramji | Gastroenterology, GI Research Institute | 2021 |
| MRE, MRI-PDFF | A Phase 2b Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (Merck NASH). | Alnoor Ramji | Gastroenterology, GI Research Institute | 2021 |
| MRI, rs-fMRI, fMRI | Individualized pathways to recovery after stroke. Pairing brain stimulation with rehabilitation after stroke is a promising approach. However, early studies of this intervention responses proved to be highly variable. Some people showed a strong benefit while others did not. The main aim of the proposed program of research is to identify biomarkers that can be used to predict response to brain stimulation interventions. www.brain.rehab.med.ubc.ca | Lara Boyd | Physical Therapy | 2021 |
| MRI, MRS, | MRS in healthy participants: Neurochemical Atlas. This study involves creating a metabolic map of the cingulate gyrus using optimized MRS parameters (sLASER, TR/TE=5000/32ms). We will examine the link between each voxel’s glutamate concentration and pain sensitivity (i.e., pain thresholds and laser evoked potentials). Further, the spatial distribution and variability of all metabolic concentrations will be examined. | John Kramer, Erin MacMillan | ICORD | 2021 |
| MRI, rs-fMRI | Technical proposal for testing real-time motion detection/ correction patch | Fidel Vila-Rodriguez, Erin MacMillan | Non-Invasive Neurostimulation Therapies Lab (NINET) / MRI Research Centre | 2021 |
| MRI, rs-fMFI, DTI, QRM (MWI) | A prospective and longitudinal investigation of concussive and subconcussive mild traumatic brain injury mechanisms in ice hockey. This study aims to address the public health problem of concussions and subconcussive head impacts in contact sports such as ice hockey. Our investigation will examine the mechanisms of (sub)concussions on brain function changes with mechanical trauma occurred over multiple hockey seasons. Findings from the study will inform how accumulation of trauma leads to long-term health problems including depression and severe personality change. | Alex Rauscher, Lyndia Wu | MRI Research Centre, Mechanical Engineering | 2021 |
| MRI, DWI, SWI, MWI, rs-fMRI | Canadian Longitudinal Study on Aging: Coronavirus Disease 2019 (CLSA: COVID) Study. Canadian Longitudinal Study on Aging COVID-19 Study: This study will compare brain structure, connectivity, and risk of silent stroke in older persons who have a history or symptoms of COVID-19 compared to older people without a history or symptoms of COVID-19. | Teresa Liu-Ambrose | Physical Therapy, Canada Research Chair in Physical Activity, Mobility, and Cognitive Health | 2021 |
| MRI, DWI, ASL | "ANAVEX2- 73", A Phase 2b/3, Double-Blind, Randomized, Placebo-Controlled 48-week Safety and Efficacy trial of ANAVEX2-73 for the Treatment of Early Alzheimer’s Disease (AD). This study will investigate the safety and effectiveness of ANAVEX2-73 in people diagnosed with early to mild Alzheimer disease. Participants will be randomised to receive either high or low dose ANAVEX2-73 or placebo (33% chance) over a period of 48 weeks. The study drug may protect brain neurons (brain nerve cells) that are usually damaged in Alzheimer’s disease, which may enable ANAVEX2-73 to modify AD. After the screening and baseline visit, participants will return to the Clinic every 3 months for assessments that include cognitive testing, sleep questionnaires, study partner interviews, occasional safety labs, urinalysis and ECG. Outcome measures include regular assessments of cognitive and functional abilities. | Robin Hsiung | Neurology | 2021 |
| MRI, DWI, QRMs | "EMBARK", Phase 3b Open-Label, Multicenter, Safety Study of BIIB037(aducanumab) in Subjects with Alzheimer’s disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205. The Biogen EMBARK study is an open-label, longitudinal study of the investigational drug aducanumab. The aim of the study is to assess the long-term safety and efficacy of monthly infusions of aducanumab in patients with Alzheimer disease. The study includes magnetic resonance imaging (MRI), positron emission tomography (PET), electrocardiography (ECG), blood sampling, cerebral spinal fluid (CSF) sampling (optional), neuropsychological testing, and caregiver interviews to assess the effects and safety profile of aducanumab. | Robin Hsiung | Neurology | 2020 |
| MRI, DTI, SWI, ASL, Perfusion | TRIC-VSI. Trial of Remote Ischemic Conditioning in Vascular Cognitive Impairment. People with mild vascular cognitive impairment are prone to having little strokes, which can cause changes in cognition over time. Currently there are no treatments for mild vascular cognitive impairment that are approved by Health Canada. This study investigates whether Remote Ischemic Conditioning (cutting off blood flow to a limb temporarily without causing tissue damage) can be implemented successfully by patients, and whether it will improve cognition, brain imaging and blood markers. | Thalia Field | Neurology | 2020 |
| MRI, rs-fMRI, tb-fMRI | Modulating interhemispheric inhibition after stroke. The aim of this work is to identify biomarkers to predict who will respond to interventions involving inhibitory brain stimulation after stroke, and generate new knowledge related to our understanding of the mechanisms of inhibitory brain stimulation. While inhibitory brain stimulation shows promise in promoting recovery after stroke when paired with motor practice, its response is variable: we do not know how stroke-related factors influence its subsequent impact on motor-related brain activity. By employing task-based functional magnetic resonance imaging pre and post stimulation, the current study will examine the impact of inhibitory brain stimulation on motor-related brain activity after stroke. | Lara Boyd / Sarah Kraeutner | Physical Therapy | 2020 |
| MRS | MRS Multisite B0 Drift Phantom Study. Contribution of phantom MRS data to a multisite B0 drift study lead by researchers at Johns Hopkins University. | Erin MacMillan | MRI Research Centre | 2020 |
| MRI, DWI, QRM, MT | Natural History of Mild Degenerative Cervical Myelopathy: an observational study. This study will permit identification of the key clinical, radiological and serum biomarker related variables predicting clinical deterioration of degenerative cervical myelopathy (DCM) patients. Such knowledge will facilitate improvements in the treatment of DCM, allowing surgeons to provide personalized recommendations depending on expected clinical course. | Nicolas Dea | ICORD, Neurosurgery | 2020 |
| MRI, SWI | CANARY- Clinical dAta, Natural language pRocessing and eYe tracking for dementia risk stratification. Our study is attempting to explore the relationship that exists between eye movement patterns, speech patterns, and cognitive decline. This study compares the speech and eye-movements of people with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) to healthy volunteers, to see if there are patterns that can be used to detect Alzheimer’s disease early, and to monitor the progression of Alzheimer’s disease over time. Link to our study: https://www.vchri.ca/research-study/clinical-data-and-natural-language-processing-early-detection-dementia-canary | Thalia Field | Neurology | 2020 |
| MRI, rs-fMRI | Burnout and Resilience among Medical Professionals during COVID-19. Burnout in the medical field has long been recognized as a significant problem. Currently available strategies to reduce burnout and build resilience against it are of limited effectiveness and are highly variable in their outcomes. This research will inform the selection and further development of more effective strategies, by using functional magnetic resonance imaging (fMRI) to provide a strong neuroscientific basis for the selection process. UBC Cognitive Neuroscience of Thought Laboratory: http://www.christofflab.ca/ | Kalina Christoff | Centre for Brain Health | 2020 |
| MRE | A Phase 2, randomized, double-blind, placebo-controlled, multicenter, multinational, dose-finding study to evaluate the efficacy and safety of CC-90001 compared with placebo, in subjects with non-alcoholic steatohepatitis (NASH) and Stage 3 or Stage 4 liver fibrosis. | Eric Yoshida | Gastroenterology | 2020 |
| rs-fMRI, Perfusion, MRI | ALLFTD: ARTFL-LEFFTDS Longitudinal Fronto-temporal Lobar Degeneration. The study aims to evaluate sporadic (s-) and familial (f-) frontotemporal lobar degeneration (FTLD) patients and asymptomatic family members of f-FTLD patients, characterizing the cohorts longitudinally and informing clinical trial design. The study has two arms: a “longitudinal arm” involving a comprehensive assessment of clinical, functional, imaging, and biofluid data collection, and a “biofluid-focused arm” involving limited clinical data to accompany biospecimen collection. | Ian Mackenzie | Pathology & Laboratory Medicine | 2020 |
| DWI, FLAIR, SWI | CATIS-ICAD, Combination Antithrombotic Treatment for prevention of recurrent Ischemic Stroke in IntraCranial Atherosclerotic Disease: Protocol for a Pilot randomized trial. | Samuel Yip | Vancouver Stroke Program | 2020 |
| MRI | FH Achilles Tendon Longitudinal (FHATL) Study. Our study aims to enhance our understanding of the impact of Familial Hypdercholesterolemia on tendon health; a highly under-researched area of significant clinical importance. With the use of non-invasive techniques, we aim to examine various determinants of tendon functional recovery in individuals with newly diagnosed Familial Hypdercholesterolemia. This information is fundamental in identifying if current Familial Hypdercholesterolemia treatments methods reverse the functional and structural effect of the lipid accumulation within the tendon. | Alexander Scott | Centre for Hip Health & Mobility | 2020 |
