Approved Projects on the 3T Philips Scanner

MRIVERTEX - A Phase 1/2 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-264 in Subjects With Type 1 Diabetes Mellitus (Protocol # VX22-264-101).

This study is investigating if experimental devices implanted in the preperitoneal space can reduce or eliminate the need for individuals with Type 1 diabetes mellitus to take insulin.
David ThompsonEndocrinology2024
MRI, DTI, rs-fMRI, UFE, FGATIREffectiveness of targeting the Zona Incerta (ZI) for tremor control in Parkinson's disease patients.

We propose that direct neuromodulation of the Zona Incerta (ZI) using low-intensity ultrasound (LIFU) could yield effects similar to Magnetic Resonance-guided Focused Ultrasound (MRgFUS) ventral intermediate nucleus (Vim) thalamotomy for tremor control in Parkinson's disease (PD). The specific aims involve evaluating the ZI as a potential target for tremor suppression, comparing its effectiveness to targeting the Vim, and investigating the functional mechanisms of ZI-LIFU and Vim-LIFU. The research plan outlines recruiting 20 PD participants for a crossover randomized controlled trial with the order of stimulation types (ZI-LIFU/Vim-LIFU) randomized across two study groups.
Martin McKeownNeurology2024
MRI, SWIFREVIVA - A randomized, double-blind, Phase 3 study comparing efficacy and safety of frexalimab (SAR441344), EFC17504, to placebo in adult participants with nonrelapsing secondary progressive multiple sclerosis.

A randomized, double-blind, Phase 3 study comparing efficacy and safety of frexalimab (SAR441344) to placebo in adult participants with nonrelapsing secondary progressive
multiple sclerosis.
Virginia DevonshireNeurology2024
MRI, FLAIRFREXALT - Master protocol of two independent, randomized, double-blind Phase 3 studies comparing efficacy and safety of frexalimab (SAR441344), EFC17919, to teriflunomide in adult participants with relapsing forms of multiple sclerosis.

The purpose of this study is to measure the annualized relapse rate (ARR) with administration of frexalimab compared to a daily oral dose of teriflunomide in male and female participants with relapsing forms of multiple sclerosis.
Alice Schabas
MRI, DTI, FLAIR, rs-fMRISimulating brain tumor resection to optimize onco-functional balance in low-grade glioma.

We are assessing the relationship between personalized whole brain dynamical models and cognitive outcomes in patients with Low-Grade Gliomas.
Stefan LangNeurosurgery2024
MRI, DTI, rs-fMRISimultaneous deep brain stimulation and fMRI.

We are performing simultaneous deep brain stimulation and functional MRI. This technique will allow us to investigate the network basis of deep brain stimulation.
Stefan LangNeurosurgery2024
MRI, SWI, FLAIRA Phase 3, randomized, double-blind, efficacy and safety study comparing SAR442168 to placebo in participants with primary progressive multiple sclerosis (PERSEUS).

This study will evaluate the efficacy of SAR442168 compared to placebo in delaying disability progression in PPMS and on clinical endpoints such as MRI lesions, cognitive performance, physical function, and quality of life.
Alice Schabas Neurology2024
MRI, DWI, MREA Phase 2a, Randomized, Placebo-contolled, Double-blind Study to Assess the Safety, Pharmacokinetics, Pharmacodynamicz of AGMB-129 in Patients with Fibrostetonic Crohn’s Disease.

The study evaluates the safety and biological activity of an experimental product called “AGMB-129” in patients with fibrostenotic Crohn’s Disease. This is a type of CD where there is fibrosis or scarring on the internal surface of bowels that results in narrowing of the bowel.
Brian BresslerGastroenterology2024
MRI, FLAIR, DTI, Magnetization Transfer, QRM, SWIAMBRA - Assessment of Microstructural Brain Alterations. Assessment of myelin content and tissue microstructure in multiple sclerosis: a repeated MRI study.

AMBRA is a pilot study across 6 universities internationally working to implement and evaluate a harmonized MRI protocol optimized to assess myelin across multiple scanner platforms.
In combination with fluid biomarkers, the goal is to be able to create an MRI protocol that could be implemented in clinical trials for multiple sclerosis (MS) that would be sensitive to changes in myelin as a result of pathology and treatment response.
Shannon KolindNeurology2023
MRI, FLAIR, DWI, Angiography, QRM, Perfusion- ASL, SWI Hotel-TANDEM study - (Hotel Phase 3) - Traumatic brain injury and cerebral small vessel disease in a vulnerably housed cohort, a prelude to early neurodegeneration and dementia.

Hotel-TANDEM is the third phase of our longitudinal investigation of the intersection of mental illness, addiction and traumatic brain injury. This phase of research will be focused on exploring the trajectories of cognitive functioning in relation to traumatic brain injuries in a vulnerable population with high rates of cerebrovascular deficits, comorbid addiction, mental illness and overdose, in the context of aging.
Will Panenka, Donna LangNeuropsychiatry
MRI, FLAIRADNI-4 (Alzheimer's Disease Neuroimaging Initiative -4).

ADNI4 is a non-randomized non-treatment natural-history study with a goal of determining the relationships among the clinical, cognitive, imaging, genetic and biochemical biomarker characteristics of the entire spectrum of Alzheimer's disease (AD), as the pathology evolves from normal aging through very mild symptoms, to mild cognitive impairment (MCI), to dementia (DEM). ADNI4 continues the previously funded AD Neuroimaging Initiative (ADNI1, ADNI-GO, ADNI-2 and ADNI3), and will continue to inform the neuroscience of AD, identify diagnostic and prognostic markers, identify outcome measures that can be used in clinical trials, and help develop the most effective clinical trial scenarios.
Robin HsiungNeurology2023
MRI, FLAIRA Phase 2a, Randomized, Placebo-Controlled, Dose-Ranging Study to Evaluate the Safety and Efficacy of PTC518 in Subjects with Huntington’s Disease.

Medicine is available to help with the symptoms of Huntington disease (HD), but currently there is no treatment that can prevent the disease or delay the physical, mental and behavioral symptoms it causes. HD is caused by the presence of a toxic mutant huntingtin (mHTT) protein. There is research evidence to support the idea that lowering mHTT protein should slow the progression of HD. This study is testing the experimental drug called PTC518, whether it can slow the progression of HD by reducing the production of mHTT.
Blair LeavittCentre for Huntington Disease
MRI, FLAIR, QRM, DWIA Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Efficacy, Safety, and Tolerability of BIIB080 in Subjects with Mild Cognitive Impairment Due to Alzheimer’s Disease or Mild Alzheimer’s Disease Dementia
(CELIA Study).

The purpose of the CELIA study is to look at whether BIIB080 (the study drug) can help people with Alzheimer's disease, how safe it is, and how the body handles taking it (known as tolerability). The study will have 3 periods: Screening period (about 9 weeks), Treatment period (76 weeks or approximately 18 months), and Follow-up period (20 weeks or 5 months). Study procedures will include: Administration of the study drug or placebo via lumbar puncture, CSF sampling, questionnaires, cognitive assessments, MRI brain scan, electrocardiogram (ECG), blood and urine collection, neurological exam, physical exam, vital signs, questions about medical history and changes in medication.

Website Link: https://card.med.ubc.ca/research/

Robin HsiungNeurology2023
MRI, FLAIR, QRM, DWIA Phase 3b/4 Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Verify the Clinical Benefit of Aducanumab (BIIB037) in Participants with Alzheimer’s Disease (Biogen ENVISION study).

The Biogen ENVISION study is a double-blind, placebo-controlled, longitudinal study that aims to verify the long-term safety and efficacy of monthly infusions of the investigational drug aducanumab compared with placebo in people with Alzheimer disease (AD). The study includes magnetic resonance imaging (MRI), positron emission tomography (PET, optional), electrocardiography (ECG), blood sampling, cerebral spinal fluid (CSF) sampling (optional), neuropsychological testing, and caregiver interviews to assess the effects and safety profile of aducanumab.

Website Link: https://card.med.ubc.ca/research/
Robin HsiungNeurology2023
MRIIntegrative imaging of marine mammals: adaptations for feeding and diving in whales and enhanced post mortem examination procedures.

The Shadwick lab specializes in functional morphology of cetaceans (whales, dolphins and porpoises) with a particular interest in the aerodigestive pathway. In addition to dissection of gross specimens from stranded and hunter harvested animals, diagnostic imaging (CT and MR) has proved invaluable in advancing the current knowledge of mammalian adaptation to the marine environment. Whole body imaging of seals, sea lions and sea otters is also pursued to develop and better define the application of Lidar for health assessments of free ranging and nutritional condition of dead stranded marine mammals.
Robert ShadwickZoology2023
MRI, rs-fMRI, tb-fMRI, DTI, QRMThe role of a personalized music intervention towards alleviating apathy in Parkinson’s Disease.

Apathy is a common neuropsychiatric disturbance that manifests in approximately a quarter of patients in early stages of Parkinson’s Disease (PD). Music-based interventions have been shown to alleviate apathy in other clinical populations; the mechanisms, however, of how music carries out its anti-apathetic effects, especially in Parkinson’s Disease, are poorly elucidated. This study aims to examine the underlying mechanisms of a receptive music-based intervention (music listening) on alleviating apathy, with a focus on observing functional connectivity between the reward and auditory networks implicated in musical reward processing.
Silke Appel- CresswellNeurology2023
MRIOLERO (Roche/MN43964) study -A Multi-center, Single-arm, Open-label, Extension, Rollover Study to Evaluate the Long-term Safety and Efficacy of Ocrelizumab in Patients with Multiple Sclerosis.

Study MN43964 (Olero) is a single-arm, open-label extension (OLE), rollover study of ocrelizumab that allows for participants in Parent studies to continue treatment with ocrelizumab and thereby, aims at the continuation of collecting long-term safety and efficacy data.
Robert CarruthersMS & NMO Clinical Trials Group2023
MRI, FLAIR, rs-fMRI, DTI“A Placebo-Controlled Efficacy in iNPH Shunting (PENS) Trial” - Adult Hydrocephalus Study.

Idiopathic Normal Pressure Hydrocephalus is a condition of over- accumulation of cerebrospinal fluid (CSF) commonly seen in the elderly and of unknown cause, with current treatment paradigms involving surgical interventions such as shunting the CSF from the ventricles in the brain to the peritoneum in the abdomen. The current literature surrounding INPH has been insufficient and there remains a need for a placebo controlled study. The Placebo-Controlled Effectiveness in INPH Shunting (PENS) trial is a multi-centre blinded, randomized, placebo-controlled design investigation of CSF shunt surgery.
Thomas ZwimpferNeurosurgery2023
MRI, FLAIR, DTI, rs-fMRI, tb-fMRI, Single EchoModulating interhemispheric inhibition after stroke.

The aim of this work is to identify biomarkers to predict who will respond to interventions involving inhibitory brain stimulation after stroke, and generate new knowledge related to our understanding of the mechanisms of inhibitory brain stimulation. While inhibitory brain stimulation shows promise in promoting recovery after stroke when paired with motor practice, its response is variable: we do not know how stroke-related factors influence its subsequent impact on motor-related brain activity. By employing task-based functional magnetic resonance imaging pre and post stimulation, the current study will examine the impact of inhibitory brain stimulation on motor-related brain activity after stroke.
Lara BoydPhysical Therapy2023
MRI, FLAIR, SWI, DWIUX701-CL301. A Randomized, Double-blind, Placebo-controlled, Multicenter, Seamless, Adaptive, Safety, Dose-finding, and Phase 3 Clinical Study of UX701 AAV-mediated Gene Transfer for the Treatment of Wilson Disease, Industry (Ultragenyx) Vladimir Marquez AzalgaraGastroenterology
MRI-PDFFMerck NASH MK-3655-001. A Phase 2b Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-3655 in Individuals with Pre-cirrhotic Nonalcoholic SteatohepatitisSaumya JayakumarGastroenterology2022
MRI, FLAIR, rs-fMRI, DTI, MWIIMPACT 360 for Healthy Agers.

The purpose of this study is to evaluate effects of a multimodal intervention in healthy older adults and elucidate mechanisms driving associated changes. Participants will take part in a 6 month intervention involving exercise, mindfulness, and nutrition. The comprehensive assessment will focus on: cognition, inflammation, microbiome diversity, sleep quality, neurological imaging markers, fitness, cardiovascular health, and well-being. This assessment will: 1) Help us understand the mechanisms behind the benefits of this intervention and any interactive effects and 2) to serve as a normative dataset for replication in clinical populations.
Silke Appel- CresswellNeurology2022
MRI, FLAIR, rs-fMRI, DWI, MWI, SWICanadian Longitudinal Study on Aging (CLSA): Follow-up 3, Healthy Brains and Healthy Aging Initiative.

The CLSA Healthy Brains, Healthy Aging Initiative is a six-year study, funded by the Weston Family Foundation, that will create new datasets to enhance the CLSA database and facilitate independent research into the link between lifestyle, the human microbiome, and brain health. The study will involve 6,000 research participants enrolled in the CLSA, including more than 2,500 who will undergo magnetic resonance imaging (MRI) to monitor brain structure and function as they age. The resulting standardized datasets will be available for use by approved public-sector researchers in Canada and internationally.
Teresa Liu-AmbrosePhysical Therapy2022
MRI, FLAIR, DWI, QRM, SWIColchicine for the Prevention of Vascular Events after an Acute Intracerebral Hemorrhage (CoVasc-ICH) – Optional MRI Sub-study.

CoVasc-ICH Optional MRI Sub-Study enrolls interested participants from the main CoVasc-ICH study. This sub-study will try to determine the effects of colchicine on perihematomal edema formation and remote diffusion weighted imaging lesions on MRI.
Thalia FieldVancouver Stroke Program2022
MRI, rs-fMRI, fMRI, MWI, SWI, DTIMechanisms of non-invasive brain stimulation as a treatment option for patients with Parkinson's (All-Dressed).

In this study, Parkinson’s Disease subjects perform a simple motor task, while they receive subthreshold Electrical Vestibular Stimulation (EVS), and we simultaneously record motor vigour, fMRI and EEG. Different “calibration” stimuli will be delivered in the scanner, and the resultant recordings will be used to train a model to predict vigour from an arbitrary set of stimulation parameters. Precision designed EVS will be later tested outside of the scanner to see if this results in clinically-relevant enhancements in motor task performance.
Martin McKeownNeurology2022
MRI, ASL, DWI, DTI, SWI, MWI(ACQUIRE) Feasibility of multi-domain data acquisition in patients at risk for hypoxic-ischemic brain injury following cardiac arrest: a cohort study.

The ACQUIRE study designed to assess the feasibility data collection in multiple domains (Cerebral Blood Flow using transcranial Doppler, biomarkers of neurologic injury, electroencephalography and neuroimaging). In addition, we are seeking to determine the feasibility of clinical outcome assessment and neuroimaging at 6-months.
Don Griesdale (with Will Panenka)Dept. of Medicine, Anaesthesiology2022
MRI, FLAIR, ASL, rs-fMRI, DTI, SWI FCD - Memory after Concussion 2.0.

This study aims to advance our understanding of why memory problems often persist after concussion, after the brain has seemingly healed. We will be collecting MRI data to confirm that memory complaints after concussion are not directly related to measures of traumatic brain pathology, including corpus callosum white matter integrity and microbleeds. Using resting state fMRI, we will also investigate functional connectivity between the salience network and memory system in the brain in individuals with memory complaints after concussion and those without such complaints to determine whether differences between groups are observable at the level of brain function.
Noah SilverbergPsychology2022
MRI, FLAIR, DTI (MDD), Spectro - single voxel, QRM (MWI)Prediction of Cognitive and Motor Symptom Progression in Multiple Sclerosis Using Myelin Imaging. A.K.A: Longitudinal Observation of Brain and Spinal cord T2 Relaxation – Brief Interlude Subsequent Quantitative Evaluation (LOBSTR BISQUE).

In this study, we will ask our previous volunteers with MS to return 4 years after their original visit so we can collect additional physical, cognitive and myelin MRI data. We will explore whether the amount of myelin at the beginning of the study can predict changes in disability. We will also use new MRI tools to determine what other biological changes, in addition to myelin damage, are linked to progression. Understanding the link between biological changes (in particular myelin) and physical and cognitive changes will allow these more specific imaging methods to be used in clinical trials trying to slow myelin damage and progression.
Shannon KolindMS & NMO Clinical Trials Group2022
MRI, FLAIR Novel optimized ultrashort echo time multiband hydrogen pulse sequencesRadiofrequency Pulse and Pulse Sequence Design for Accelerated Sodium Magnetic Resonance Imaging.

While MRI excels at for detailed images of soft tissue lesions, including those due to traumatic brain injury, it difficult to use MRI to characterize damage to the bone. Ultrashort echo time (UTE) pulse sequences enable the acquisition of signal from tissues with short T2 relaxation time, but they overall scan times tend to be very long due to inefficiencies elsewhere in the sequence. This work aims to develop novel, optimized RF pulse sequences by employing novel MB prepulses.
Rebecca FeldmanPhysics & Astronomy2022
MRIA randomized, open-label, parallel-group, 18-month Phase 3 study to evaluate the effect of venglustat compared with usual standard of care on left ventricular mass index in participants with Fabry disease and left ventricular hypertrophy” Sanofi EFC16158 CARAT.Anna LehmanAdult metabolic Diseases Clinic2022
F. Hoffmann-La Roche - FENTREPID (GN41791) study - - Site 327128. NeuroRx Research. A Phase III Multicenter, Randomized, Double Blind, Double Dummy, Parallel Group Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared with Ocrelizumab in Adult Patients with Primary Progressive Multiple Sclerosis.

A study to evaluate the efficacy and safety of fenebrutinib on disability progression in adult participants with Primary Progressive Multiple Sclerosis (PPMS). All eligible participants will be randomly assigned to either daily oral fenebrutinib (or placebo) or intravenous (IV) ocrelizumab (or placebo).
Robert CarruthersMS & NMO Clinical Trials Group2022
MRI, 3 PLANEA randomized, open label, multi-center, active-comparator study to assess the efficacy, safety and tolerability of ofatumumab 20mg sc monthly versus continued current therapy in relapsing-remitting multiple sclerosis after elevation of serum neurofilament light levels (SOSTOS). Novartis

This study will evaluate if relapsing-remitting MS patients that have not had a relapse in the past year would benefit from a switch to ofatumumab versus staying on their continued current therapy. This study will also look at whether an elevated serum neurofilament light (NfL) level predicts enhanced benefit from a switch to ofatumumab.
Alice SchabasMS & NMO Clinical Trials Group2022
MRI, DTI, ihMTAdvanced MRI techniques to measure spinal cord microstructure in vivo: development and reproducibility.   

This study involves testing advanced MRI techniques (myelin water imaging, inhomogeneous magnetization transfer and diffusion imaging) to measure changes in the spinal cord after spinal cord injury. In this first stage we will optimize these techniques for spinal cord scanning on our 3T scanner and determine reproducibility for white and grey matter regions of interest.
Corree LauleICORD/ MRI Research Centre2022
MRIA Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study with Open-Label Extension to Evaluate the Safety. Tolerability, Pharmacokinetics and Pharmacodynamics of LMI070/branaplam when Administered as Weekly Oral Doses in Participants with Early Manifest Huntington's Disease.Blair LeavittCentre for Huntington Disease2022
A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, 76-Week Study Evaluating the Safety and Efficacy of Two Doses of Simufilam in Subjects with Mild-to Moderate Alzheimer’s Disease.

This study will investigate the safety and effectiveness of simufilam with those in placebo, in participants who are diagnosed with mild to moderate Alzheimer disease.

Simufilam is an oral drug meant to restore the normal shape and function of a brain protein called filamin A (FLNA). In patients with Alzheimer disease, the shape of FLNA is distorted. This triggers toxic signaling beta amyloid, and ultimately results in brain cell degeneration and inflammation.
Robin HsiungNeurology2022
MRI, DWI, DTI, FLAIR, rs-fMRI, ASLRoche WN42444 study: A Phase III, Multicenter, Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of Gantenerumab In Participants At Risk For Or At The Earliest Stages Of Alzheimer’s Disease.

People who have elevated brain amyloid levels may be at risk for or at the earliest stages of Alzheimer’s disease because they have signs of one of two core pathologies of Alzheimer’s disease (abeta amyloid or herein simply “amyloid”), although they do not have symptoms.

The purpose of Study WN42444 is to compare the effects, good or bad, of gantenerumab with those of placebo in participants who are cognitively unimpaired and have elevated levels of amyloid protein in the brain.

Gantenerumab is a man-made antibody that attaches to amyloid in the brain and mobilizes the immune system to remove it.
Robin HsiungNeurology2022
MRI, tb-fMRI
Transfer of Valence - fMRI equipment testing.

Prior work suggests that emotion not only alters memory for emotional content per se but can also alter memory for and attitudes towards associated experiences, a process known as transfer of valence. The neural correlates of these effects, however, have yet to be thoroughly investigated. To help us gain a better understanding of how emotion affects transfer of valence, we will ask participants to study pairs of images: one object (always neutral) and one scene (negative or neutral). We will then have participants complete a test phase where they will rate the pleasantness of the neutral objects followed by a memory task to determine memory for the pairings in each condition (negative vs. neutral).
Daniela PalomboPsychology2022
3-point Dixon; Proton spectroscopySexual dimorphism in physiological and bioenergetic responses to aerobic exercise.

Physical activity is a necessity for healthy living and dependent on the delivery of oxygen to the working muscles to generate energy. Our understanding of the body’s response to physical activity has primarily been characterized using the “typical 70-kg man”, yet substantial sex-differences in the lungs, heart, blood vessels, blood, and muscle may lead men and women to use different mechanisms to deliver oxygen and produce energy during activity. Our study will investigate these differences with a focus on various muscle characteristics including quantity, structure, fibre type, and respiratory capacity.
Robert BoushelKinesiology/ Fac. Of Education2022
MRI, DTI, rs-fMRILeft intermittent Theta Burst Stimulation vs. Right Low Frequency Repetitive Transcranial Magnetic Stimulation Effectiveness in Depression and Suicidal Ideation: A Randomized Non-Inferiority Trial (Left vs. Right Non-Inferiority Trial - LeRNIT).

MDD poses a great economic burden on the health care system due to its long-term disability with a low ability to participate in everyday activities. We aim to understand the mechanism of action of rTMS in clinical practice, improve the targeting of this treatment avenue using functional MRI scans, and investigate novel markers, such as heart rate variability, as an indication of treatment response. https://ninet.med.ubc.ca/research/
Fidel Vila-RodriguezPsychiatry2021
MRI, MWF, FLAIRVISIONARY-MS: A Phase 2, Randomized, Double-Blind, Parallel Group, Placebo Controlled Study for the Treatment of Visual Pathway Deficits In Chronic Optic Neuropathy to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of CNM-Au8 For Remyelination In Stable Relapsing Multiple Sclerosis (RMS). CLENE Nanomedicine, SNAC-Sydney Neuroimaging Analysis Centre.Tony TraboulseeMS & NMO Clinical Trials Group2021
MRI, DWI, STIREvaluation the role of transcervical 3D Ultrasound imaging of the oropharynx during transoral robotic surgery - TORS.

Transoral robotic surgery has the potential to provide better surgery outcome to patients with early-stage oropharyngeal SCC, and advances in image guidance during this procedure can optimize resection margins, as well as reduce the risk of complications such as neurovascular injury. The objective of our study is to assess the utility of using 3D transcervical ultrasound to assess oropharyngeal anatomy and pathology and the feasibility of ultrasound-MRI registration for intraoperative image guidance.
Eitan Prisman & Tim SalcudeanSurgery + Electrical & Computer Engineering2021
MRI, rs-fMRI, tb-fMRIFunctional role of eye movements during motor sequence learning
(Short title: Sensorimotor imaging & learning [SMiLE]).