| MRI, fMRI , BOLD, | Neural Recruitment During Spontaneous Thoughts. People frequently experience thoughts which seem to ‘come out of nowhere’, however, the neural underpinnings of this common psychological happening are poorly understood. Using fMRI scanning, we will investigate neural activity in human brains before a thought reaches one’s awareness, once it reaches awareness, during its subsequent elaboration (as a stream of thought), and during its dissipation. Find out more about this research on our laboratory website: http://www.christofflab.ca/ | Kalina Christoff | Psychology | 2020 |
| MRI, SWI, FLAIR | Myelin Water Imaging in NMDA Receptor Autoimmune Encephalitis – Pilot Study. Autoimmune encephalitis (AIE) is a serious condition caused by misdirected immune response against the brain. Magnetic Resonance Imaging (MRI) is used for the detection of brain abnormalities in many neurological conditions but routine MRI studies are normal in the majority of AIE cases, despite the obvious widespread neurological dysfunction. We aim to determine if there is damage to myelin due to widespread inflammation using Myelin Water Imaging (MWI) in AIE patients and if these relate to abnormalities in cognitive testing, serum neurofilament light-chain levels (a blood biomarker of neuronal damage), and retinal measurements obtained by optical coherence tomography. | Tony Traboulsee | MS & NMO Clinical Trials Group | 2020 |
| MRI, fMRI, DTI | CAN-BIND Validation study- Intergrated Biological Markers for the Prediction of Treatment Response in Depression. The purpose of our study is to learn about ‘biomarkers’ (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression. This study involves standard treatment for depression. Patients will be treated by a psychiatrist for 16 weeks with an antidepressant medication approved to treat depression. No placebos are being used. | Raymond Lam | Psychiatry | 2020 |
| MRI | SEARCH - StrokE and vAscular Risk factors contributing to neuroCognitive decline in adult & children congenital Heart disease. Adults with Congenital Heart Disease (CHD) are at increased risk of clinical and silent infarcts as well as dementia. The SEARCH study will be the first prospective cohort study in CHD patients evaluating silent cerebrovascular disease over time, and how this is associated with cognitive changes and other vascular risk factors. We will evaluate children and adults with CHD in BC over 3 years using neuroimaging, cognitive testing, and other imaging and bloodwork to try to address these knowledge gaps. https://www.vancouverstrokeprogram.com/research/search-study/ | Thalia Field | Neurology | 2020 |
| MRI-PDFF, MRE | A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (resmetirom) in Patients With Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation- Madrigal MG-3196-11. | Eric Yoshida | Gastroenterology | 2019 |
| MRI, MRI-PDFF | The Sonic Incytes Liver Incyte System, assessment of liver fibrosis and steatosis, SI-CLIN-01. This study looks to compare the use and results of a new ultrasound based measurement device (Liver Incyte, manufactured by Sonic Incytes) to the standard of care (FibroScan) as well as the non-invasive gold standard (MRE). In addition we would like to compare the fat measurement ability of ultrasound attenuation coefficient compared to that of MRI-PDFF. | Eric Yoshida | Gastroenterology | 2019 |
| MRI | Long-term extension safety and efficacy study of SAR442168 in participants with relapsing Multiple Sclerosis | Tony Traboulsee | MS & NMO Clinical Trials Group | 2019 |
| MRI | The Longitudinal Course of Intracortical Myelination and Cognitive Function in Bipolar Disorder | Lakshmi Yatham | Psychiatry | 2019 |
| MRI, rs-fMRI, MRSI | Offsetting hippocampal degeneration in moderate to severe TBI. This randomized control trial is assessing the feasibility and efficacy of an online 16-week intervention employing allocentric spatial navigation tasks to enhance learning and memory capacity and to improve structure and function of the hippocampus following a moderate-severe traumatic brain injury (m-sTBI). Participants will undergo an MR scan, blood collection, and an assessment of behavioural outcomes 7 months and 12 months following a m-sTBI. Participants in the treatment arm complete the online intervention between these time-points while the controls do not. | William Panenka | Psychiatry | 2019 |
| MRI, tb-fMRI, MWF | Cortical Responses to Visual Triggers in Urgency Urinary Incontinence Demonstrated Through Functional Magnetic Resonance Imaging. | Lynn Stothers | ICORD | 2019 |
| rs-fMRI | Regional brain activation during different forms of response inhibition, comparing young healthy adults with individuals with Bipolar Disorder. People living with bipolar disorder often have problems with controlling impulsivity. Using MRI, we will identify subcomponents of response inhibition, a specific form of impulsivity. After, participants will receive 3 rounds of Transcranial Magnetic Stimulation (TMS) to test whether or not we can use it to change impulsivity. | Christian Schütz | Psychiatry | 2019 |
| MRI, rs-fMRI | The GBA multimodal study | Jon Stoessl | Neurology, Pacific Parkinson Research Centre | 2019 |
| MRI, MEDIC | Hemorrhage within the spinal cord after acute traumatic injury - the relationship to hemodynamic management and thromboembolic prophylaxis. | Brian Kwon | Orthopaedics, ICORD | 2019 |
| MRI | Linking biomechanical and imaging outcomes to better understand the effects of running on knee joint health. Running is a very popular activity for many adults. However, a diagnosis of knee osteoarthritis is often seen as a “death sentence” for someone’s recreational running career. This study will provide the first evidence to determine the safety of runners for people with degenerative cartilage due to osteoarthritis. https://mablab.rehab.med.ubc.ca/currentstudies/ | Michael Hunt | Physical Therapy | 2019 |
| MRI, DWI | AXIOMATIC - A Global, Phase 2, Randomized, Double-Blind, Placebo- Controlled, Response-Adaptive Dose-Ranging Study of BMS-986177, an Oral Factor XIa Inhibitor, for the Prevention of New Ischemic Stroke or New Covert Brain Infarction in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA) | Philip Teal/ Thalia Field | Neurology | 2019 |
| MRI, rs-fMRI, DTI, GRASE | Does Opera training sculpt the brain to learn? Study 1- Language Intensive. Learning how to perform opera is both cognitively and physically demanding, yet some of the students who have been most successful in UBC’s Opera Program have had learning-related disabilities, and appear to have overcome their difficulties, or to have learned compensatory skills that help them not just in opera performance but beyond. The goal of the proposed research is to systematically evaluate and better explain the neural foundations of that observation. In this endeavor, a study is proposed to measure executive function and other learning capabilities before and after a month-long language intensive course that is a required component of UBC opera training, and to determine – through MRI measurement of anatomical changes in fiber tracts in the brain – the neural bases of any observed behavioral improvements. | Lara Boyd | Physical Therapy | 2019 |
| MRI, DWI, SWI | CanProCo – Canadian Proactive Cohort Study for People Living with Multiple Sclerosis. Canadian Proactive Cohort Study for People Living with Multiple Sclerosis (CanProCo) is an observational study designed to better understand the factors that contribute to MS disease progression using tools from different fields such as epidemiology (i.e. number of patients and distribution of diseases), medical imaging, and immunology (blood). Subjects will participate in annual visits over a 5-year period. | Tony Traboulsee | MS & NMO Clinical Trials Group | 2019 |
| MRI | A Phase 2B Dose-finding study for SAR442168, A Bruton's tyrosine kinase inhibitor, in participants with relapsing Multiple Sclerosis (Sanofi DRI15928) | Tony Traboulsee | MS & NMO Clinical Trials Group | 2019 |
| MRI | An open-label, single-arm 4-year study to evaluate effectiveness and safety of Ocrelizumab treatment in patients with Progressive multiple sclerosis. (Roche Consonance- MN39159) | Robert Carruthers | MS & NMO Clinical Trials Group | 2019 |
| MRI, MWI | [Roche] Pilot study of PET (Positron Emission Tomography) Imaging: Correlations with Advanced MRI in MS | Robert Carruthers | MS & NMO Clinical Trials Group | 2019 |
| MRI | HOPE- Hip Osteoarthritis Progression Evaluation . Population-Based Longitudinal Cohort Study of Femoroacetabular Impingement of the Hip Using Magnetic Resonance Imaging Outcomes. The goals of the study are to investigate whether radiographic FAI and physical activity are risk factors for progression of cartilage damage and other MRI outcomes over 7 years. This study includes a randomly selected population of young adults aged 20-49 with and without hip pain. | Jolanda Cibere | Rheumatology | 2019 |