The sensorimotor imaging & learning (SMiLE) study will evaluate how oculomotor control contributes to implicit motor sequence learning in healthy, young and older adults. Participants will practice a novel skilled reaching task for 3 days and undergo structural and functional magnetic resonance imaging before and after training. We will investigate change in brain connectivity associated with motor sequence learning. Our findings will contribute to better understanding of the underlying mechanisms contributing to skill learning in healthy adults.
Lara BoydPhysical Therapy2021
MRI, rs-fMRITechnical development time to test new MR-Rapid open bird-cage MR coil for concurrent TMS-MRI applications in phantomsFidel Vila-RodriguezPsychiatry2021
MRI, DWI, FLAIRLIBERTO- Single arm, open label multicenter extension study to evaluate the effectiveness and safety of Ocrelizumab in patients with multiple sclerosis previously enrolled in a F. Hoffmann-La Roche sponsored Ocrelizumab phase IIIb/IV clinical trial. Robert CarruthersMS & NMO Clinical Trials Group2021
MRI, tb-fMRI
Emotional Localization.

We want to investigate how emotional distractions around us can influence how we see and interact with other non-emotional objects arounds us. Specifically, we want to understand information presented to different senses (e.g., vision, audition) impacts our spatial awareness of the environment. We will utilize specialized behavioral tasks and powerful MRI scanners to help us uncover the underlying patterns of brain activity that guides our attention and action when we are emotionally stimulated.
Rebecca Todd
MRI, rs-fMRI, fMRI
Adapt and Avoid – fMRI.

Altered patterns of avoidance behaviours – which entail taking or withholding action to prevent unpleasant outcomes – are a feature of anxiety and depression; however, we only have a limited understanding of the neural circuits that underpin these behaviours. To address this gap in the literature, we adapt an rodent-based investigation of the neural correlates of avoidance behaviours into a human context (in which participants must learn which stimuli are associated with the need to make or withhold a series of button presses in order to avoid an unpleasant outcome). In particular, we focus on the neural representations of stimuli that signal the appropriate avoidance response to be made and the aversive or neutral outcome of the response to these stimuli.
Rebecca ToddPsychology2021
MRI, rs-fMRI, tb-fMRICannabis and Polysubstance Use: Imaging Response Inhibition and Stress Exposure (CAPU RISE).

Most stimulant users also use cannabis. The majority of cannabis users report stress reduction and coping motives for their use; however, there remains little biological evidence of cannabis reducing acute stress. This randomized control clinical drug trial employs a range of methods including biosampling, self-reports, actigraphy, and neuroimaging to examine the effects of cannabinoids on stress response, inhibition, and sleep in cannabis and stimulant co-users.
Christian SchützPsychiatry2021
MRE, MRI-PDFFThe Sonic Incytes Liver Incyte System, evaluation of liver fibrosis and steatosis versus MRE and MRI PDFF. SI-CLIN-02.

This study aims to evaluate the correlation of liver elasticity measurements between an investigational ultrasound-based measurement device (Liver Incyte System, manufactured by Sonic Incytes), the standard of care (FibroScan) as well as the non-invasive gold standard (MRE). In addition, this project aims to evaluate the discriminatory ability and investigate cut-offs for different stages of liver disease progression of the Liver Incytes System.

Alnoor RamjiGastroenterology, GI Research Institute2021
MRE, MRI-PDFFA Phase 2b Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (Merck NASH).
Alnoor RamjiGastroenterology, GI Research Institute2021
MRI, rs-fMRI, fMRIIndividualized pathways to recovery after stroke.

Pairing brain stimulation with rehabilitation after stroke is a promising approach. However, early studies of this intervention responses proved to be highly variable. Some people
showed a strong benefit while others did not. The main aim of the proposed program of research is to identify biomarkers that can be used to predict response to brain stimulation interventions.

Lara BoydPhysical Therapy2021
MRI, MRS, MRS in healthy participants: Neurochemical Atlas.

This study involves creating a metabolic map of the cingulate gyrus using optimized MRS parameters (sLASER, TR/TE=5000/32ms). We will examine the link between each voxel’s glutamate concentration and pain sensitivity (i.e., pain thresholds and laser evoked potentials). Further, the spatial distribution and variability of all metabolic concentrations will be examined.
John Kramer, Erin MacMillanICORD2021
MRI, rs-fMRITechnical proposal for testing real-time motion detection/ correction patchFidel Vila-Rodriguez, Erin MacMillanNon-Invasive Neurostimulation Therapies Lab (NINET) / MRI Research Centre2021
MRI, rs-fMFI, DTI, QRM (MWI)A prospective and longitudinal investigation of concussive and subconcussive mild traumatic brain injury mechanisms in ice hockey.

This study aims to address the public health problem of concussions and subconcussive head impacts in contact sports such as ice hockey. Our investigation will examine the mechanisms of (sub)concussions on brain function changes with mechanical trauma occurred over multiple hockey seasons. Findings from the study will inform how accumulation of trauma leads to long-term health problems including depression and severe personality change.
Alex Rauscher, Lyndia WuMRI Research Centre, Mechanical Engineering2021
MRI, DWI, SWI, MWI, rs-fMRICanadian Longitudinal Study on Aging: Coronavirus Disease 2019 (CLSA: COVID) Study.

Canadian Longitudinal Study on Aging COVID-19 Study: This study will compare brain structure, connectivity, and risk of silent stroke in older persons who have a history or symptoms of COVID-19 compared to older people without a history or symptoms of COVID-19.
Teresa Liu-AmbrosePhysical Therapy, Canada Research Chair in Physical Activity, Mobility, and Cognitive Health2021
MRI, DWI, ASL"ANAVEX2- 73", A Phase 2b/3, Double-Blind, Randomized, Placebo-Controlled 48-week Safety and Efficacy trial of ANAVEX2-73 for the Treatment of Early Alzheimer’s Disease (AD).

This study will investigate the safety and effectiveness of ANAVEX2-73 in people diagnosed with early to mild Alzheimer disease.

Participants will be randomised to receive either high or low dose ANAVEX2-73 or placebo (33% chance) over a period of 48 weeks. The study drug may protect brain neurons (brain nerve cells) that are usually damaged in Alzheimer’s disease, which may enable ANAVEX2-73 to modify AD.

After the screening and baseline visit, participants will return to the Clinic every 3 months for assessments that include cognitive testing, sleep questionnaires, study partner interviews, occasional safety labs, urinalysis and ECG. Outcome measures include regular assessments of cognitive and functional abilities.
Robin HsiungNeurology2021
MRI, DWI, QRMs"EMBARK", Phase 3b Open-Label, Multicenter, Safety Study of BIIB037(aducanumab) in Subjects with Alzheimer’s disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205.

The Biogen EMBARK study is an open-label, longitudinal study of the investigational drug aducanumab. The aim of the study is to assess the long-term safety and efficacy of monthly infusions of aducanumab in patients with Alzheimer disease. The study includes magnetic resonance imaging (MRI), positron emission tomography (PET), electrocardiography (ECG), blood sampling, cerebral spinal fluid (CSF) sampling (optional), neuropsychological testing, and caregiver interviews to assess the effects and safety profile of aducanumab.
Robin HsiungNeurology2020
MRI, DTI, SWI, ASL, PerfusionTRIC-VSI. Trial of Remote Ischemic Conditioning in Vascular Cognitive Impairment.

People with mild vascular cognitive impairment are prone to having little strokes, which can cause changes in cognition over time. Currently there are no treatments for mild vascular cognitive impairment that are approved by Health Canada. This study investigates whether Remote Ischemic Conditioning (cutting off blood flow to a limb temporarily without causing tissue damage) can be implemented successfully by patients, and whether it will improve cognition, brain imaging and blood markers.
Thalia FieldNeurology2020
MRI, rs-fMRI, tb-fMRIModulating interhemispheric inhibition after stroke.

The aim of this work is to identify biomarkers to predict who will respond to interventions involving inhibitory brain stimulation after stroke, and generate new knowledge related to our understanding of the mechanisms of inhibitory brain stimulation. While inhibitory brain stimulation shows promise in promoting recovery after stroke when paired with motor practice, its response is variable: we do not know how stroke-related factors influence its subsequent impact on motor-related brain activity. By employing task-based functional magnetic resonance imaging pre and post stimulation, the current study will examine the impact of inhibitory brain stimulation on motor-related brain activity after stroke.
Lara Boyd / Sarah KraeutnerPhysical Therapy2020
MRSMRS Multisite B0 Drift Phantom Study.

Contribution of phantom MRS data to a multisite B0 drift study lead by researchers at Johns Hopkins University.
Erin MacMillanMRI Research Centre2020
MRI, DWI, QRM, MTNatural History of Mild Degenerative Cervical Myelopathy: an observational study.

This study will permit identification of the key clinical, radiological and serum biomarker related variables predicting clinical deterioration of degenerative cervical myelopathy (DCM) patients. Such knowledge will facilitate improvements in the treatment of DCM, allowing surgeons to provide personalized recommendations depending on expected clinical course.
Nicolas DeaICORD, Neurosurgery2020
MRI, SWICANARY- Clinical dAta, Natural language pRocessing and eYe tracking for dementia risk stratification.

Our study is attempting to explore the relationship that exists between eye movement patterns, speech patterns, and cognitive decline. This study compares the speech and eye-movements of people with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) to healthy volunteers, to see if there are patterns that can be used to detect Alzheimer’s disease early, and to monitor the progression of Alzheimer’s disease over time.

Link to our study: https://www.vchri.ca/research-study/clinical-data-and-natural-language-processing-early-detection-dementia-canary
Thalia FieldNeurology2020
MRI, rs-fMRIBurnout and Resilience among Medical Professionals during COVID-19.

Burnout in the medical field has long been recognized as a significant problem. Currently available strategies to reduce burnout and build resilience against it are of limited effectiveness and are highly variable in their outcomes. This research will inform the selection and further development of more effective strategies, by using functional magnetic resonance imaging (fMRI) to provide a strong neuroscientific basis for the selection process.
UBC Cognitive Neuroscience of Thought Laboratory: http://www.christofflab.ca/
Kalina ChristoffCentre for Brain Health2020
MREA Phase 2, randomized, double-blind, placebo-controlled, multicenter, multinational, dose-finding study to evaluate the efficacy and safety of CC-90001 compared with placebo, in subjects with non-alcoholic steatohepatitis (NASH) and Stage 3 or Stage 4 liver fibrosis.Eric YoshidaGastroenterology2020
rs-fMRI, Perfusion, MRI
ALLFTD: ARTFL-LEFFTDS Longitudinal Fronto-temporal Lobar Degeneration.

The study aims to evaluate sporadic (s-) and familial (f-) frontotemporal lobar degeneration (FTLD) patients and asymptomatic family members of f-FTLD patients, characterizing the cohorts longitudinally and informing clinical trial design. The study has two arms: a “longitudinal arm” involving a comprehensive assessment of clinical, functional, imaging, and biofluid data collection, and a “biofluid-focused arm” involving limited clinical data to accompany biospecimen collection.
Ian Mackenzie
Pathology & Laboratory Medicine
CATIS-ICAD, Combination Antithrombotic Treatment for prevention of recurrent Ischemic Stroke in IntraCranial Atherosclerotic Disease: Protocol for a Pilot randomized trial.Samuel Yip
Vancouver Stroke Program2020
MRIFH Achilles Tendon Longitudinal (FHATL) Study.

Our study aims to enhance our understanding of the impact of Familial Hypdercholesterolemia on tendon health; a highly under-researched area of significant clinical importance. With the use of non-invasive techniques, we aim to examine various determinants of tendon functional recovery in individuals with newly diagnosed Familial Hypdercholesterolemia. This information is fundamental in identifying if current Familial Hypdercholesterolemia treatments methods reverse the functional and structural effect of the lipid accumulation within the tendon.
Alexander ScottCentre for Hip Health & Mobility2020
MRI, fMRI , BOLD, Neural Recruitment During Spontaneous Thoughts.

People frequently experience thoughts which seem to ‘come out of nowhere’, however, the neural underpinnings of this common psychological happening are poorly understood. Using fMRI scanning, we will investigate neural activity in human brains before a thought reaches one’s awareness, once it reaches awareness, during its subsequent elaboration (as a stream of thought), and during its dissipation. Find out more about this research on our laboratory website: http://www.christofflab.ca/
Kalina ChristoffPsychology2020
MRI, SWI, FLAIRMyelin Water Imaging in NMDA Receptor Autoimmune Encephalitis – Pilot Study.