| MRI, DWI | AbbVie. A Phase 2 Multiple Dose, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABBV-8E12 in Subjects with Early Alzheimer´s Disease. This is a 96-week Phase 2 clinical trial for people with mild cognitive impairment to mild Alzheimer disease. The study treatment, an anti-Tau agent, may be able to block soluble tau aggregates, and thereby decrease the spreading of tau pathology in brains with tauopathy. Patients who meet all of the inclusion criteria will receive monthly IV study treatment or placebo for the duration of their enrollment. | Ging-Yuek Robin Hsiung | Neurology | 2018 |
| MRI, DTI, rs-fMRI | Multi-Site, Prospective, Longitudinal, Cohort Study Measuring Cerebrospinal Fluid Mutant Huntington Protein in Patients with Huntington’s Disease. | Blair Leavitt | Medical Genetics; Centre for Huntington Disease | 2018 |
| fMRI | A randomized, double-blinded, sham-controlled cross-over with open-label extension study of theta-burst stimulation transcranial magnetic stimulation in non-fluent/agrammatic variant primary progressive aphasia. | Fidel Vila-Rodriguez | Psychiatry | 2018 |
| MRI, DWI, Elastography | Optimizing the management of high-risk and unfavorable intermediate-risk disease: the use of advanced imaging, trans-perineal mapping biopsies, and dual-strength brachytherapy sources to minimize radiation dose to normal tissues [OPTiMAL] | Michael Peacock | BC Cancer Agency | 2018 |
| MRI | PET Studies of dopamine turnover and release in bipolar disorder: Montreal Imaging Stress task PET study | Lakshmi Yatham | Psychiatry | 2018 |
| MRI, MTR | MAGNIFY: A 2-year Prospective Study to Evaluate the Onset of Action of Mavenclad® in Subjects with Highly Active Relapsing Multiple Sclerosis | Robert Carruthers | MS & NMO Clinical Trials Group | 2018 |
| TMS-fMRI | TMS-fMRI - Treatment response in TRD with interleaved TMS-fMRI | Fidel Vila-Rodriguez | Psychiatry | 2018 |
| MRI, MWI | Technical development on the Ingenia Elition: MWI, QSM and FLAIR2 | Shannon Kolind, Alex Rauscher, Adam Dvorak | MRI | 2018 |
| MRI; SWI; rs-fMRI | HELP_MS; LEMCOG Healthy Controls - A prospective 24-month investigator sponsored trial to determine the course of cognitive function and how it relates to MRI measures of structural and functional connectivity in healthy controls across time. Collection of non-Multiple Sclerosis (MS) untreated control data is invaluable for interpretation of data acquired in MS treatment trials on cognitive outcomes such as memory. Advanced MRI techniques detect differences in the brain between people with and without MS. Understanding differences in brain connection patterns in people without MS helps us to understand the biological changes that may lead to cognitive challenges in MS. | Shannon Kolind | Neurology | 2018 |
| MRI; SWI | SMOOTH OPERATOR: Smooth Pursuit as a predictor of cerebral small vessel disease. Cerebral small vessel disease (cSVD) is one of the most prevalent neurological disorders and can lead to problems such as dementia or stroke. However, cSVD is usually only discovered on neuroimaging after symptoms develop. We hope to explore the utility of basic bedside assessments (smooth pursuit eye movements and spontaneous speech patterns) as indicators of the presence and severity of underlying cSVD in pre-symptomatic patients. | Thalia Field | Neurology | 2018 |
| MRI; fMRI | ADNI 3: Alzheimer's Disease neuroimaging initiative 3 | Ging-Yuek Robin Hsiung | Neurology | 2018 |
| MRI, fMRI, DWI | SIGNAL: A Phase 2, multi-center, randomized, double-blind, placebo controlled study in subjects with late prodromal and early manifest Huntington’s disease (HD) to assess the safety, tolerability, pharmacokinetics, and efficacy of VX15/2503. | Lynn Raymond | Centre for Huntington Disease | 2018 |
| MRI, fMRI, DWI | Aerobic exercise and CogniTIVe functioning in women with breAsT cancer: the ACTIVATE trial. This study examines the impact of an aerobic exercise intervention on chemotherapy-related cognitive changes (CRCC) in women diagnosed with breast cancer who undergo chemotherapy treatment. The results of this study aim to address the effect and timing of aerobic exercise on CRCC, as well as the outcome of exercise during or following treatment on global measures of brain structure, functioning, and organization through fMRI and EEG assessments. | Kristin Campbell | Physical Therapy | 2018 |
| MRI, DTI, SWI | Mapping the medial forebrain bundle in chronic post-concussive syndrome. We propose that injury to the medial forebrain bundle is the cause of the chronic post-concussive syndrome (PCS). This is a proof of concept study involving a single subject with PCS following a rotational head injury. | Trevor Hurwitz with Josue Avecillas- Chasin | Psychiatry | 2018 |
| MRI, rs-fMRI, DTI, SWI, DBSI, spectrosc. | Susac Syndrome Advanced Characterization (SuSAC): A Multidisciplinary Assessment of the Disease including Advanced MRI, Ocular Coherence Tomography, and Neuropsychological Testing. Susac Syndrome, a rare autoimmune disease often misdiagnosed as Multiple Sclerosis, and is a poorly understood disease with no proven treatments. This study will be the first to combine a multidisciplinary evaluation of clinical status and disease activity with advanced imaging metrics. The results will provide pilot data that may broaden our understanding of disease pathogenesis and allow important structural and functional relationships to emerge. | Robert Carruthers | MS & NMO Clinical Trials Group | 2018 |
| MRI, rs-fMRI, DTI | FOXY- Phase 2 Clinical Trial of Intranasal Oxytocin for Frontotemporal Dementia - MRI Research Centre. The purpose of this study is to evaluate the efficacy of intranasal oxytocin in reducing social apathy in participants with a diagnosis of Fronto-temporal dementia. | Robin Hsiung | Neurology | 2018 |
| MRI, Perfusion, Diffusion | When are blood vessels “ready to rupture”? Cerebrovascular health following spinal cord injury. This study explores the cerebrovascular consequences of intermediate (i.e., 1-2 years) and chronic (i.e., >5 years) exposure to daily autonomic dysreflexia in humans with spinal cord injury. We are interested in finding out if the episodic hypertension associated with autonomic dysreflexia impacts cerebrovascular regulation, which plays a role in predisposing this population to cerebral small vessel disease, overt stroke and cognitive decline. | Dr. Andrei Krassioukov | ICORD | 2017 |
| fMRI | Scene construction in spontaneous thought. This study will look at the neural basis of the thought dynamics and contents; specifically, the difference between freely moving and deliberately constrained thought, both with and without imagery of spatially anchored scenes. To investigate this, we will combine fMRI and experience sampling. | Dr. Kalina Christoff (w/ Yvette Graveline) | Psychology | 2017 |
| MRI, rs-fMRI | Next steps for understanding the neuro-cognitive basis of physical activity adherence. The current study will examine whether individual differences in neural activation using two fMRI experiments predicts future adherence to physical activity over a 6-month period among adults. The first experiment will examine neural responses to the engagement in inhibitory control. The second experiment will examine neural responses to observing health promotion messages related to physical activity and sedentary behavior. | Teresa Liu-Ambrose | Physical Therapy | 2017 |
| rs-fMRI; MRI; DTI; SWI | Novel Retinal Biomarkers for Alzheimer's Disease. Detecting the beginning of Alzheimer disease (AD) in the eye by using a noninvasive imaging device that can show amyloid in the retina. This study is an observational, non-treatment study to identify retinal biomarkers associated with AD, and the outcomes measures include 3T MRI, PiB-PET, 3D/2D Retinal Images, Retinal functional tests, and a variety of cognitive and behavioural interviews. The study will assess the efficacy of the device in rodent models and patients with AD, and if successful, the device may lead to better and earlier diagnosis of AD with lower cost. | Robin Hsiung / Prof. Mirza Faisal Beg (SFU) | Neurology | 2017 |
| MRI | ENSEMBLE: An Open-Label, Single-Arm Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Patients with Early Stage Relapsing Remitting Multiple Sclerosis | Robert Carruthers | MS & NMO Clinical Trials Group | 2017 |
| MRI; rs-fMRI | An Open-Label Extension Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ISIS 443139 in Huntington’s Disease Patients Who Participated in Prior Investigational Studies of ISIS 443139. ISIS 443139-CS2. | Blair Leavitt | Medical Genetics; Centre for Huntington Disease | 2017 |
| MRI; rs-fMRI | Reshaping the Path of Mild Cognitive Impairment by Refining Exercise Prescription. In this proposed study, we will study the effects of different types and combinations of exercise training on cognitive function in older adults who are at increased risk for dementia (i.e., mild cognitive impairment). Older adults with mild cognitive impairment represent an ideal target population for intervention strategies, as the preservation of their cognitive function will likely maintain and prolong their ability to live independently and with quality. Furthermore, we will explore how each exercise type improves cognitive function as such information may lead to new discoveries and therapies. | Teresa Liu-Ambrose | Physical Therapy | 2017 |
| fMRI | Thought Dynamics (Spontaneous Thought). This study will look at the neural basis of the dynamics of thought; particularly, the differences between freely-moving thought and constrained thought. To investigate this, we will combine experience sampling with fMRI. | Kalina Christoff | Psychology | 2017 |