Autoimmune encephalitis (AIE) is a serious condition caused by misdirected immune response against the brain. Magnetic Resonance Imaging (MRI) is used for the detection of brain abnormalities in many neurological conditions but routine MRI studies are normal in the majority of AIE cases, despite the obvious widespread neurological dysfunction. We aim to determine if there is damage to myelin due to widespread inflammation using Myelin Water Imaging (MWI) in AIE patients and if these relate to abnormalities in cognitive testing, serum neurofilament light-chain levels (a blood biomarker of neuronal damage), and retinal measurements obtained by optical coherence tomography.
Tony TraboulseeMS & NMO Clinical Trials Group2020
MRI, fMRI, DTICAN-BIND Validation study- Intergrated Biological Markers for the Prediction of Treatment Response in Depression.

The purpose of our study is to learn about ‘biomarkers’ (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression. This study involves standard treatment for depression. Patients will be treated by a psychiatrist for 16 weeks with an antidepressant medication approved to treat depression. No placebos are being used.
Raymond LamPsychiatry2020
MRISEARCH - StrokE and vAscular Risk factors contributing to neuroCognitive decline in adult congenital Heart disease.

Adults with Congenital Heart Disease (ACHD) are at increased risk of clinical and silent infarcts as well as dementia. The SEARCH study will be the first prospective cohort study in ACHD patients evaluating silent cerebrovascular disease over time, and how this is associated with cognitive changes and other vascular risk factors. We will evaluate 400 ACHD patients in BC over 3 years using neuroimaging, cognitive testing, and other imaging and bloodwork to try to address these knowledge gaps.
Thalia FieldNeurology2020
MRI-PDFF, MREA Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (resmetirom) in Patients With Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation- Madrigal MG-3196-11.Eric YoshidaGastroenterology2019
MRI, MRI-PDFFThe Sonic Incytes Liver Incyte System, assessment of liver fibrosis and steatosis, SI-CLIN-01.

This study looks to compare the use and results of a new ultrasound based measurement device (Liver Incyte, manufactured by Sonic Incytes) to the standard of care (FibroScan) as well as the non-invasive gold standard (MRE). In addition we would like to compare the fat measurement ability of ultrasound attenuation coefficient compared to that of MRI-PDFF.
Eric YoshidaGastroenterology2019
MRILong-term extension safety and efficacy study of SAR442168 in participants with relapsing Multiple SclerosisTony TraboulseeMS & NMO Clinical Trials Group2019
MRIThe Longitudinal Course of Intracortical Myelination and Cognitive Function in Bipolar DisorderLakshmi YathamPsychiatry2019
MRI, rs-fMRI, MRSIOffsetting hippocampal degeneration in moderate to severe TBI.

This randomized control trial is assessing the feasibility and efficacy of an online 16-week intervention employing allocentric spatial navigation tasks to enhance learning and memory capacity and to improve structure and function of the hippocampus following a moderate-severe traumatic brain injury (m-sTBI). Participants will undergo an MR scan, blood collection, and an assessment of behavioural outcomes 7 months and 12 months following a m-sTBI. Participants in the treatment arm complete the online intervention between these time-points while the controls do not.
William PanenkaPsychiatry2019
MRI, tb-fMRI, MWFCortical Responses to Visual Triggers in Urgency Urinary Incontinence Demonstrated Through Functional Magnetic Resonance Imaging.Lynn StothersICORD2019
rs-fMRIRegional brain activation during different forms of response inhibition, comparing young healthy adults with individuals with Bipolar Disorder.

People living with bipolar disorder often have problems with controlling impulsivity. Using MRI, we will identify subcomponents of response inhibition, a specific form of impulsivity. After, participants will receive 3 rounds of Transcranial Magnetic Stimulation (TMS) to test whether or not we can use it to change impulsivity.
Christian SchützPsychiatry2019
MRI, rs-fMRIThe GBA multimodal studyJon StoesslNeurology, Pacific Parkinson Research Centre2019
MRI, MEDICHemorrhage within the spinal cord after acute traumatic injury - the relationship to hemodynamic management and thromboembolic prophylaxis.Brian KwonOrthopaedics, ICORD2019
MRILinking biomechanical and imaging outcomes to better understand the effects of running on knee joint health.

Running is a very popular activity for many adults. However, a diagnosis of knee osteoarthritis is often seen as a “death sentence” for someone’s recreational running career. This study will provide the first evidence to determine the safety of runners for people with degenerative cartilage due to osteoarthritis.

Michael HuntPhysical Therapy2019
MRI, DWIAXIOMATIC - A Global, Phase 2, Randomized, Double-Blind, Placebo- Controlled, Response-Adaptive Dose-Ranging Study of BMS-986177, an Oral Factor XIa Inhibitor, for the Prevention of New Ischemic Stroke or New Covert Brain Infarction in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA)
Philip Teal/ Thalia FieldNeurology2019
MRI, rs-fMRI, DTI, GRASEDoes Opera training sculpt the brain to learn? Study 1- Language Intensive.

Learning how to perform opera is both cognitively and physically demanding, yet some of the students who have been most successful in UBC’s Opera Program have had learning-related disabilities, and appear to have overcome their difficulties, or to have learned compensatory skills that help them not just in opera performance but beyond. The goal of the proposed research is to systematically evaluate and better explain the neural foundations of that observation. In this endeavor, a study is proposed to measure executive function and other learning capabilities before and after a month-long language intensive course that is a required component of UBC opera training, and to determine – through MRI measurement of anatomical changes in fiber tracts in the brain – the neural bases of any observed behavioral improvements.
Lara BoydPhysical Therapy2019
MRI, DWI, SWICanProCo – Canadian Proactive Cohort Study for People Living with Multiple Sclerosis.

Canadian Proactive Cohort Study for People Living with Multiple Sclerosis (CanProCo) is an observational study designed to better understand the factors that contribute to MS disease progression using tools from different fields such as epidemiology (i.e. number of patients and distribution of diseases), medical imaging, and immunology (blood). Subjects will participate in annual visits over a 5-year period.
Tony TraboulseeMS & NMO Clinical Trials Group2019
MRIA Phase 2B Dose-finding study for SAR442168, A Bruton's tyrosine kinase inhibitor, in participants with relapsing Multiple Sclerosis (Sanofi DRI15928)Tony TraboulseeMS & NMO Clinical Trials Group2019
MRIAn open-label, single-arm 4-year study to evaluate effectiveness and safety of Ocrelizumab treatment in patients with Progressive multiple sclerosis. (Roche Consonance- MN39159)Robert CarruthersMS & NMO Clinical Trials Group2019
MRI, MWI[Roche] Pilot study of PET (Positron Emission Tomography) Imaging: Correlations with Advanced MRI in MSRobert CarruthersMS & NMO Clinical Trials Group2019
MRIHOPE- Hip Osteoarthritis Progression Evaluation . Population-Based Longitudinal Cohort Study of Femoroacetabular Impingement of the Hip Using Magnetic Resonance Imaging Outcomes.
The goals of the study are to investigate whether radiographic FAI and physical activity are risk factors for progression of cartilage damage and other MRI outcomes over 7 years. This study includes a randomly selected population of young adults aged 20-49 with and without hip pain.
Jolanda CibereRheumatology2019
MRI, DWIAbbVie. A Phase 2 Multiple Dose, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABBV-8E12 in Subjects with Early Alzheimer´s Disease.

This is a 96-week Phase 2 clinical trial for people with mild cognitive impairment to mild Alzheimer disease. The study treatment, an anti-Tau agent, may be able to block soluble tau aggregates, and thereby decrease the spreading of tau pathology in brains with tauopathy. Patients who meet all of the inclusion criteria will receive monthly IV study treatment or placebo for the duration of their enrollment.
Ging-Yuek Robin HsiungNeurology2018
MRI, DTI, rs-fMRI Multi-Site, Prospective, Longitudinal, Cohort Study Measuring Cerebrospinal Fluid Mutant Huntington Protein in Patients with Huntington’s Disease.Blair LeavittMedical Genetics; Centre for Huntington Disease2018
fMRIA randomized, double-blinded, sham-controlled cross-over with open-label extension study of theta-burst stimulation transcranial magnetic stimulation in non-fluent/agrammatic variant primary progressive aphasia.Fidel Vila-RodriguezPsychiatry2018
MRI, DWI, ElastographyOptimizing the management of high-risk and unfavorable intermediate-risk disease: the use of advanced imaging, trans-perineal mapping biopsies, and dual-strength brachytherapy sources to minimize radiation dose to normal tissues [OPTiMAL]Michael PeacockBC Cancer Agency2018
MRIPET Studies of dopamine turnover and release in bipolar disorder: Montreal Imaging Stress task PET studyLakshmi YathamPsychiatry2018
MRI, MTRMAGNIFY: A 2-year Prospective Study to Evaluate the Onset of Action of Mavenclad® in Subjects with Highly Active Relapsing Multiple Sclerosis Robert CarruthersMS & NMO Clinical Trials Group2018
TMS-fMRITMS-fMRI - Treatment response in TRD with interleaved TMS-fMRIFidel Vila-RodriguezPsychiatry2018
MRI, MWITechnical development on the Ingenia Elition: MWI, QSM and FLAIR2Shannon Kolind, Alex Rauscher, Adam DvorakMRI2018
LEMCOG Healthy Controls - A prospective 24-month investigator sponsored trial to determine the course of cognitive function and how it relates to MRI measures of structural and functional connectivity in healthy controls across time.
Collection of non-Multiple Sclerosis (MS) untreated control data is invaluable for interpretation of data acquired in MS treatment trials on cognitive outcomes such as memory. Advanced MRI techniques detect differences in the brain between people with and without MS. Understanding differences in brain connection patterns in people without MS helps us to understand the biological changes that may lead to cognitive challenges in MS.
Shannon KolindNeurology2018
MRI; SWISMOOTH OPERATOR: Smooth Pursuit as a predictor of cerebral small vessel disease.
Cerebral small vessel disease (cSVD) is one of the most prevalent neurological disorders and can lead to problems such as dementia or stroke. However, cSVD is usually only discovered on neuroimaging after symptoms develop. We hope to explore the utility of basic bedside assessments (smooth pursuit eye movements and spontaneous speech patterns) as indicators of the presence and severity of underlying cSVD in pre-symptomatic patients.
Thalia Field
MRI; fMRIADNI 3: Alzheimer's Disease neuroimaging initiative 3Ging-Yuek Robin HsiungNeurology2018
MRI, fMRI, DWISIGNAL: A Phase 2, multi-center, randomized, double-blind, placebo controlled study in subjects with late prodromal and early manifest Huntington’s disease (HD) to assess the safety, tolerability, pharmacokinetics, and efficacy of VX15/2503.Lynn RaymondCentre for Huntington Disease2018
MRI, fMRI, DWIAerobic exercise and CogniTIVe functioning in women with breAsT cancer: the ACTIVATE trial.
This study examines the impact of an aerobic exercise intervention on chemotherapy-related cognitive changes (CRCC) in women diagnosed with breast cancer who undergo chemotherapy treatment. The results of this study aim to address the effect and timing of aerobic exercise on CRCC, as well as the outcome of exercise during or following treatment on global measures of brain structure, functioning, and organization through fMRI and EEG assessments.
Kristin CampbellPhysical Therapy2018
MRI, DTI, SWIMapping the medial forebrain bundle in chronic post-concussive syndrome.
We propose that injury to the medial forebrain bundle is the cause of the chronic
post-concussive syndrome (PCS). This is a proof of concept study involving a single
subject with PCS following a rotational head injury.
Trevor Hurwitz with Josue Avecillas- ChasinPsychiatry2018
MRI, rs-fMRI, DTI, SWI, DBSI, spectrosc.Susac Syndrome Advanced Characterization (SuSAC): A Multidisciplinary Assessment of the Disease including Advanced MRI, Ocular Coherence Tomography, and Neuropsychological Testing.
Susac Syndrome, a rare autoimmune disease often misdiagnosed as Multiple Sclerosis, and is a poorly understood disease with no proven treatments. This study will be the first to combine a multidisciplinary evaluation of clinical status and disease activity with advanced imaging metrics. The results will provide pilot data that may broaden our understanding of disease pathogenesis and allow important structural and functional relationships to emerge.
Robert CarruthersMS & NMO Clinical Trials Group2018
MRI, rs-fMRI, DTIFOXY- Phase 2 Clinical Trial of Intranasal Oxytocin for Frontotemporal Dementia - MRI Research Centre.
The purpose of this study is to evaluate the efficacy of intranasal oxytocin in reducing social apathy in participants with a diagnosis of Fronto-temporal dementia.
Robin HsiungNeurology2018
MRI, Perfusion, DiffusionWhen are blood vessels “ready to rupture”? Cerebrovascular health following spinal cord injury.
This study explores the cerebrovascular consequences of intermediate (i.e., 1-2 years) and chronic (i.e., >5 years) exposure to daily autonomic dysreflexia in humans with spinal cord injury. We are interested in finding out if the episodic hypertension associated with autonomic dysreflexia impacts cerebrovascular regulation, which plays a role in predisposing this population to cerebral small vessel disease, overt stroke and cognitive decline.
Dr. Andrei KrassioukovICORD2017
fMRIScene construction in spontaneous thought.
This study will look at the neural basis of the thought dynamics and contents; specifically, the difference between freely moving and deliberately constrained thought, both with and without imagery of spatially anchored scenes. To investigate this, we will combine fMRI and experience sampling.
Dr. Kalina Christoff (w/ Yvette Graveline)Psychology2017
MRI, rs-fMRINext steps for understanding the neuro-cognitive basis of physical activity adherence.
The current study will examine whether individual differences in neural activation using two fMRI experiments predicts future adherence to physical activity over a 6-month period among adults. The first experiment will examine neural responses to the engagement in inhibitory control. The second experiment will examine neural responses to observing health promotion messages related to physical activity and sedentary behavior.
Teresa Liu-AmbrosePhysical Therapy2017
rs-fMRI; MRI; DTI; SWINovel Retinal Biomarkers for Alzheimer's Disease.
Detecting the beginning of Alzheimer disease (AD) in the eye by using a noninvasive imaging device that can show amyloid in the retina. This study is an observational, non-treatment study to identify retinal biomarkers associated with AD, and the outcomes measures include 3T MRI, PiB-PET, 3D/2D Retinal Images, Retinal functional tests, and a variety of cognitive and behavioural interviews. The study will assess the efficacy of the device in rodent models and patients with AD, and if successful, the device may lead to better and earlier diagnosis of AD with lower cost.
Robin Hsiung / Prof. Mirza Faisal Beg (SFU)Neurology2017
MRIENSEMBLE: An Open-Label, Single-Arm Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Patients with Early Stage Relapsing Remitting Multiple SclerosisRobert CarruthersMS & NMO Clinical Trials Group2017
MRI; rs-fMRIAn Open-Label Extension Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ISIS 443139 in Huntington’s Disease Patients Who Participated in Prior Investigational Studies of ISIS 443139. ISIS 443139-CS2.Blair LeavittMedical Genetics; Centre for Huntington Disease2017
MRI; rs-fMRIReshaping the Path of Mild Cognitive Impairment by Refining
Exercise Prescription.
In this proposed study, we will study the effects of different types and combinations of exercise training on cognitive function in older adults who are at increased risk for dementia (i.e., mild cognitive impairment). Older adults with mild cognitive impairment represent an ideal target population for intervention strategies, as the preservation of their cognitive function will likely maintain and prolong their ability to live independently and with quality. Furthermore, we will explore how each exercise type improves cognitive function as such information may lead to new discoveries and therapies.
Teresa Liu-AmbrosePhysical Therapy2017
fMRIThought Dynamics (Spontaneous Thought).
This study will look at the neural basis of the dynamics of thought; particularly, the differences between freely-moving thought and constrained thought. To investigate this, we will combine experience sampling with fMRI.
Kalina ChristoffPsychology2017
MRISynchronizing Exercises, Remedies in Gait and Cognition (SYNERGIC) Trial.
A Randomized Controlled Double Blind Trial.
Physical exercises, cognitive training, and vitamin D are low cost interventions and have the potential to enhance cognitive and mobility function in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI). Currently, it is unclear whether aerobic, resistance, or tone and stretching exercise would have different effects on cognitive performance. We postulate that combined strength and aerobic training will have a better effect on cognition over tone stretching-control exercise in an MCI population. Additionally, we will assess if a multi-domain intervention including cognitive training and vitamin D will have synergistic efficacy.
Teresa Liu-AmbrosePhysical Therapy2017
MRIProstate evaluation for clinically important: MRI vs. standard evaluation procedures (PRECISE). Peter Black (Silvia Chang)Prostate Centre2017
MRIDevelopment of Magnetic Resonance Elastography System for Liver ImagingTim SalcudeanElectrical and Computer Engineering2017
MRITesting Inhomogeneous Magnetization Transfer (TIHMT). Inhomogeneous Magnetization Transfer (ihMT) is a new imaging technique that shows promise for myelin selectivity, which could lead to better detection and treatment of demyelinating diseases such as Multiple Sclerosis. This study will compare ihMT to myelin water fraction images, and assess the two techniques’ selectivity to myelin.Alex MacKayPhysics & Astronomy
MRSImplementing GABA editing MRS capacity at UBC Fidel Vila-RodriguezPsychiatry2017
MRI, MRSMEDDAY- effect of MD1003 in progressive Multiple Sclerosis: A randomized double blind placebo controlled studyVirginia DevonshireNeurology2017
MRI; rs-fMRILEM-COG: A Prospective 24-Month Observational Study to Evaluate Neurocognitive Function and Safety in Patients with Relapsing Multiple Sclerosis Who Are Initiating LEMTRADA® Treatment in Routine Clinical PracticeAnthony TraboulseeNeurology2017
MRILOBSTr: establishing an imaging biomarker for disease progression in multiple sclerosis. MS is a disabling neurological disease with a highly variable clinical course including acute disability (relapses when symptoms appear or worsen) and disease progression (steady accumulation of disability in the absence of relapses). There is currently no approved treatment for progressive MS. A principal pathology of MS is the destruction of myelin, which surrounds nerves to speed up signal conduction. We have developed a magnetic resonance imaging technique that provides quantitative measurements of myelin. Our aim is to establish myelin water imaging as a biomarker for disease progression, allowing efficient clinical trials to establish effective treatment options for progressive MS.Shannon KolindNeurology2017
MRICOMB ofatumumab versus teriflunomide in patients with relapsing MSRobert CarruthersMS & NMO Clinical Trials Group2017
MRIMRI Actuator Evaluation/Liver MRE in Healthy VolunteersTim SalcudeanElectrical and Computer Engineering2017
MRISubject-specific Mastication Modeling and its applications in Reconstructive SurgerySidney FELS (Amir Abdi)Electrical and Computer Engineering2017
MRIParotid functional mapping using chemical exchange saturation transfer (CEST)Nevin McVicar / Steven ThomasMedical Physics2017
fMRIEXML – Effect of aerobic exercise on neuroplasticity and motor learning post strokeLara BoydPhysical Therapy2017
MRSGlutamate as a biomarker of pain intensity in the anterior cingulate cortexJohn Kramer / Corree LauleBlussal Spinal Cord Centre / ICORD2017
MRIThe effects of running on knee cartilage measures in people with and without knee osteoarthritis. A pilot studyMichael HuntPhysical Therapy