| MRI | Synchronizing Exercises, Remedies in Gait and Cognition (SYNERGIC) Trial. A Randomized Controlled Double Blind Trial. Physical exercises, cognitive training, and vitamin D are low cost interventions and have the potential to enhance cognitive and mobility function in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI). Currently, it is unclear whether aerobic, resistance, or tone and stretching exercise would have different effects on cognitive performance. We postulate that combined strength and aerobic training will have a better effect on cognition over tone stretching-control exercise in an MCI population. Additionally, we will assess if a multi-domain intervention including cognitive training and vitamin D will have synergistic efficacy. | Teresa Liu-Ambrose | Physical Therapy | 2017 |
| MRI | Prostate evaluation for clinically important: MRI vs. standard evaluation procedures (PRECISE). | Peter Black (Silvia Chang) | Prostate Centre | 2017 |
| MRI | Development of Magnetic Resonance Elastography System for Liver Imaging | Tim Salcudean | Electrical and Computer Engineering | 2017 |
| MRI | Testing Inhomogeneous Magnetization Transfer (TIHMT). Inhomogeneous Magnetization Transfer (ihMT) is a new imaging technique that shows promise for myelin selectivity, which could lead to better detection and treatment of demyelinating diseases such as Multiple Sclerosis. This study will compare ihMT to myelin water fraction images, and assess the two techniques’ selectivity to myelin. | Alex MacKay | Physics & Astronomy | 2017 |
| MRS | Implementing GABA editing MRS capacity at UBC | Fidel Vila-Rodriguez | Psychiatry | 2017 |
| MRI, MRS | MEDDAY- effect of MD1003 in progressive Multiple Sclerosis: A randomized double blind placebo controlled study | Virginia Devonshire | Neurology | 2017 |
| MRI; rs-fMRI | LEM-COG: A Prospective 24-Month Observational Study to Evaluate Neurocognitive Function and Safety in Patients with Relapsing Multiple Sclerosis Who Are Initiating LEMTRADA® Treatment in Routine Clinical Practice | Anthony Traboulsee | Neurology | 2017 |
| MRI | LOBSTr: establishing an imaging biomarker for disease progression in multiple sclerosis. MS is a disabling neurological disease with a highly variable clinical course including acute disability (relapses when symptoms appear or worsen) and disease progression (steady accumulation of disability in the absence of relapses). There is currently no approved treatment for progressive MS. A principal pathology of MS is the destruction of myelin, which surrounds nerves to speed up signal conduction. We have developed a magnetic resonance imaging technique that provides quantitative measurements of myelin. Our aim is to establish myelin water imaging as a biomarker for disease progression, allowing efficient clinical trials to establish effective treatment options for progressive MS. | Shannon Kolind | Neurology | 2017 |
| MRI | COMB ofatumumab versus teriflunomide in patients with relapsing MS | Robert Carruthers | MS & NMO Clinical Trials Group | 2017 |
| MRI | MRI Actuator Evaluation/Liver MRE in Healthy Volunteers | Tim Salcudean | Electrical and Computer Engineering | 2017 |
| MRI | Subject-specific Mastication Modeling and its applications in Reconstructive Surgery | Sidney FELS (Amir Abdi) | Electrical and Computer Engineering | 2017 |
| MRI | Parotid functional mapping using chemical exchange saturation transfer (CEST) | Nevin McVicar / Steven Thomas | Medical Physics | 2017 |
| fMRI | EXML – Effect of aerobic exercise on neuroplasticity and motor learning post stroke | Lara Boyd | Physical Therapy | 2017 |
| MRS | Glutamate as a biomarker of pain intensity in the anterior cingulate cortex | John Kramer / Corree Laule | Blussal Spinal Cord Centre / ICORD | 2017 |
| MRI | The effects of running on knee cartilage measures in people with and without knee osteoarthritis. A pilot study | Michael Hunt | Physical Therapy | 2017 |
| MRI | Pilot Study of PET Imaging: Correlation with Advanced MRI inMS | Robert Carruthers | Neurology | 2017 |
| MRI | Advanced MRI measures of normal appearing white matter in progressive solitary sclerosis compared to primary progressive MS, relapsing-remitting MS, and healthy controls | Robert Carruthers / Shannon Kolind | Neurology | 2017 |
| MRI | Pilot Study for Myelin Water Imaging in Cervical Spinal Cord | Shannon Kolind | Neurology | 2016 |
| MRI | Biomarker Study to Explore Mechanism of Action of Ocrelizumab and B-cell Biology in MS (OBOE Study) | Robert Carruthers | MS & NMO Clinical Trials Group | 2016 |
| fMRI | MRI of Cerebrovascular Reactivity | Alex Rauscher | Paediatrics | 2016 |
| fMRI | Canadian rTMS Treatment and Biomarker Network in Depression (CARTBIND) Trial | Fidel Vila-Rodriguez | Psychiatry | 2016 |
| fMRI | Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis | Sanjay Kalra and Hannah Briemberg | Neurology | 2016 |
| fMRI | Randomized double-blind sham-controlled trial of repetitive transcranial magnetic stimulation (rTMS) for bipolar depression | Lakshmi Yatham | Psychiatry | 2016 |
| MRI | Phase III, multicentre, randomized, double-blind, placebo-controlled, parallel-Group, efficacy, and safety study of Crenezumab in patients with prodromal to mild Alzheimer's disease (ABBY 3 Study) | Ging-Yuek Robin Hsiung | Neurology | 2016 |
| MRI | Detection of metastatic brain tumours using dynamic glucose enhanced MRI after D-Glucose injection | Nevin McVicar | BCCA | 2016 |
| MRI | Advanced Quantitative Imaging in Cervical Spinal Cord | Shannon Kolind | Neurology | 2016 |
| fMRI | A Medium Chain Triglyceride INTervention for Alzheimer Disease (A MINT for AD) Phase I Study (MINT-01) | Haakon Nygaard | Neurology | 2016 |
| fMRI | Canadian Consortium for Neurodegeneration in Aging (CCNA): The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) Study | Ging-Yuek Robin Hsiung | Neurology | 2016 |
| fMRI | The SARTAN-AD Trial: A randomized, open label, proof of concept study of Telmisartan vs. Perindopril in hypertensive mild-moderate Alzheimer's disease patients | Ging-Yuek Robin Hsiung | Neurology | 2016 |
| fMRI | The ENGAGE Study: A Phase 3 Multicenter, Randomized, Double-Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer's Disease | Ging-Yuek Robin Hsiung | Neurology | 2016 |
| fMRI | A novel approach to studying postural instability in Parkinson's disease using functional Magnetic Resonance Imaging (fMRI) | Mark Carpenter | Kinesiology | 2016 |
| MRI | Importance of diffusely abnormal white matter on disability and progession in MS | Cornelia Laule | Radiology | 2016 |
| MRI | VACCINE Study | Tony Traboulsee | MS Clinical Research | 2015 |
| fMRI | Neurobiological Correlates of TMS in NHP | Doris Doudet | Neurology | 2015 |
| MRI | ARPEGGIO Study | Robert Carruthers | MS Clinical Research | 2015 |
| fMRI | Arrowsmith and mTBI | Naznin Virji-Babul | Physical Therapy | 2015 |
| MRI | TOPAZ extension study | Tony Traboulsee | MS Clinical Research | 2015 |
| MRI | Mild traumatic brain injury genotyping and phenotyping with advanced imaging, Electroencephalography, and cognitive probes (MTBI) | William Panenka | Psychiatry | 2015 |
| MRI | Reshaping the Path of Vascular Cognitive Impairment with Resistance Training | Teresa Liu-Ambrose | Physical Therapy | 2015 |
| fMRI | Yohimbine Aging and Reproducibility Study | Doris Doudet | Neurology | 2015 |
| fMRI | The Integrated Neurostimulation Platform for Neuropsychiatric Research Group - Investigating predictors of treatment response in treatment-resistant depression (TRD) with interleaved TMS/fMRI | Fidel Vila-Rodrigues | Psychiatry | 2015 |
| MRI | The AMARANTH Study: A 24-month, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Efficacy, Safety, Tolerability, Biomarker, and Pharmacokinetic Study of AZD3293 in Early Alzheimer's Disease | Gin-Yuek Robin Hsiung | Neurology | 2015 |
| fMRI | Identifying the Neurocognitive Impairments Associated with Recurrent Falling Among Community-Dwelling Seniors | Teresa Liu-Ambrose | Physical Therapy | 2015 |
| fMRI | Improving physical activity using an online monitoring tool: a new model of care for knee osteoarthritis | Teresa Liu-Ambrose | Physical Therapy | 2015 |
| fMRI | The Effect of Fit Brains Training on Cognitive Performance in Older Adults | Teresa Liu-Ambrose | Physical Therapy | 2015 |
| MRI | A Double-masked, Placebo-controlled Study with Open-label Period to Evaluate the Efficacy and Safety of MEDI-551 in Adult Subjects with Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders | Robert Carruthers | Neurology | 2015 |
| MRI | Relationship between cervical spinal cord microstructure, metabolite concentrations, and neuropathic pain after spinal cord injury | John Kramer | ICORD | 2015 |
| MRI | ISIS 443139-CSI | Blair Leavitt | Medical Genetics | 2015 |
| MRI | FYN Study: A Phase 2a Multi-Center Study of 18F-FDG PET, Safety and Tolerability of AZD0530 in Mild Alzheimer's disease | Haakon Nygaard | Clinic for Alzheimer disease and Related Disorders | 2015 |
| fMRI | Assessment of “normal appearing” white matter in Parkinson's Disease and its association with cognitive dysfunction | Alex MacKay | UBC MRI Research Centre | 2015 |
| MRI | Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS) | Ian Mackenzie | Pathology | 2015 |
| MRI | Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) | Ian Mackenzie | Pathology | 2015 |
| fMRI | Treating Depression in Parkinson's Disease with Transcranial Direct Current Stimulation | Jon Stoessl | Neurology | 2015 |
| fMRI | Black Box Theatre of the Mind | Polly Gibbons/Ron Burnett | Emily Carr University | 2015 |
| fMRI | Neurological Networks Underlying Cognition in Psychosis | Todd Woodward | Psychiatry | 2015 |
| fMRI | Brain Network Interactions | Kalina Christoff | Brain Research Centre | 2015 |
| MRI | Comparison of Aripiprazole vs Risperidone on Brain Morphology using MRI - The CARB study | Alasdair Barr | Psychiatry | 2015 |
| MRI | Feasibility Study of MR Imaging on Parotid Gland Stimulation (SPIT) | Stefan Reinsberg | Physics | 2015 |
| MRI | Tau and Neuroinflammation Imaging in Parkinson's disease and Related Disorders | Jon Stoessl | Neurology | 2015 |
| fMRI | Motor Planning Post-Stroke | Lara Boyd | Physical Therapy | 2015 |
| MRI | Post Mortem Fetal MRI | Alex Rauscher/Denise Pugash | Paediatrics | 2015 |
| MRI | Imaging Tau Accumulation with PBBH3 in Healthy Controls | Jon Stoessl | Neurology | 2014 |
| fMRI | Neural corelates of autonomic regulation in elite athletes combining heart rate viariability with fMRI | Lara Boyd | Physical Therapy | 2014 |
| fMRI | charactering the impact of silent lesions on stroke recovery using mulimodal neuroimaging | Lara Boyd | Physical Therapy | 2014 |
| MRI | Feasibility of spectroscopy and DTI in non-human primates: Pilot study for CIHR | Doris Doudet | Pacific Parkinson's Research Centre | 2014 |
| fMRI | Arrowsmith Brain Imaging | Lara Boyd | Physical Therapy | 2014 |
| MRI | The Neural Correlates of delusions of reference and recovery from delusions | Mahesh Menon | Psychiatry | 2014 |
| MRI | Efficacy of B11B019, Declizumab High Yield Process (DAC-HYP), Monotherapy in subjects with re: An Investigator-Initiated, Multicentre, Phase IV, Open-Label Study to evaluate the biological basis for susceptibility or resistance to disease progression in relapsing-remitting multiple sclerosis patients treated in routine practice with Gilenya for 5 years (IGLOO) | Tony Traboulsee | MS Clinical Research | 2014 |
| fMRI | Structural and Functional Correlates of Neuroplastic Change Associated with Stroke | Lara Boyd | Physical Therapy | 2014 |
| MRI | What is the relationship between hip musculature; knee joint alignment, pain and function in people with and without knee osteoarthritis? | Karim Khan | Centre for Hip Health and Mobility | 2014 |
| fMRI | Sensorimotor plasticity underlying the recovery of skilled walking in people with chronic incomplete SCI | Tania Tam & Lara Boyd | Physical Therapy | 2014 |
| fMRI | Characterizing the impact of silent lesions on stroke recovery using multimodal neuroimaging | Lara Boyd | Physical Therapy | 2014 |
| MRI | Acoustic Noise Measurement o Noise from single-Shot EPI | Stefan Reinsberg | Physics & Astronomy | 2014 |
| fMRI | Structural and Functional Correlates of Neuroplastic Change Associated with Stroke | Lara Boyd | Physical Therapy | 2014 |
| MRI | What is the relationship between hip musculature; knee joint alignment, pain and function in people with and without knee osteoarthritis? | Karim Khan | Family Practice | 2014 |
| MRI | A randomized controlled study of conventional versus theta-burst repetitive transcranial magnetic stimulation in the treatment of major depressive disorder | Fidel Vila-Rodriguez | Psychiatry | 2014 |
| MRE | Magnetic Resonance Elastography of the liver | Tim Salcudean | Electrical Engineering | 2014 |
| MRI | Comparative study 0.5T MR Open versus 3.0T MRI - Region of interest: knee | David Hart | Centre for Hip Health and Mobility | 2014 |
| MRI | Development of new MRI Techniques for Neuroimaging | Alex Rauscher | Radiology | 2014 |
| MRI | Medical Imaging Trial Network of Canada (MINTEC) Protocol C6: Amyloid and glucose PET Imaging in Alzheimer and Vascular Cognitive Impairment patients with significant White Matter Disease | Ging-Yuek Robin Hsiung | Neurology | 2014 |
| MRI | The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease Study - A4 | Ging-Yuek Robin Hsiung | Neurology | 2014 |
| MRI | A multi-centre, randomized, double-blind, placebo-controlled, phase 3 study to evaluate the efficacy and safety of SA237 as monotherapy in patients with neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) Chugai Pharmaceuticals Protocol #: SA-309JG | Tony Traboulsee | MS Clinical Trials | 2014 |
| fMRI | Characterizing the Functional Contribution of White Matter Systems within Distributed Neural Networks | Ryan D'Arcy | SFU | 2014 |
| MRI | Phase I/II Interventional Clinical Trial of Balloon Venoplasty for Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis (CCSVI) | Tony Traboulsee | Neurology | 2013 |
| MRS | In Vivo 31P-MR spectroscopy for evaluation of mutation load in a family with MELAS (Mitochontrail Myopathy Encephalopathy, Lactic Acidosis and Stroke like episodes | Gabriella Horvath | Adult Metabolic Diseases Clinic | 2013 |
| MRI | A phase-II randomized, double blind, parallel group, placebo-controlled, multi-centre study to evaluate the safety and efficacy of Abatacept in adults with relapsing-remitting Multiple Sclerosis | Joel Oger | Neurology | 2013 |
| fMRI | Sensorimotor plasticity underlying the recovery of skilled walkin in people with chronic incomplete spinal cord injury | Tania Lam/Lara Boyd | Physical Therapy | 2013 |
| fMRI | PBR28 in healthy controls: serotonergic innervation and Levodopa-derived Dopamine release in PD: an in vivo PET study | Vesna Sossi | Pacific Parkinson's Reasearch Centre | 2013 |
| fMRI | Exercise in Parkinson's Disease | Jon Stoessl | Pacific Parkinson's Reasearch Centre | 2013 |
| MRI | Myelin Maps ofr T1 and T2 Weighted Scans? | Alex Rauscher | Radiology | 2013 |
| fMRI | Neural Basis of Spontneous Thought | Kalina Christoff | Brain Research Centre | 2013 |
| fMRI | Regional Brain Activiation during different forms of response inhibition comparing young health adults with problem stimulant users and problem gambers | Christian Schutz | Psychiatry | 2013 |
| MRI | Cortical inhibition in unipolar and bipolar depression compared to healthy subjects: a TMS-EEG study | Lakshmi Yatham | Psychiatry | 2013 |
| MRE | FTPC: Focal Therapy for Prostate Cancer: A study using focal low dose rate brachytherapy as an alternative to active surveillance and radical treatment forfavourabe risk prostate cancer | James Morris | BC Cancer Agency | 2013 |
| MRI | Comparative study 0.5T Open MR vs 3.0T MRI: Region of interest - Knee | David Hart | Centre for Hip Health and Mobility | 2013 |
| MRI | Characterization of Dementia due to Mixed Alzheimer and subcortical vascular pathology | Robin Hsiung | Neurology | 2013 |
| fMRI | Is there a homunculus in the visual cortex? | Jason Barton | Ophthalmology | 2013 |
| MRI | Serial comparisons of abdominal and neurological MRI scans of patients with refractory pychosis disorders (SCAN MRI) | Alasdair Barr | Psychiatry | 2013 |
| MRI | DIAN-TU-001: a phase II/III randomized, double-blind, placebo-controled multi-centre study of 2 potential disease modifying therapies in individuals at risk for and with dominantly inherited Alzheimer's disease | Robin Hsiung | Neurology | 2013 |
| MRI | T2 relaxometry MRI for the diagnosis of prostate cancer | Piotr Kozlowski | UBC MRI Research Centre | 2013 |
| MRI | Development of a new imaging technique of knee cartilage in osteoarthritis | Alex Rauscher | Radiology | 2013 |
| fMRI | Exercise-induced and music-induced brain connectivity changes in Parkinson's Disease | Martin McKeown | Neurology | 2013 |
| MRI | Tractography after bilateral anterior capsulotomy | Andrew Howard | Psychiatry | 2013 |
| fMRI | Neural correlates of autonomic regulation in elite athletes combining heart rate variability with fMRI | Lara Boyd | Physical Therapy | 2013 |
| MRI | TRACK-ON | Blair Leavitt | Neurology | 2012 |
| MRI | Complications of Parkinson's Disease: The Dopamnergic Basis of Depression; Study 1 | Jon Stoessl | Neurology | 2012 |
| MRI | IMPAKT-Hip: Natural History of FAI Study | Jolanda Cibere | Orthopaedics | 2012 |
| fMRI | Effects of Exposure to Air Pollution on Congitive Function (EAPOC) | Christopher Carlsten | Respiratory Medicine | 2012 |
| fMRI | Assessment of Cerebrovascular function using MRI and Blood Gas Manipulation | William Sheel | Human Kinetics | 2012 |
| MRI | Study of Myelination in Multiple Sclerosis using MRI and MEPs | Tony Traboulsee | Neurology | 2012 |
| MRI | Pseudo-atrophy of the brain in Multiple Sclerosis (Extension) | Tony Traboulsee | Neurology | 2012 |
| fMRI | Cognitive characterization of Individuals Genetically At-Risk for Frontotemporal Dementia | Claudia Jacova | Neurology | 2012 |
| MRI | MITIGATE-HD | Blair Leavitt | Neurology | 2012 |
| FfMRI | Integrated biological markers for the prediction of treatment response in depression | Raymond Lam | Psychiatry | 2012 |
| MRI | A Phase II, multicentre, randomized, parallel-group, partially blinded, placebo and Avonex controlled dose finding study to evaluate the efficacy as measured by brain MRI lesions, and safety oftwo does regimens of ocrelizumab in patients with relapsing-remitting multiple sclerosis ROCHE WA21493C/CAT4422g | Lorne Kastrukoff | Neurology | 2012 |
| MRI | A PET study of NE Transporter Occupancy and Symptom Response in Depressed Patients Treated with Quetiapine XR | Lakshmi Yatham | Neurology | 2012 |
| fMRI | Clinical and neural funcitoning outcomes following group-based family cognitive-behaviour therapy in pediatric obsessive-compulsive disorder (OCD) | Evelyn Stewart | Paediatrics | 2012 |