MRIPilot Study of PET Imaging: Correlation with Advanced MRI inMSRobert CarruthersNeurology2017
MRIAdvanced MRI measures of normal appearing white matter in progressive solitary sclerosis compared to primary progressive MS, relapsing-remitting MS, and healthy controlsRobert Carruthers / Shannon KolindNeurology2017
MRIPilot Study for Myelin Water Imaging in Cervical Spinal CordShannon KolindNeurology2016
MRIBiomarker Study to Explore Mechanism of Action of Ocrelizumab and B-cell Biology in MS (OBOE Study)Robert CarruthersMS & NMO Clinical Trials Group2016
fMRIMRI of Cerebrovascular ReactivityAlex RauscherPaediatrics2016
fMRICanadian rTMS Treatment and Biomarker Network in Depression (CARTBIND) TrialFidel Vila-RodriguezPsychiatry2016
fMRIMagnetic Resonance Imaging Biomarkers in Amyotrophic Lateral SclerosisSanjay Kalra and Hannah BriembergNeurology2016
fMRIRandomized double-blind sham-controlled trial of repetitive transcranial magnetic stimulation (rTMS) for bipolar depressionLakshmi YathamPsychiatry2016
MRIPhase III, multicentre, randomized, double-blind, placebo-controlled, parallel-Group, efficacy, and safety study of Crenezumab in patients with prodromal to mild Alzheimer's disease (ABBY 3 Study)Ging-Yuek Robin HsiungNeurology2016
MRIDetection of metastatic brain tumours using dynamic glucose enhanced MRI after D-Glucose injectionNevin McVicarBCCA2016
MRIAdvanced Quantitative Imaging in Cervical Spinal CordShannon KolindNeurology2016
fMRIA Medium Chain Triglyceride INTervention for Alzheimer Disease (A MINT for AD) Phase I Study (MINT-01)Haakon NygaardNeurology2016
fMRICanadian Consortium for Neurodegeneration in Aging (CCNA): The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) StudyGing-Yuek Robin HsiungNeurology2016
fMRIThe SARTAN-AD Trial: A randomized, open label, proof of concept study of Telmisartan vs. Perindopril in hypertensive mild-moderate Alzheimer's disease patientsGing-Yuek Robin HsiungNeurology2016
fMRIThe ENGAGE Study: A Phase 3 Multicenter, Randomized, Double-Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer's DiseaseGing-Yuek Robin HsiungNeurology2016
fMRIA novel approach to studying postural instability in Parkinson's disease using functional Magnetic Resonance Imaging (fMRI)Mark CarpenterKinesiology2016
MRIImportance of diffusely abnormal white matter on disability and progession in MSCornelia LauleRadiology2016
MRIVACCINE StudyTony TraboulseeMS Clinical Research2015
fMRINeurobiological Correlates of TMS in NHPDoris DoudetNeurology2015
MRIARPEGGIO StudyRobert CarruthersMS Clinical Research2015
fMRIArrowsmith and mTBINaznin Virji-BabulPhysical Therapy2015
MRITOPAZ extension studyTony TraboulseeMS Clinical Research2015
MRIMild traumatic brain injury genotyping and phenotyping with advanced imaging, Electroencephalography, and cognitive probes (MTBI)William PanenkaPsychiatry2015
MRIReshaping the Path of Vascular Cognitive Impairment with Resistance TrainingTeresa Liu-AmbrosePhysical Therapy2015
fMRIYohimbine Aging and Reproducibility StudyDoris DoudetNeurology2015
fMRIThe Integrated Neurostimulation Platform for Neuropsychiatric Research Group - Investigating predictors of treatment response in treatment-resistant depression (TRD) with interleaved TMS/fMRIFidel Vila-RodriguesPsychiatry2015
MRIThe AMARANTH Study: A 24-month, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Efficacy, Safety, Tolerability, Biomarker, and Pharmacokinetic Study of AZD3293 in Early Alzheimer's DiseaseGin-Yuek Robin HsiungNeurology2015
fMRIIdentifying the Neurocognitive Impairments Associated with Recurrent Falling Among Community-Dwelling SeniorsTeresa Liu-AmbrosePhysical Therapy2015
fMRIImproving physical activity using an online monitoring tool: a new model of care for knee osteoarthritisTeresa Liu-AmbrosePhysical Therapy2015
fMRIThe Effect of Fit Brains Training on Cognitive Performance in Older AdultsTeresa Liu-AmbrosePhysical Therapy2015
MRIA Double-masked, Placebo-controlled Study with Open-label Period to Evaluate the Efficacy and Safety of MEDI-551 in Adult Subjects with Neuromyelitis Optica and Neuromyelitis Optica Spectrum DisordersRobert CarruthersNeurology2015
MRIRelationship between cervical spinal cord microstructure, metabolite concentrations, and neuropathic pain after spinal cord injuryJohn KramerICORD2015
MRIISIS 443139-CSIBlair LeavittMedical Genetics2015
MRIFYN Study: A Phase 2a Multi-Center Study of 18F-FDG PET, Safety and Tolerability of AZD0530 in Mild Alzheimer's disease Haakon NygaardClinic for Alzheimer disease and Related Disorders2015
fMRIAssessment of “normal appearing” white matter in Parkinson's Disease and its association with cognitive dysfunctionAlex MacKayUBC MRI Research Centre2015
MRILongitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)Ian MackenziePathology2015
MRIAdvancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL)Ian MackenziePathology2015
fMRITreating Depression in Parkinson's Disease with Transcranial Direct Current StimulationJon StoesslNeurology2015
fMRIBlack Box Theatre of the MindPolly Gibbons/Ron BurnettEmily Carr University2015
fMRINeurological Networks Underlying Cognition in PsychosisTodd WoodwardPsychiatry2015
fMRIBrain Network InteractionsKalina ChristoffBrain Research Centre2015
MRIComparison of Aripiprazole vs Risperidone on Brain Morphology using MRI - The CARB studyAlasdair BarrPsychiatry2015
MRIFeasibility Study of MR Imaging on Parotid Gland Stimulation (SPIT) Stefan ReinsbergPhysics2015
MRITau and Neuroinflammation Imaging in Parkinson's disease and Related DisordersJon StoesslNeurology2015
fMRIMotor Planning Post-StrokeLara BoydPhysical Therapy2015
MRIPost Mortem Fetal MRIAlex Rauscher/Denise PugashPaediatrics2015
MRIImaging Tau Accumulation with PBBH3 in Healthy ControlsJon StoesslNeurology2014
fMRINeural corelates of autonomic regulation in elite athletes combining heart rate viariability with fMRILara BoydPhysical Therapy2014
fMRIcharactering the impact of silent lesions on stroke recovery using mulimodal neuroimagingLara BoydPhysical Therapy2014
MRIFeasibility of spectroscopy and DTI in non-human primates: Pilot study for CIHRDoris DoudetPacific Parkinson's Research Centre2014
fMRIArrowsmith Brain ImagingLara BoydPhysical Therapy2014
MRIThe Neural Correlates of delusions of reference and recovery from delusionsMahesh MenonPsychiatry2014
MRIEfficacy of B11B019, Declizumab High Yield Process (DAC-HYP), Monotherapy in subjects with re: An Investigator-Initiated, Multicentre, Phase IV, Open-Label Study to evaluate the biological basis for susceptibility or resistance to disease progression in relapsing-remitting multiple sclerosis patients treated in routine practice with Gilenya for 5 years (IGLOO)Tony TraboulseeMS Clinical Research2014
fMRIStructural and Functional Correlates of Neuroplastic Change Associated with StrokeLara BoydPhysical Therapy2014
MRIWhat is the relationship between hip musculature; knee joint alignment, pain and function in people with and without knee osteoarthritis?Karim KhanCentre for Hip Health and Mobility2014
fMRISensorimotor plasticity underlying the recovery of skilled walking in people with chronic incomplete SCITania Tam & Lara BoydPhysical Therapy2014
fMRICharacterizing the impact of silent lesions on stroke recovery using multimodal neuroimagingLara BoydPhysical Therapy2014
MRIAcoustic Noise Measurement o Noise from single-Shot EPIStefan ReinsbergPhysics & Astronomy2014
fMRIStructural and Functional Correlates of Neuroplastic Change Associated with StrokeLara BoydPhysical Therapy2014
MRIWhat is the relationship between hip musculature; knee joint alignment, pain and function in people with and without knee osteoarthritis?Karim KhanFamily Practice2014
MRIA randomized controlled study of conventional versus theta-burst repetitive transcranial magnetic stimulation in the treatment of major depressive disorderFidel Vila-RodriguezPsychiatry2014
MREMagnetic Resonance Elastography of the liverTim SalcudeanElectrical Engineering2014
MRIComparative study 0.5T MR Open versus 3.0T MRI - Region of interest: kneeDavid HartCentre for Hip Health and Mobility2014
MRIDevelopment of new MRI Techniques for NeuroimagingAlex RauscherRadiology2014
MRIMedical Imaging Trial Network of Canada (MINTEC) Protocol C6: Amyloid and glucose PET Imaging in Alzheimer and Vascular Cognitive Impairment patients with significant White Matter DiseaseGing-Yuek Robin HsiungNeurology2014
MRIThe Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease Study - A4Ging-Yuek Robin HsiungNeurology2014
MRIA multi-centre, randomized, double-blind, placebo-controlled, phase 3 study to evaluate the efficacy and safety of SA237 as monotherapy in patients with neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) Chugai Pharmaceuticals Protocol #: SA-309JGTony TraboulseeMS Clinical Trials2014
fMRICharacterizing the Functional Contribution of White Matter Systems within Distributed Neural NetworksRyan D'ArcySFU2014
MRIPhase I/II Interventional Clinical Trial of Balloon Venoplasty for Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis (CCSVI)Tony TraboulseeNeurology2013
MRSIn Vivo 31P-MR spectroscopy for evaluation of mutation load in a family with MELAS (Mitochontrail Myopathy Encephalopathy, Lactic Acidosis and Stroke like episodesGabriella HorvathAdult Metabolic Diseases Clinic2013
MRIA phase-II randomized, double blind, parallel group, placebo-controlled, multi-centre study to evaluate the safety and efficacy of Abatacept in adults with relapsing-remitting Multiple SclerosisJoel OgerNeurology2013
fMRISensorimotor plasticity underlying the recovery of skilled walkin in people with chronic incomplete spinal cord injuryTania Lam/Lara BoydPhysical Therapy2013
fMRIPBR28 in healthy controls: serotonergic innervation and Levodopa-derived Dopamine release in PD: an in vivo PET studyVesna SossiPacific Parkinson's Reasearch Centre2013
fMRIExercise in Parkinson's DiseaseJon StoesslPacific Parkinson's Reasearch Centre2013
MRIMyelin Maps ofr T1 and T2 Weighted Scans?Alex RauscherRadiology2013
fMRINeural Basis of Spontneous ThoughtKalina ChristoffBrain Research Centre2013
fMRIRegional Brain Activiation during different forms of response inhibition comparing young health adults with problem stimulant users and problem gambersChristian SchutzPsychiatry2013
MRICortical inhibition in unipolar and bipolar depression compared to healthy subjects: a TMS-EEG studyLakshmi YathamPsychiatry2013
MREFTPC: Focal Therapy for Prostate Cancer: A study using focal low dose rate brachytherapy as an alternative to active surveillance and radical treatment forfavourabe risk prostate cancerJames MorrisBC Cancer Agency2013
MRIComparative study 0.5T Open MR vs 3.0T MRI: Region of interest - KneeDavid HartCentre for Hip Health and Mobility2013
MRICharacterization of Dementia due to Mixed Alzheimer and subcortical vascular pathologyRobin HsiungNeurology2013
fMRIIs there a homunculus in the visual cortex?Jason BartonOphthalmology2013
MRISerial comparisons of abdominal and neurological MRI scans of patients with refractory pychosis disorders (SCAN MRI)Alasdair BarrPsychiatry2013
MRIDIAN-TU-001: a phase II/III randomized, double-blind, placebo-controled multi-centre study of 2 potential disease modifying therapies in individuals at risk for and with dominantly inherited Alzheimer's diseaseRobin HsiungNeurology2013
MRIT2 relaxometry MRI for the diagnosis of prostate cancerPiotr KozlowskiUBC MRI Research Centre2013
MRIDevelopment of a new imaging technique of knee cartilage in osteoarthritisAlex RauscherRadiology2013
fMRIExercise-induced and music-induced brain connectivity changes in Parkinson's DiseaseMartin McKeownNeurology2013
MRITractography after bilateral anterior capsulotomyAndrew HowardPsychiatry2013
fMRINeural correlates of autonomic regulation in elite athletes combining heart rate variability with fMRILara BoydPhysical Therapy2013
MRITRACK-ONBlair LeavittNeurology2012
MRIComplications of Parkinson's Disease: The Dopamnergic Basis of Depression; Study 1Jon StoesslNeurology2012
MRIIMPAKT-Hip: Natural History of FAI StudyJolanda CibereOrthopaedics2012
fMRIEffects of Exposure to Air Pollution on Congitive Function (EAPOC)Christopher CarlstenRespiratory Medicine2012
fMRIAssessment of Cerebrovascular function using MRI and Blood Gas ManipulationWilliam SheelHuman Kinetics2012
MRIStudy of Myelination in Multiple Sclerosis using MRI and MEPsTony TraboulseeNeurology2012
MRIPseudo-atrophy of the brain in Multiple Sclerosis (Extension)Tony TraboulseeNeurology2012
fMRICognitive characterization of Individuals Genetically At-Risk for Frontotemporal DementiaClaudia JacovaNeurology2012
MRIMITIGATE-HDBlair LeavittNeurology2012
FfMRIIntegrated biological markers for the prediction of treatment response in depressionRaymond LamPsychiatry2012