| MRI | The Relationship Between Serotonergic Innervation and Levodopa-Derived Dopamine Release in Parkinson's disease: an in vivo PET Study | Jon Stoessl | Neurology | 2012 |
| MRI | Advanced MRI Measures of Repair in Ocrelizumab treated Patients | Tony Traboulsee | Neurology | 2012 |
| rs-fMRI | Effects of Brain Magnesium concentration on 31P-MRS and resting state fMRI in ParkinsonÕs disease | Martin McKeown | Neurology | 2012 |
| fMRI | Brain Activation during Motor Tasks after SCI | Janice Eng | Physical Therapy | 2012 |
| fMRI | Cortical and Subcortical Effects of Galvanic Vestibular Stimulation in Parkinson's Disease | Martin McKeown | Neurology | 2012 |
| MRI | Anatomical and functional MRI Correlates of Cognitive Dysfunction in Multiple Sclerosis | Alex MacKay | Physics & Astronomy | 2012 |
| fMRI | Neural and Biochemical Correlates of Inner Time Consciousness in Professional Swimmers | Georg Northoff | Psychiatry | 2012 |
| MRI | The Evolution of Parkinson's Disease | Jon Stoessl | Neurology | 2012 |
| MRS | A Longitudinal Comparison of Aripiprazole vs. Higher Metabolic Risk Antipsychotic Drugs on Adiposity Using MRI (CALM study) | Alasdair Barr | Psychiatry | 2012 |
| fMRI | Can exercise improve cancer associated cognitive dysfunction | Kristin Campbell | Physical Therapy | 2011 |
| MRI | A multi-centre, randomized, double-blind, placebo-controlled, parallel-group, phase II trial to investigate the efficacy and safety of weekly intra-articular (i.a.) injections of 10, 30, and 100 _g of AS902330 for three consecutive weeks in patients with acute cartilage injury of the knee | David Li | Radiology | 2011 |
| MRI | Baminercept: A Multicentre, Randomized, Blinded, Placebo-Controlled, Dose-Escalation Study to Evaluate the Penetration and Pharmacodynamic Effects of Baminercept in the CSF and Safety in Subjects with Secondary Progressive Multiple Sclerosis | Tony Traboulsee | Neurology | 2011 |
| MRI | Controlled High Risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurological Surveillance: CHAMPIONS Continuation Study | Tony Traboulsee | Neurology | 2011 |
| MRI | Interhemispheric contributions to neuroplasticity and motor learning after stroke | Lara Boyd | Rehabilitation Sciences | 2011 |
| fMRI | A double-blind, randomized, placebo-controlled, parallel-group Phase II study to explore the potential beneficial effects of safinamide on cognition in non-demented patients with idiopathic Parkinson's disease (PD) and cognitive impairment. #EMR 701165-024 | Joseph Tsui | Neurology | 2011 |
| MRI/fMRI | Neuroimaging in concussion | Alex Rauscher | Radiology | 2011 |
| fMRI | Multi-object processing in the ventral stream | Jason Barton | Ophthalmology | 2011 |
| fMRI | NeuroDevNet substudy on Fetal Alcohol Spectrum Disorder | Christian Beaulieu | Biomedical Engineering, U of A | 2011 |
| MRI | Preparation for advanced imaging at high field: Correlates in formalin fixed brain and spinal cord | Cornelia Laule/Wayne Moore | Pathology & Laboratory Medicine | 2011 |
| MRI | Neuroimaging in high altitude climbers | Alex Rauscher | Radiology | 2011 |
| fMRI | The effects of nabilone on cue-triggered neural response: Exploring treatment options for cannabis abuse | Elton Ngan | Psychiatry | 2011 |
| MRI | Duration of changes in intracortical excitability and cerebral diffusion after transient ischemic attack | Lara Boyd | Rehabilitation Sciences | 2011 |
| MRI | A long-term follow-up study of oral ELND005 (AZD-103) in subjects with Alzheimer's Disease | Robin Hsiung | Neurology | 2011 |
| MRI | Alzheimer's Disease neuroimaging initiative 2 (ADNI 2) | Ging-Yuek Robin Hsiung | Neurology | 2011 |
| MRI | Concussion in youth ice hockey: New frontiers in diagnostic imaging | Naznin Virji-Babul | Physical Therapy | 2011 |
| fMRI | The contribution of face parts to face processing | Jason Barton | Ophthalmology | 2011 |
| fMRI | Metacognitive Monitoring of Attention | Kalina Christoff | Brain Research Centre | 2011 |
| MRI | In Vivo 3-D hip kinematics based on MR Images from patients with femoro-acetabular impingement | Antony Hodgson | Orthopaedic Engineering | 2011 |
| MRI | A Phase III, multicentre, randomized, parallel-group, double-blinded, placebo controlled study to evaluate theefficacy and safety of Ocrelizumab in adults with primary progressive Multiple Sclerosis | Tony Traboulsee | Neurology | 2011 |
| fMRI | Multimodal functional neuroimaging of the networks underlying cognitive impairment in schizophremia | Todd Woodward | Psychiatry | 2011 |
| MRI | Magnetic Resonance Elastography of paitents with prostate cancer | Tim Salcudean | Electrical Computer Engineering | 2011 |
| MRI | Psychosis, Exercise and Hippocampal Plasticity | Donna Lang | Psychiatry | 2011 |
| MRS | A double-blind, double-dummy, parallel-group study to evaluate the efficacy and safety of Ocrelizumab in comparison to Interferon Beta-1a (Rebif) in patients with Relapsing Multiple Sclerosis ROCHE WA21093/A | Tony Traboulsee | Neurology | 2011 |
| MRI | DASB Pilot Study | Jon Stoessl | Neurology | 2011 |
| MRS | A Multi-centre, randomized, double-blind, placebo-controlled, study of the efficacy of Natalizumab on reducing disability progression in subjects with secondary progressive Multiple Sclerosis | Virgina Devonshire | Neurology | 2011 |
| fMRI | White Matter reorganization in response to motor skill training | Lara Boyd | Physical Therapy | 2011 |
| MRI | Compartmentalization of the human neck muscles sternocleidomastoid and splenius capitis | Jean-Sebastien Blouin | Human Kinetics | 2010 |
| MRI | TEVA Mega Study - Remyelination in MS with Glatiramer Acetate: Insights from Myelin Water imaging and evoked potentials | Alex MacKay | Physics & Astronomy | 2010 |
| MRI | Three-dimensional measurement of knee kinematics in vivo: applications to knee pain and osteoarthritis - in vivo studies, validation b | Dave Wilson | Orthopaedic Engineering | 2010 |
| fMRI | Integration of cognitive control and motivational information | Kalina Christoff | Brain Research Centre | 2010 |
| MRI | Specialized anatomy of baleen whales | Robert Shadwick | Department of Zoology | 2010 |
| fMRI | Expression versus identity processing n the core and extended face networks | Jason Barton | Ophthalmology | 2010 |
| fMRI | Role of exercise on cognition and function in seniors with vascular cognitive impairment | Lara Boyd | Physical Therapy | 2010 |
| MRI | T1 mapping by 3D T1FFE with variable flip angles for dGEMRIC | Dave Wilson | Orthopaedic Engineering | 2010 |
| MRS | A Double-Blind, Placebo-Controlled Study of the safety and Efficacy of ONO-4641 in patients with relapsing Remitting Multiple Sclerosis. | Tony Traboulsee | MS Clinical Research | 2010 |
| fMRI | Is there a homunculus in the fusiform gyrus? | Jason Barton | Ophthalmology | 2010 |
| fMRI | Functional Connectivity in Motion-Sensitive Visual Cortex | Kalina Christoff/Debbie Giaschi | BRC/Ophthalmology | 2010 |
| MRI | Fetal Alcohol Disorders: Gene-environment interactions, predictive biomarkers, and the relationship between structural alterations in the brain and functional outcomes | Christian Beaulieu | University of Alberta | 2010 |
| fMRI | Cerebellar Influences in ParkinsonÕs Disease | Martin McKeown | Neurology | 2010 |
| MRI | Relationship beween myelin water fraction and electrophysiology of normal white matter within the corpus callosum and the corticospinal tract | Alex MacKay | Physics & Astronomy | 2010 |
| MRI | Development of MRE system for prostate cancer imaging | Tim Salcudean | Electrical Computer Eng | 2010 |
| fMRI | NSDHL mutations, cholesterol metabolism and working memory: neural underpinnings | Todd Woodward/Cornelius Boerkoel | Psychiatry | 2010 |
| MRI | Alzheimer's disease neuroimaging protocol - Grand Opportunity (ADNI-GO) | Robin Hsiung | Neurology | 2010 |
| MRI | The Role of CCSVI in Multiple Sclerosis | Tony Traboulsee | Neurology | 2010 |
| fMRI | Neural networks involved in working memory in Schizophrenia | Woodward | Psychiatry | 2010 |
| MRI | Effects of atypical antipsychotics on metabolism, adiposity and weight gain in children and adolescents | Alasdair Barr | Psychiatry | 2010 |
| MRI | A dose blinded extension study to the CBAF312A2201 study to evaluate long-term safety, tolerability and efficacy of BAF312 given orally once dialy in patients with relapsing multiple sclerosis CBAF312A2201E1 Novartis | Joel Oger | Neurology | 2010 |
| MRI | DECIDE: a phase 3 multicentre, double-blind, randomized, parallel-group, monotherapy, active-control study to determine the efficacy and safety of Daclizumab High Yield Process (DAC HYP) versus Avonex (Iinterferon_-1a) in patients with relapsing-remitting multiple sclerosis Protocol #: 205MS301 Biogen Idec | Tony Traboulsee | Neurology | 2010 |
| MRI | ELND002: a phase 1b, dose-escalating, randomized, placebo-controlled, double-blinded study to evaluate the safety and efficacy of subcutaneous ELND002 in patients with relapsing forms of Multiple Sclerosis Protocol # ELND002-MS103 Elan Pharmaceuticals Inc | Tony Traboulsee | Neurology | 2010 |
| MRI | Hepatobiliary imaging in potential living liver donors: Application of high field strength MRI and Primovist contrast agent. | Audrey Spielmann | Radiology | 2010 |
| fMRI | Functional Magnetic Resonance Imaging (fMRI) cortical responses in women with overactive bladder before and after pelvic floor therapy. | Lynn Stothers | Urologic Sciences | 2010 |
| MRI | Use of Magnetic Resonance venography to characterize Multiple Sclerosis and other white matter pathologies | Alex Rauscher/Tony Traboulsee | UBC MRI Research Centre | 2009 |
| MRI | Assessment of hydration effects on MRI measures of spinal cord volume | Roger Tam/Tony Traboulsee | MS/MRI Research Group | 2009 |
| MRI | Project to develop a surgical probe for left atrial appendage occlusion surgeries | Jonathan Nakane | Engineering Physics | 2009 |
| MRI | Development and validation of a new model of Parkinson's Disease | Doris Doudet | Neurology | 2009 |
| MRS | In vivo phosphorus magnetic resonance spectroscopy of the muscle in two siblings with unexplained muscle weakness | Sylvia Stockler-Ipsiroglu | Biochemical Diseases Clinic, BCCH | 2009 |
| fMRI | Visual and verfbal problem solving | Kalina Christoff | Brain Research Centre | 2009 |
| fMRI | Enhancing cognitive vitality and functional independence in older adults with mild cognitive impairment: A randomized trial of aerobic vs. resistance training | Teresa Ambrose, Todd Handy | Centre for Hip Health | 2009 |
| fMRI | Identifying the neurocognitive impairments associated with recurrent falling among community-dwelling seniors | Teresa Ambrose, Todd Handy | Centre for Hip Health | 2009 |
| fMRI | Role of supplementary motor rea in motor imagery and motor function in idndividuals with Parkinson Disease | Lara Boyd | School of rehab sciences | 2009 |
| fMRI | doing two things at once: how does age influence tasks which challenge both mobility and cognition? | Lara Boyd | School of rehab sciences | 2009 |
| MRS | Novartis Pharmaceuticals Canada Inc. Protocol #CBAF312A2201 | Joel Oger | Neurology | 2009 |
| MRI | Kinematics and muscle activation of the cervical spine during vehicle rollover accidents | Peter Cripton | Orthopaedic Engineering | 2009 |
| fMRI | Cortical-STN functional connectivity in Parkinson's disease | Martin McKeown | Neurology | 2009 |
| fMRI | Inspiratory Muscke Trainingto Improve Respiratory and |neural function in Peoplewith Stroke | Lara Boyd | School of rehab sciences | 2009 |
| fMRI | Controlling Nicotine Craving through down-Regulation of the Insular Cortex | Kalina Christoff | Brain Research Centre | 2009 |
| MRI | Genzyme Substudy | Tony Traboulsee | MS Clinical Research | 2009 |
| MRS | Roche Genetech study WA21493/ACT4422g | Tony Traboulsee | MS Clinical Research | 2009 |
| MRS | Minocycline (CIS) | Tony Traboulsee | MS Clinical Research | 2009 |
| fMRI | Real-Time Experience Sampling | Kalina Christoff | Brain Research Centre | 2009 |
| fMRI | Studies on Music Processing in Persons with Alzheimer Disease | Ging-Yuek Robin Hsiung | Neurology | 2009 |
| MRI | PREDICT-HD v.2.0 | Lynn Raymond | Neurological Sciences | 2009 |
| MRI | IMAX Study: Maximal simultaneous boost: A dose-escalation study using a maximal simultaneous intraprostatic boost with RapidArc intensity modulated radiotherapy in intermediate risk prostate cancer | W. James Morris | BC Cancer Agency | 2009 |
| fMRI | Studies of Treatment Related Compulsive Behaviours and Impulse Control Disorders in Parkeinson's Disease | Vesna Sossi | Pacific Parkinson's Reasearch Centre | 2009 |
| MRI | Imaging Dizziness using 3T MRI | John Phillips | Otology & Neurotology, St. Paul's Hospital | 2009 |
| MRI | A Phase 3, Multicenter, Randomized, double Blind, Placebo-Controlled, Parallel Group, Efficacy and Safety Trial of Bapineuzumab (AAB-001, ELN115727) in Subjects with Mild to Moderate AlzheimerÕs disease who are Apolipoprotein E 4 Non-Carriers | Ging-Yuek Robin Hsiung | Neurology | 2009 |
| MRI | A Clinical evaluation for the management of patients with major depressive disorder, single or recurrent episode, with deep brain stimulation | Raymond Lam | Psychiatry | 2009 |
| MRI | Neuropsychological and neuropathological outcome from concurrent alcohol use and traumatic brain injury: a longitudinal study | Rael Lange | Riverview | 2009 |
| MRI | Abdominal shift due to patient position | Tim Salcudean | Electrical Computer Eng | 2009 |
| MRI | Sports related knee injury Pilot (SKIP) | Jolanda Cibere | Arthritis Research Centre | 2009 |
| MRI | Changes to skeletal muscle structure during contractions | James Wakeling | Biomedical Physiology and Kinesiology SFU | 2009 |
| MRI | Anatomical and diffusion imaging of the human arm | Dinesh Pai | Computer Science | 2008 |
| MRI | The Effect of PerthesÕ Disease on Hip Cartilage | Kishore Mulpuri | Paediatric Orthopaedics | 2008 |
| fMRI | Brain systems involved in belief formation and re-evaluation | Todd Woodward | Psychiatry | 2008 |
| MRS | A Randomised, Double-Blind, Placebo-Controlled, Dose-Ranging Safety and Efficacy Study of Oral ELND005(AZD-103) in AlzheimerÕs Disease | Howard Feldman | Neurology | 2008 |
| fMRI | Neuroimaging and Quality of Life of Children with Developmental Coordination Disorder | Lara Boyd | Rehabilitation Sciences | 2008 |
| fMRI | An FMRI Investigation of Mindfulness | Kalina Christoff | Psychology | 2008 |
| MRI | Cognitive Characterization of Individuals genetically at risk for frontotemporal dementia | Kalina Christoff | Psychology | 2008 |
| MRI | PET studies of Dopamine Turnover and release in Biolar disorder Fluorodopa PET Study | Lakshmi Yatham | Psychiatry | 2008 |
| MRI | Effects of excitatory and inhibitory transcranial magnetic stimulation on motor sequence learning | Lara Boyd | Rehabilitation Sciences | 2008 |
| MRI | Development of motor function assessment technology based on computed myography (CMG) | Dinesh Pai | Computer Science | 2008 |
| MRI | Visualization and Real-Time Dosimetry for Prostate Brachytherapy | Tim Salcudean | Electrical Computer Eng | 2008 |
| MRI | AIM-HIGH Carotid Study | Alex MacKay | Physics and Astronomy | 2008 |
| MRI | Pseudoatrophy of the Brain | Tony Traboulsee | Neurology | 2008 |
| fMRI | the Ultimatum Game | Elton Ngan | Psychiatry | 2008 |
| MRI | Hotel: Co-occurring psychosis, addiction and viral infection | Bill Honer | Psychiatry | 2008 |
| MRI | Investigation of intervertebral disc height in REM nd nonREM sleep | Jerome Fryer | 2008 | |
| MRI | Spatial and Temporal Aspects of Force Production in ParkinsonÕs Disease: Functional Magnetic Resonance Imaging Study - SWI sequence study | Alex Rauscher | UBC MRI Research Centre | 2008 |
| fMRI | Waking Salivary Cortisol and DHEA and Serum BDNF Levels in Mood Disorders (the fMRI component) | Allan Young/Mario Liotti | Mood disorders Centre | 2008 |
| MRS | Serono - Atacicept Protocol 28156 | Peter Reickmann | MS Clinical Resarch | 2008 |
| Centocor Study - a phase 2 double blind, placebo-controlled randomized, dose-ranging study of multiple subcutaneous injections of human monoclonal antibody to 1L-12P40 in subjects with relapsing-remitting multiple sclerosis | Tony Traboulsee | 2008 | ||
| fMRI | Neuroplasticity following sensory therapy in spinal cord injury | Jaimie Borisoff | GF Strong Rehab Centre | 2008 |
| MRI | Genzyme Study (2 parts) | Tony Traboulsee | Neurology | 2008 |
| fMRI | Neural correlates of cognitive and motor object representations | Todd Handy | Psychology | 2008 |
| MRI | Morphology and dimensions of small pig sinal cord and canal in vivo | Peter Cripton | Orthopaedic Engineering | 2008 |
| fMRI | Brain Activation: from mechanisms to mobility | Janice Eng | Rehab Sciences | 2008 |
| fMRI | How Does Excitatory rTMS influence motor cortical activation? | Lara Boyd | Rehab Sciences | 2008 |
| MRI | MRI and Mathematics | Linda Siegel/Christian Beaulieu | Biomeidcal Engineering U of A | 2008 |
| fMRI | The Effect of Resistance Training on Cognitive Performance, Cortical Plasticity, and Fall Risk in Women Aged 65 to 75 Years Old: A 12-Month Randomized Controlled Trial. | Teresa Ambrose, Todd Handy | Centre for Hip Health | 2008 |
| 3T vs 1-5T Comparison for imaging myelin water | Alex MacKay | 2004 | ||
| MRS | N-acetyl-aspartate measures in the thalamus in first episode schizophrenia before and after exposure to atypical antipsychotics during the early phases of treatment | Donna Lang | Radiology | 2004 |
| fMRI | fMRI Studies in ParkinsonÕs Disease | Martin McKeown | Neurology | 2004 |
| MRI | 3T MRI for Functional Neurosurgery | Chris Honey | Neurology | 2004 |
| fMRI | Money matters: An fMRI investigation of the differential response patterns to varying levels of financial reward in healthy people, and patients with schizophrenia | Elton Ngan | Psychiatry | 2004 |
| fMRI | Hippocampo-Prefrontal Connectivity during Semantic Reactivation and during Source Monitoring | Todd Woodward | Psychiatry | 2004 |
| MRS | A Pilot Clinical Trial of Intravenous Infusion of Autologous Hematopoietic Progenitor Cells in Patients With Amyotrophic Lateral Sclerosis (ALS) | Andy Eisen | Neurology | 2004 |
| fMRI | Mechanisms of Attention Orienting | Todd Handy | Psychology | 2004 |
| MRS | A prospective study of clinical outcome, brain morphology, cognitive and other functional outcomes in patients after a first episode of mania | Lakshmi Yatham | Psychiatry | 2004 |
| fMRI | Hippocampo-prefrontal connectivity | Todd Woodward | Psychiatry | 2004 |
| fMRI | New sensory tests for the early detection of dyslexia | Debbie Giaschi | Opthamology | 2004 |
| fMRI | Low- and high-level motion processing in children with anisometropic or strabismic amblyopia | Debbie Giaschi | Opthamology | 2004 |
| MRI | Linking Mechanical Imaging with Direct Measurements of BoneÕs Mechanical Properties. | Heather McKay | Orthopaedic Engineering | 2004 |