MRIA Phase II, multicentre, randomized, parallel-group, partially blinded, placebo and Avonex controlled dose finding study to evaluate the efficacy as measured by brain MRI lesions, and safety oftwo does regimens of ocrelizumab in patients with relapsing-remitting multiple sclerosis ROCHE WA21493C/CAT4422gLorne KastrukoffNeurology2012
MRIA PET study of NE Transporter Occupancy and Symptom Response in Depressed Patients Treated with Quetiapine XRLakshmi YathamNeurology2012
fMRIClinical and neural funcitoning outcomes following group-based family cognitive-behaviour therapy in pediatric obsessive-compulsive disorder (OCD)Evelyn StewartPaediatrics2012
MRIThe Relationship Between Serotonergic Innervation and Levodopa-Derived Dopamine Release in Parkinson's disease: an in vivo PET StudyJon StoesslNeurology2012
MRIAdvanced MRI Measures of Repair in Ocrelizumab treated PatientsTony TraboulseeNeurology2012
rs-fMRIEffects of Brain Magnesium concentration on 31P-MRS and resting state fMRI in ParkinsonÕs diseaseMartin McKeownNeurology2012
fMRIBrain Activation during Motor Tasks after SCIJanice EngPhysical Therapy2012
fMRICortical and Subcortical Effects of Galvanic Vestibular Stimulation in Parkinson's DiseaseMartin McKeownNeurology2012
MRIAnatomical and functional MRI Correlates of Cognitive Dysfunction in Multiple SclerosisAlex MacKayPhysics & Astronomy2012
fMRINeural and Biochemical Correlates of Inner Time Consciousness in Professional SwimmersGeorg NorthoffPsychiatry2012
MRIThe Evolution of Parkinson's DiseaseJon StoesslNeurology2012
MRSA Longitudinal Comparison of Aripiprazole vs. Higher Metabolic Risk Antipsychotic Drugs on Adiposity Using MRI (CALM study)Alasdair BarrPsychiatry2012
fMRICan exercise improve cancer associated cognitive dysfunctionKristin CampbellPhysical Therapy2011
MRIA multi-centre, randomized, double-blind, placebo-controlled, parallel-group, phase II trial to investigate the efficacy and safety of weekly intra-articular (i.a.) injections of 10, 30, and 100 _g of AS902330 for three consecutive weeks in patients with acute cartilage injury of the kneeDavid LiRadiology2011
MRIBaminercept: A Multicentre, Randomized, Blinded, Placebo-Controlled, Dose-Escalation Study to Evaluate the Penetration and Pharmacodynamic Effects of Baminercept in the CSF and Safety in Subjects with Secondary Progressive Multiple SclerosisTony TraboulseeNeurology2011
MRIControlled High Risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurological Surveillance: CHAMPIONS Continuation StudyTony TraboulseeNeurology2011
MRIInterhemispheric contributions to neuroplasticity and motor learning after strokeLara BoydRehabilitation Sciences2011
fMRIA double-blind, randomized, placebo-controlled, parallel-group Phase II study to explore the potential beneficial effects of safinamide on cognition in non-demented patients with idiopathic Parkinson's disease (PD) and cognitive impairment. #EMR 701165-024Joseph TsuiNeurology2011
MRI/fMRINeuroimaging in concussionAlex RauscherRadiology2011
fMRIMulti-object processing in the ventral streamJason BartonOphthalmology2011
fMRINeuroDevNet substudy on Fetal Alcohol Spectrum DisorderChristian BeaulieuBiomedical Engineering, U of A2011
MRIPreparation for advanced imaging at high field: Correlates in formalin fixed brain and spinal cordCornelia Laule/Wayne MoorePathology & Laboratory Medicine2011
MRINeuroimaging in high altitude climbersAlex RauscherRadiology2011
fMRIThe effects of nabilone on cue-triggered neural response: Exploring treatment options for cannabis abuseElton NganPsychiatry2011
MRIDuration of changes in intracortical excitability and cerebral diffusion after transient ischemic attackLara BoydRehabilitation Sciences2011
MRIA long-term follow-up study of oral ELND005 (AZD-103) in subjects with Alzheimer's DiseaseRobin HsiungNeurology2011
MRIAlzheimer's Disease neuroimaging initiative 2 (ADNI 2)Ging-Yuek Robin HsiungNeurology2011
MRIConcussion in youth ice hockey: New frontiers in diagnostic imagingNaznin Virji-BabulPhysical Therapy2011
fMRIThe contribution of face parts to face processingJason BartonOphthalmology2011
fMRIMetacognitive Monitoring of AttentionKalina ChristoffBrain Research Centre2011
MRIIn Vivo 3-D hip kinematics based on MR Images from patients with femoro-acetabular impingementAntony HodgsonOrthopaedic Engineering2011
MRIA Phase III, multicentre, randomized, parallel-group, double-blinded, placebo controlled study to evaluate theefficacy and safety of Ocrelizumab in adults with primary progressive Multiple SclerosisTony TraboulseeNeurology2011
fMRIMultimodal functional neuroimaging of the networks underlying cognitive impairment in schizophremiaTodd WoodwardPsychiatry2011
MRIMagnetic Resonance Elastography of paitents with prostate cancerTim SalcudeanElectrical Computer Engineering2011
MRIPsychosis, Exercise and Hippocampal PlasticityDonna LangPsychiatry2011
MRSA double-blind, double-dummy, parallel-group study to evaluate the efficacy and safety of Ocrelizumab in comparison to Interferon Beta-1a (Rebif) in patients with Relapsing Multiple Sclerosis ROCHE WA21093/ATony TraboulseeNeurology2011
MRIDASB Pilot StudyJon StoesslNeurology2011
MRSA Multi-centre, randomized, double-blind, placebo-controlled, study of the efficacy of Natalizumab on reducing disability progression in subjects with secondary progressive Multiple SclerosisVirgina DevonshireNeurology2011
fMRIWhite Matter reorganization in response to motor skill trainingLara BoydPhysical Therapy2011
MRICompartmentalization of the human neck muscles sternocleidomastoid and splenius capitisJean-Sebastien BlouinHuman Kinetics2010
MRITEVA Mega Study - Remyelination in MS with Glatiramer Acetate: Insights from Myelin Water imaging and evoked potentialsAlex MacKayPhysics & Astronomy2010
MRIThree-dimensional measurement of knee kinematics in vivo: applications to knee pain and osteoarthritis - in vivo studies, validation bDave WilsonOrthopaedic Engineering2010
fMRIIntegration of cognitive control and motivational informationKalina ChristoffBrain Research Centre2010
MRISpecialized anatomy of baleen whalesRobert ShadwickDepartment of Zoology2010
fMRIExpression versus identity processing n the core and extended face networksJason BartonOphthalmology2010
fMRIRole of exercise on cognition and function in seniors with vascular cognitive impairmentLara BoydPhysical Therapy2010
MRIT1 mapping by 3D T1FFE with variable flip angles for dGEMRICDave WilsonOrthopaedic Engineering2010
MRSA Double-Blind, Placebo-Controlled Study of the safety and Efficacy of ONO-4641 in patients with relapsing Remitting Multiple Sclerosis.Tony TraboulseeMS Clinical Research2010
fMRIIs there a homunculus in the fusiform gyrus?Jason BartonOphthalmology2010
fMRIFunctional Connectivity in Motion-Sensitive Visual CortexKalina Christoff/Debbie GiaschiBRC/Ophthalmology2010
MRIFetal Alcohol Disorders: Gene-environment interactions, predictive biomarkers, and the relationship between structural alterations in the brain and functional outcomesChristian BeaulieuUniversity of Alberta2010
fMRICerebellar Influences in ParkinsonÕs DiseaseMartin McKeownNeurology2010
MRIRelationship beween myelin water fraction and electrophysiology of normal white matter within the corpus callosum and the corticospinal tractAlex MacKayPhysics & Astronomy2010
MRIDevelopment of MRE system for prostate cancer imagingTim SalcudeanElectrical Computer Eng2010
fMRINSDHL mutations, cholesterol metabolism and working memory: neural underpinningsTodd Woodward/Cornelius BoerkoelPsychiatry2010
MRIAlzheimer's disease neuroimaging protocol - Grand Opportunity (ADNI-GO)Robin HsiungNeurology2010
MRIThe Role of CCSVI in Multiple SclerosisTony TraboulseeNeurology2010
fMRINeural networks involved in working memory in SchizophreniaWoodwardPsychiatry2010
MRIEffects of atypical antipsychotics on metabolism, adiposity and weight gain in children and adolescentsAlasdair BarrPsychiatry2010
MRIA dose blinded extension study to the CBAF312A2201 study to evaluate long-term safety, tolerability and efficacy of BAF312 given orally once dialy in patients with relapsing multiple sclerosis CBAF312A2201E1 NovartisJoel OgerNeurology2010
MRIDECIDE: a phase 3 multicentre, double-blind, randomized, parallel-group, monotherapy, active-control study to determine the efficacy and safety of Daclizumab High Yield Process (DAC HYP) versus Avonex (Iinterferon_-1a) in patients with relapsing-remitting multiple sclerosis Protocol #: 205MS301 Biogen IdecTony TraboulseeNeurology2010
MRIELND002: a phase 1b, dose-escalating, randomized, placebo-controlled, double-blinded study to evaluate the safety and efficacy of subcutaneous ELND002 in patients with relapsing forms of Multiple Sclerosis Protocol # ELND002-MS103 Elan Pharmaceuticals IncTony TraboulseeNeurology2010
MRIHepatobiliary imaging in potential living liver donors: Application of high field strength MRI and Primovist contrast agent.Audrey SpielmannRadiology2010
fMRIFunctional Magnetic Resonance Imaging (fMRI) cortical responses in women with overactive bladder before and after pelvic floor therapy.Lynn StothersUrologic Sciences2010
MRIUse of Magnetic Resonance venography to characterize Multiple Sclerosis and other white matter pathologiesAlex Rauscher/Tony TraboulseeUBC MRI Research Centre2009
MRIAssessment of hydration effects on MRI measures of spinal cord volumeRoger Tam/Tony TraboulseeMS/MRI Research Group2009
MRIProject to develop a surgical probe for left atrial appendage occlusion surgeriesJonathan NakaneEngineering Physics2009
MRIDevelopment and validation of a new model of Parkinson's DiseaseDoris DoudetNeurology2009
MRSIn vivo phosphorus magnetic resonance spectroscopy of the muscle in two siblings with unexplained muscle weaknessSylvia Stockler-IpsirogluBiochemical Diseases Clinic, BCCH2009
fMRIVisual and verfbal problem solvingKalina ChristoffBrain Research Centre2009
fMRIEnhancing cognitive vitality and functional independence in older adults with mild cognitive impairment: A randomized trial of aerobic vs. resistance trainingTeresa Ambrose, Todd HandyCentre for Hip Health2009
fMRIIdentifying the neurocognitive impairments associated with recurrent falling among community-dwelling seniorsTeresa Ambrose, Todd HandyCentre for Hip Health2009
fMRIRole of supplementary motor rea in motor imagery and motor function in idndividuals with Parkinson DiseaseLara BoydSchool of rehab sciences2009
fMRIdoing two things at once: how does age influence tasks which challenge both mobility and cognition?Lara BoydSchool of rehab sciences2009
MRSNovartis Pharmaceuticals Canada Inc. Protocol #CBAF312A2201Joel OgerNeurology2009
MRIKinematics and muscle activation of the cervical spine during vehicle rollover accidentsPeter CriptonOrthopaedic Engineering2009
fMRICortical-STN functional connectivity in Parkinson's diseaseMartin McKeownNeurology2009
fMRIInspiratory Muscke Trainingto Improve Respiratory and |neural function in Peoplewith StrokeLara BoydSchool of rehab sciences2009
fMRIControlling Nicotine Craving through down-Regulation of the Insular CortexKalina ChristoffBrain Research Centre2009
MRIGenzyme SubstudyTony TraboulseeMS Clinical Research2009
MRSRoche Genetech study WA21493/ACT4422gTony TraboulseeMS Clinical Research2009
MRSMinocycline (CIS)Tony TraboulseeMS Clinical Research2009
fMRIReal-Time Experience SamplingKalina ChristoffBrain Research Centre2009
fMRIStudies on Music Processing in Persons with Alzheimer DiseaseGing-Yuek Robin HsiungNeurology2009
MRIPREDICT-HD v.2.0Lynn RaymondNeurological Sciences2009
MRIIMAX Study: Maximal simultaneous boost: A dose-escalation study using a maximal simultaneous intraprostatic boost with RapidArc intensity modulated radiotherapy in intermediate risk prostate cancerW. James MorrisBC Cancer Agency2009
fMRIStudies of Treatment Related Compulsive Behaviours and Impulse Control Disorders in Parkeinson's DiseaseVesna SossiPacific Parkinson's Reasearch Centre2009
MRIImaging Dizziness using 3T MRIJohn PhillipsOtology & Neurotology, St. Paul's Hospital2009
MRIA Phase 3, Multicenter, Randomized, double Blind, Placebo-Controlled, Parallel Group, Efficacy and Safety Trial of Bapineuzumab (AAB-001, ELN115727) in Subjects with Mild to Moderate AlzheimerÕs disease who are Apolipoprotein E 4 Non-CarriersGing-Yuek Robin HsiungNeurology2009
MRIA Clinical evaluation for the management of patients with major depressive disorder, single or recurrent episode, with deep brain stimulation Raymond LamPsychiatry2009
MRINeuropsychological and neuropathological outcome from concurrent alcohol use and traumatic brain injury: a longitudinal studyRael LangeRiverview2009
MRIAbdominal shift due to patient positionTim SalcudeanElectrical Computer Eng2009
MRISports related knee injury Pilot (SKIP)Jolanda CibereArthritis Research Centre2009
MRIChanges to skeletal muscle structure during contractionsJames WakelingBiomedical Physiology and Kinesiology SFU2009
MRIAnatomical and diffusion imaging of the human armDinesh PaiComputer Science2008