| MRS | A Multi-Centered, Randomized Double-Blind, Placebo-Controlled, Parallel Study, Assessing the Add-on effect of Minocycline in Relapsing-Remitting Multiple Sclerosis (RR-MS) Subjects Treated with Glatiramer Acetate (GA): TEVA 9014 Study | Tony Traboulsee | Neurology | 2004 |
| MRI | Neuromuscular control of the head and neck in multidirectional seated perturbations. | Timothy Inglis | Human Kinetics | 2004 |
| MRI | A biomechanical study of the Dynesys system for flexible posterior stabilization of the lumbar spine: Investigation of facet joint contact under flexion and extension loads using imaging | Tom Oxland | Orthopaedic Engineering | 2004 |
| fMRI | The cortical networks of real world memory retrieval | Todd Handy | Psychology | 2004 |
| fMRI | Retinoptic Selection as a Factor in Cortical Processing | Todd Handy | Psychology | 2004 |
| MRI | A randomized Controlled Trial of a Prevention Strategy for Severe Knee Injury in Youth Soccer. | John Esdaile | Rheumatology | 2004 |
| MRI | Three dimensional alignment and early cartilage degeneration in femoroacetabular impingement syndrome | David Wilson | Orthopaedic Engineering | 2004 |
| fMRI | Brain Mechanisms Underlying Human Motion Perception | Debbie Giaschi | Opthamology | 2004 |
| fMRI | Functional Neuroimaging of Negative Effect in Elite Swimmers | Elton Ngan | Psychology | 2004 |
| fMRI | Disease markers and predictors of clinical relapse in Remitted Unipolar Depression: An fMRI study | Raymond Lam | Psychiatry | 2004 |
| MRI | Quantitative Assessment of the Functional Adaption of Bone and Cartilage at the Glenohumeral Joint of Manual Wheelchair Users | David Wilson | Orthopaedic Engineering | 2004 |
| MRI | Nondestructive characterization and modelling of bacterial wood | Sencer Alkan | Forintek Canada Corp | 2004 |
| MRI | 3D Modelling of the Human Vocal Tract Ð Initial Investigation | Sydney Fels | Electrical Computer Eng | 2004 |
| fMRI | Spontaneous forms of thought: an fMRI investigation | Kalina Christoff | Psychology | 2004 |
| MRS | A Double-Blind, Placebo-Controlled Multicentre Study to Evaluate the Efficacy and Safety of MBP8298 in Subjects with Secondary Progressive Multiple Sclerosis. | Tony Traboulsee | Neurology | 2004 |
| fMRI | Abstract versus concrete thought during anagram completion: an fMRI investigation | Kalina Christoff | Psychology | 2004 |
| MRI | Alzheimer Disease Neuroimaging Initiative | Howard Feldman | Neurology | 2004 |
| fMRI | A Functional MRI Study of Face Perception in normal subjects, prosopagnosic patients, and patients with Cerebral Infarcts. | Jason Barton | Opthamology | 2004 |
| MRS | The UBC HuntingtonÕs Disease NMR Spectroscopy Study | Blair Levitt | Neurology | 2004 |
| MRI | Three-dimensional measurement of knee kinematics in vivo: applications to knee pain and osteoarthritis Ð ex vivo cadaver studies | David Wilson | Orthopaedic Engineering | 2004 |
| fMRI | Spatial and Temporal Aspects of Force Production in ParkinsonÕs Disease: Functional Magnetic Resonance Imaging Study | Martin McKeown | Neurology | 2004 |
| fMRI | Functional Neuroimaging of the Hippocampo-Prefrontal Neural System across the Spectrum of Schizophrenia | Todd Woodward | Psychiatry | 2004 |
| fMRI | Functional Neuroimaging of the Effects of Template Complexity in Visual Search | Vince Di Lollo | Psychiatry | 2004 |
| MRI | DW and DCE MRI in prostate cancer diagnosis - a volunteer study | Piotr Kozlowski | Radiology | 2004 |
| MRS | A Double-Blind, Placebo-Controlled Multicentre Study to Evaluate the Efficacy and Safety of MBP8298 in Subjects with Secondary Progressive Multiple Sclerosis. | Tony Traboulsee | Neurology | 2004 |
| fMRI | Somatotopy of Speech Motor Cortex | Elton Ngan | Psychiatry | 2004 |
| fMRI | A combined fMRI/DTI analysis of the cerebral motion pathways. | Jason Barton | Opthamology | 2004 |
| MRI | Neuropsychological and neuropathological effects of acute vs chronic alcohol consumption: Outcome from traumatic brain injury | Rael Lange | Riverview | 2004 |
| MRI | Evaluation of delayed gadolinium enhanced magnetic resonance imaging (dGEMRIC) as a more sensitive measure of intervertebral disc degeneration. | David Wilson | Orthopaedic Engineering | 2004 |
| fMRI | Using real-time fMRI feedback in patients with recurrent unipolar depression | Kalina Christoff | Psychology | 2004 |
| fMRI | Working memory representations at different levels of abstraction: an fMRI investigation | Kalina Christoff | Psychology | 2004 |
| fMRI | Attention in a Dynamic World: Influences of the Optic Flow Field on Visuospatial Attention | Todd Handy | Psychology | 2004 |
| fMRI | The Neural Basis of Vocal Imitation | Steven Brown | SFU | 2004 |
| fMRI | Low-level and High-level Motion Processing in Amblyopic Children | Deborah Giaschi | Opthamology | 2004 |
| fMRI | Functional Neuroimaging of the Frontal Lobe during Cognitive Flexibility Tasks | Elton Ngan, Todd Woodward | Riverview | 2004 |
| MRI | Effects of hydration status on magnetic resonance imaging measurements of brain volume and water content. | Tony Traboulsee | Neurology | 2004 |
| MRI | New Imaging and Diagnostic Modalities: A Novel Quantitative Magnetic Resonance Imaging Technique for the Assessment of Cervical Spondylotic Myelopathy | Armin Curt | Neurology | 2004 |
| fMRI | Mapping networks subserving sequential and associative decision making processes | Elton Ngan | Psychiatry | 2004 |
| fMRI | Working memory representations at different levels of abstraction: an fMRI investigation | Kalina Christoff | Psychology | 2004 |
| fMRI | Compensatory Brain Activation after Stroke | Lara Boyd | Rehabilitation Sciences | 2004 |
| fMRI | Force Production in individuals with stroke or spinal cord injury using functional magnetic resonance imaging | Janice Eng | Rehabilitation Sciences | 2004 |
| fMRI | The Effect of Resistance Training on Cognitive Performance, Cortical Plasticity, and Fall Risk in Women Aged 65 to 75 Yead Old: A 12-Month Randomized Controlled Trial | Teresa Ambrose, Todd Handy | Rehabilitation Sciences | 2004 |
| fMRI | Investigating prefrontal cortex functions using real-time fMRI | Kalina Christoff | Psychology | 2004 |
| fMRI | An fMRI Investigation of Rest | Kalina Christoff | Psychology | 2004 |
| fMRI | The neural basis of deductive reasoning errors in schizophrenia | Elton Ngan | Psychiatry | 2004 |
| fMRI | Topographical Disorientation in Brain Damaged Patients. | Jason Barton | Opthamology | 2004 |
| MRI | Sequence Development for Musculoskeletal Applications in the Knee and Hip | David Wilson | Orthopaedic Engineering | 2004 |
| MRI | Effect of acetabular labral tears, repair and resection on hip cartilage loading: A 7T MR study | David Wilson | Orthopaedic Engineering | 2004 |
| MRI | Monitoring stereotactic radiotherapy treatment of acoustic neuromas | Stefan Reinsberg | Physics and Astronomy | 2004 |
| MRI | Axial Strain Estimation in Tissue Phantoms | Dinesh Pai | Computer Science | 2004 |
| MRI | The effect of infection following ACL reconstruction on cartilage health | David Wilson | Orthopaedic Engineering | 2004 |
| MRI | Dividing the undivided: Cardiac dynamics of leatherback and green turtles | David Jones | Zoology | 2004 |
| MRI | Impaction allografting - MR imaging for the bone cement morphology in a cadaveric femur model | Tom Oxland | Orthopaedic Engineering | 2004 |
| fMRI | Multi-Site Pediatric Network for fMRI Mapping in Childhood Epilepsy | Bruce Bjornson | Neurology | 2004 |
| MRI | Characterising Myelination in Multiple Sclerosis | Alex MacKay | Radiology | 2004 |
| MRI | In vivo electrophysiological evaluation of DTI depiction of the deep seated principle motor pathways in human brain. A clinical 3T mRI and functional sterotaxy study | Chris Honey | Neurology | 2004 |
| fMRI | Neurological Changes with Motor Learning | Nicola Hodges | Human Kinetics | 2004 |
| MRI | Early Hip Osteoarthritis MRI Pilot: dGEMRIC Substudy | Jolanda Cibere | Rheumatology | 2004 |
| MRI | Protocol Development for Diffusion Tensor Imaging of the Human Forearm | Dinesh Pai | Computer Science | 2004 |
| MRI | Neuropsychological and neuropathological effects of acute versus chronic alcohol consumption on outcome of traumatic brain injury | Rael Lange | Riverview | 2004 |
| fMRI | The cortical basis of motion perception deficits in amblyopia | Debbie Giaschi | Opthamology | 2004 |
| MRI | TRACK-HD | Blair Levitt | Neurology | 2004 |
| fMRI | The cortical basis of reading and temporal processing deficits in dyslexia | Debbie Giaschi | Opthamology | 2004 |
| fMRI | Does cortical stimulation facilitate motor learning after stroke? | Lara Boyd | Rehabilitation Sciences | 2004 |
| MRI | Alasdair Barr | Psychiatry | 2004 | |
| fMRI | The Neuronal Basis of Developmental Stuttering | Mario Liotti | SFU Psychology | 2004 |
| fMRI | An NMR Investigation of Pedophilia | Kalina Christoff | Psychology | 2004 |
| MRI | Dynamic 3D upper airway modeling of the effect of oral appliances for the treatment of obstructive sleep apnea/hypopnea | John Fleetham | Respiratory Medicine | 2004 |
| fMRI | Recovery after stroke: what is the role of the undamaged, contralesional cortex? | Lara Boyd | Rehabilitation Sciences | 2004 |
| MRI | Which white matter tracts are involved in distinct psychiatric and surgically treated disorders ? | Chris Honey | Neurology | 2004 |
| fMRI | The neural basis of deductive reasoning errors in schizophrenia: Conflict and emotion | Elton Ngan | Psychiatry | 2004 |
| fMRI | Integration of disconfirmatory evidence in pychosis: Cognitive and Neural findings | Todd Woodward | Psychiatry | 2004 |