MRIThe Effect of PerthesÕ Disease on Hip CartilageKishore MulpuriPaediatric Orthopaedics2008
fMRIBrain systems involved in belief formation and re-evaluationTodd WoodwardPsychiatry2008
MRSA Randomised, Double-Blind, Placebo-Controlled, Dose-Ranging Safety and Efficacy Study of Oral ELND005(AZD-103) in AlzheimerÕs DiseaseHoward FeldmanNeurology2008
fMRINeuroimaging and Quality of Life of Children with Developmental Coordination DisorderLara BoydRehabilitation Sciences2008
fMRIAn FMRI Investigation of MindfulnessKalina ChristoffPsychology2008
MRICognitive Characterization of Individuals genetically at risk for frontotemporal dementiaKalina ChristoffPsychology2008
MRIPET studies of Dopamine Turnover and release in Biolar disorder Fluorodopa PET StudyLakshmi YathamPsychiatry2008
MRIEffects of excitatory and inhibitory transcranial magnetic stimulation on motor sequence learningLara BoydRehabilitation Sciences2008
MRIDevelopment of motor function assessment technology based on computed myography (CMG)Dinesh PaiComputer Science2008
MRIVisualization and Real-Time Dosimetry for Prostate BrachytherapyTim SalcudeanElectrical Computer Eng2008
MRIAIM-HIGH Carotid StudyAlex MacKayPhysics and Astronomy2008
MRIPseudoatrophy of the BrainTony TraboulseeNeurology2008
fMRIthe Ultimatum GameElton NganPsychiatry2008
MRIHotel: Co-occurring psychosis, addiction and viral infectionBill HonerPsychiatry2008
MRIInvestigation of intervertebral disc height in REM nd nonREM sleepJerome Fryer2008
MRISpatial and Temporal Aspects of Force Production in ParkinsonÕs Disease: Functional Magnetic Resonance Imaging Study - SWI sequence studyAlex RauscherUBC MRI Research Centre2008
fMRIWaking Salivary Cortisol and DHEA and Serum BDNF Levels in Mood Disorders (the fMRI component)Allan Young/Mario LiottiMood disorders Centre2008
MRSSerono - Atacicept Protocol 28156Peter ReickmannMS Clinical Resarch2008
Centocor Study - a phase 2 double blind, placebo-controlled randomized, dose-ranging study of multiple subcutaneous injections of human monoclonal antibody to 1L-12P40 in subjects with relapsing-remitting multiple sclerosisTony Traboulsee2008
fMRINeuroplasticity following sensory therapy in spinal cord injuryJaimie BorisoffGF Strong Rehab Centre2008
MRIGenzyme Study (2 parts)Tony TraboulseeNeurology2008
fMRINeural correlates of cognitive and motor object representationsTodd HandyPsychology2008
MRIMorphology and dimensions of small pig sinal cord and canal in vivoPeter CriptonOrthopaedic Engineering2008
fMRIBrain Activation: from mechanisms to mobilityJanice EngRehab Sciences2008
fMRIHow Does Excitatory rTMS influence motor cortical activation?Lara BoydRehab Sciences2008
MRIMRI and MathematicsLinda Siegel/Christian BeaulieuBiomeidcal Engineering U of A2008
fMRIThe Effect of Resistance Training on Cognitive Performance, Cortical Plasticity, and Fall Risk in Women Aged 65 to 75 Years Old: A 12-Month Randomized Controlled Trial.Teresa Ambrose, Todd HandyCentre for Hip Health2008
3T vs 1-5T Comparison for imaging myelin waterAlex MacKay2004
MRSN-acetyl-aspartate measures in the thalamus in first episode schizophrenia before and after exposure to atypical antipsychotics during the early phases of treatmentDonna LangRadiology2004
fMRIfMRI Studies in ParkinsonÕs DiseaseMartin McKeownNeurology2004
MRI3T MRI for Functional NeurosurgeryChris HoneyNeurology2004
fMRIMoney matters: An fMRI investigation of the differential response patterns to varying levels of financial reward in healthy people, and patients with schizophreniaElton NganPsychiatry2004
fMRIHippocampo-Prefrontal Connectivity during Semantic Reactivation and during Source MonitoringTodd WoodwardPsychiatry2004
MRSA Pilot Clinical Trial of Intravenous Infusion of Autologous Hematopoietic Progenitor Cells in Patients With Amyotrophic Lateral Sclerosis (ALS)Andy EisenNeurology2004
fMRIMechanisms of Attention OrientingTodd HandyPsychology2004
MRSA prospective study of clinical outcome, brain morphology, cognitive and other functional outcomes in patients after a first episode of maniaLakshmi YathamPsychiatry2004
fMRIHippocampo-prefrontal connectivityTodd WoodwardPsychiatry2004
fMRINew sensory tests for the early detection of dyslexiaDebbie GiaschiOpthamology2004
fMRILow- and high-level motion processing in children with anisometropic or strabismic amblyopiaDebbie GiaschiOpthamology2004
MRILinking Mechanical Imaging with Direct Measurements of BoneÕs Mechanical Properties.Heather McKayOrthopaedic Engineering2004
MRSA Multi-Centered, Randomized Double-Blind, Placebo-Controlled, Parallel Study, Assessing the Add-on effect of Minocycline in Relapsing-Remitting Multiple Sclerosis (RR-MS) Subjects Treated with Glatiramer Acetate (GA): TEVA 9014 StudyTony TraboulseeNeurology2004
MRINeuromuscular control of the head and neck in multidirectional seated perturbations.Timothy InglisHuman Kinetics2004
MRIA biomechanical study of the Dynesys system for flexible posterior stabilization of the lumbar spine: Investigation of facet joint contact under flexion and extension loads using imagingTom OxlandOrthopaedic Engineering2004
fMRIThe cortical networks of real world memory retrievalTodd HandyPsychology2004
fMRIRetinoptic Selection as a Factor in Cortical ProcessingTodd HandyPsychology2004
MRIA randomized Controlled Trial of a Prevention Strategy for Severe Knee Injury in Youth Soccer.John EsdaileRheumatology2004
MRIThree dimensional alignment and early cartilage degeneration in femoroacetabular impingement syndromeDavid WilsonOrthopaedic Engineering2004
fMRIBrain Mechanisms Underlying Human Motion PerceptionDebbie GiaschiOpthamology2004
fMRIFunctional Neuroimaging of Negative Effect in Elite SwimmersElton NganPsychology2004
fMRIDisease markers and predictors of clinical relapse in Remitted Unipolar Depression: An fMRI studyRaymond LamPsychiatry2004
MRIQuantitative Assessment of the Functional Adaption of Bone and Cartilage at the Glenohumeral Joint of Manual Wheelchair UsersDavid WilsonOrthopaedic Engineering2004
MRINondestructive characterization and modelling of bacterial woodSencer AlkanForintek Canada Corp2004
MRI3D Modelling of the Human Vocal Tract Ð Initial InvestigationSydney FelsElectrical Computer Eng2004
fMRISpontaneous forms of thought: an fMRI investigationKalina ChristoffPsychology2004
MRSA Double-Blind, Placebo-Controlled Multicentre Study to Evaluate the Efficacy and Safety of MBP8298 in Subjects with Secondary Progressive Multiple Sclerosis.Tony TraboulseeNeurology2004
fMRIAbstract versus concrete thought during anagram completion: an fMRI investigationKalina ChristoffPsychology2004
MRIAlzheimer Disease Neuroimaging InitiativeHoward FeldmanNeurology2004
fMRIA Functional MRI Study of Face Perception in normal subjects, prosopagnosic patients, and patients with Cerebral Infarcts.Jason BartonOpthamology2004
MRSThe UBC HuntingtonÕs Disease NMR Spectroscopy StudyBlair LevittNeurology2004
MRIThree-dimensional measurement of knee kinematics in vivo: applications to knee pain and osteoarthritis Ð ex vivo cadaver studiesDavid WilsonOrthopaedic Engineering2004
fMRISpatial and Temporal Aspects of Force Production in ParkinsonÕs Disease: Functional Magnetic Resonance Imaging StudyMartin McKeownNeurology2004
fMRIFunctional Neuroimaging of the Hippocampo-Prefrontal Neural System across the Spectrum of SchizophreniaTodd WoodwardPsychiatry2004
fMRIFunctional Neuroimaging of the Effects of Template Complexity in Visual SearchVince Di LolloPsychiatry2004
MRIDW and DCE MRI in prostate cancer diagnosis - a volunteer studyPiotr KozlowskiRadiology2004
MRSA Double-Blind, Placebo-Controlled Multicentre Study to Evaluate the Efficacy and Safety of MBP8298 in Subjects with Secondary Progressive Multiple Sclerosis.Tony TraboulseeNeurology2004
fMRISomatotopy of Speech Motor CortexElton NganPsychiatry2004
fMRIA combined fMRI/DTI analysis of the cerebral motion pathways.Jason BartonOpthamology2004
MRINeuropsychological and neuropathological effects of acute vs chronic alcohol consumption: Outcome from traumatic brain injuryRael LangeRiverview2004
MRIEvaluation of delayed gadolinium enhanced magnetic resonance imaging (dGEMRIC) as a more sensitive measure of intervertebral disc degeneration.David WilsonOrthopaedic Engineering2004
fMRIUsing real-time fMRI feedback in patients with recurrent unipolar depressionKalina ChristoffPsychology2004
fMRIWorking memory representations at different levels of abstraction: an fMRI investigationKalina ChristoffPsychology2004
fMRIAttention in a Dynamic World: Influences of the Optic Flow Field on Visuospatial AttentionTodd HandyPsychology2004
fMRIThe Neural Basis of Vocal ImitationSteven BrownSFU2004
fMRILow-level and High-level Motion Processing in Amblyopic ChildrenDeborah GiaschiOpthamology2004
fMRIFunctional Neuroimaging of the Frontal Lobe during Cognitive Flexibility TasksElton Ngan, Todd WoodwardRiverview2004
MRIEffects of hydration status on magnetic resonance imaging measurements of brain volume and water content.Tony TraboulseeNeurology2004
MRINew Imaging and Diagnostic Modalities: A Novel Quantitative Magnetic Resonance Imaging Technique for the Assessment of Cervical Spondylotic MyelopathyArmin CurtNeurology2004
fMRIMapping networks subserving sequential and associative decision making processesElton NganPsychiatry2004
fMRIWorking memory representations at different levels of abstraction: an fMRI investigationKalina ChristoffPsychology2004
fMRICompensatory Brain Activation after StrokeLara BoydRehabilitation Sciences2004
fMRIForce Production in individuals with stroke or spinal cord injury using functional magnetic resonance imagingJanice EngRehabilitation Sciences2004
fMRIThe Effect of Resistance Training on Cognitive Performance, Cortical Plasticity, and Fall Risk in Women Aged 65 to 75 Yead Old: A 12-Month Randomized Controlled TrialTeresa Ambrose, Todd HandyRehabilitation Sciences2004
fMRIInvestigating prefrontal cortex functions using real-time fMRIKalina ChristoffPsychology2004
fMRIAn fMRI Investigation of RestKalina ChristoffPsychology2004
fMRIThe neural basis of deductive reasoning errors in schizophreniaElton NganPsychiatry2004
fMRITopographical Disorientation in Brain Damaged Patients.Jason BartonOpthamology2004
MRISequence Development for Musculoskeletal Applications in the Knee and HipDavid WilsonOrthopaedic Engineering2004
MRIEffect of acetabular labral tears, repair and resection on hip cartilage loading: A 7T MR studyDavid WilsonOrthopaedic Engineering2004
MRIMonitoring stereotactic radiotherapy treatment of acoustic neuromasStefan ReinsbergPhysics and Astronomy2004
MRIAxial Strain Estimation in Tissue PhantomsDinesh PaiComputer Science2004
MRIThe effect of infection following ACL reconstruction on cartilage healthDavid WilsonOrthopaedic Engineering2004
MRIDividing the undivided: Cardiac dynamics of leatherback and green turtlesDavid JonesZoology2004
MRIImpaction allografting - MR imaging for the bone cement morphology in a cadaveric femur modelTom OxlandOrthopaedic Engineering2004
fMRIMulti-Site Pediatric Network for fMRI Mapping in Childhood EpilepsyBruce BjornsonNeurology2004
MRICharacterising Myelination in Multiple SclerosisAlex MacKayRadiology2004
MRIIn vivo electrophysiological evaluation of DTI depiction of the deep seated principle motor pathways in human brain. A clinical 3T mRI and functional sterotaxy studyChris HoneyNeurology2004
fMRINeurological Changes with Motor LearningNicola HodgesHuman Kinetics2004
MRIEarly Hip Osteoarthritis MRI Pilot: dGEMRIC SubstudyJolanda CibereRheumatology2004
MRIProtocol Development for Diffusion Tensor Imaging of the Human ForearmDinesh PaiComputer Science2004
MRINeuropsychological and neuropathological effects of acute versus chronic alcohol consumption on outcome of traumatic brain injuryRael LangeRiverview2004
fMRIThe cortical basis of motion perception deficits in amblyopiaDebbie GiaschiOpthamology2004
MRITRACK-HDBlair LevittNeurology2004
fMRIThe cortical basis of reading and temporal processing deficits in dyslexiaDebbie GiaschiOpthamology2004
fMRIDoes cortical stimulation facilitate motor learning after stroke?Lara BoydRehabilitation Sciences2004
MRIAlasdair BarrPsychiatry2004
fMRIThe Neuronal Basis of Developmental StutteringMario LiottiSFU Psychology2004
fMRIAn NMR Investigation of PedophiliaKalina ChristoffPsychology2004
MRIDynamic 3D upper airway modeling of the effect of oral appliances for the treatment of obstructive sleep apnea/hypopneaJohn FleethamRespiratory Medicine2004
fMRIRecovery after stroke: what is the role of the undamaged, contralesional cortex?Lara BoydRehabilitation Sciences2004
MRIWhich white matter tracts are involved in distinct psychiatric and surgically treated disorders ?Chris HoneyNeurology2004
fMRIThe neural basis of deductive reasoning errors in schizophrenia: Conflict and emotionElton NganPsychiatry2004
fMRIIntegration of disconfirmatory evidence in pychosis: Cognitive and Neural findingsTodd WoodwardPsychiatry2004