Approved Projects on the 3T Philips Scanner
Study PI Department Year
MRI OLERO (Roche/MN43964) study -A Multi-center, Single-arm, Open-label, Extension, Rollover Study to Evaluate the Long-term Safety and Efficacy of Ocrelizumab in Patients with Multiple Sclerosis.
Study MN43964 (Olero) is a single-arm, open-label extension (OLE), rollover study of ocrelizumab that allows for participants in Parent studies to continue treatment with ocrelizumab and thereby, aims at the continuation of collecting long-term safety and efficacy data. Robert Carruthers MS & NMO Clinical Trials Group 2023
MRI, FLAIR, rs-fMRI, DTI “A Placebo-Controlled Efficacy in iNPH Shunting (PENS) Trial” - Adult Hydrocephalus Study.
Idiopathic Normal Pressure Hydrocephalus is a condition of over- accumulation of cerebrospinal fluid (CSF) commonly seen in the elderly and of unknown cause, with current treatment paradigms involving surgical interventions such as shunting the CSF from the ventricles in the brain to the peritoneum in the abdomen. The current literature surrounding INPH has been insufficient and there remains a need for a placebo controlled study. The Placebo-Controlled Effectiveness in INPH Shunting (PENS) trial is a multi-centre blinded, randomized, placebo-controlled design investigation of CSF shunt surgery. Thomas Zwimpfer Neurosurgery 2023
MRI, FLAIR, DTI, rs-fMRI, tb-fMRI, Single Echo Modulating interhemispheric inhibition after stroke.
The aim of this work is to identify biomarkers to predict who will respond to interventions involving inhibitory brain stimulation after stroke, and generate new knowledge related to our understanding of the mechanisms of inhibitory brain stimulation. While inhibitory brain stimulation shows promise in promoting recovery after stroke when paired with motor practice, its response is variable: we do not know how stroke-related factors influence its subsequent impact on motor-related brain activity. By employing task-based functional magnetic resonance imaging pre and post stimulation, the current study will examine the impact of inhibitory brain stimulation on motor-related brain activity after stroke. Lara Boyd Physical Therapy 2023
MRI, FLAIR, SWI, DWI UX701-CL301. A Randomized, Double-blind, Placebo-controlled, Multicenter, Seamless, Adaptive, Safety, Dose-finding, and Phase 3 Clinical Study of UX701 AAV-mediated Gene Transfer for the Treatment of Wilson Disease, Industry (Ultragenyx) Vladimir Marquez Azalgara Gastroenterology
2022
MRI-PDFF Merck NASH MK-3655-001. A Phase 2b Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-3655 in Individuals with Pre-cirrhotic Nonalcoholic Steatohepatitis Saumya Jayakumar Gastroenterology 2022
MRI, FLAIR, rs-fMRI, DTI, MWI IMPACT 360 for Healthy Agers.
The purpose of this study is to evaluate effects of a multimodal intervention in healthy older adults and elucidate mechanisms driving associated changes. Participants will take part in a 6 month intervention involving exercise, mindfulness, and nutrition. The comprehensive assessment will focus on: cognition, inflammation, microbiome diversity, sleep quality, neurological imaging markers, fitness, cardiovascular health, and well-being. This assessment will: 1) Help us understand the mechanisms behind the benefits of this intervention and any interactive effects and 2) to serve as a normative dataset for replication in clinical populations. Silke Appel- Cresswell Neurology 2022
MRI, FLAIR, rs-fMRI, DWI, MWI, SWI Canadian Longitudinal Study on Aging (CLSA): Follow-up 3, Healthy Brains and Healthy Aging Initiative.
The CLSA Healthy Brains, Healthy Aging Initiative is a six-year study, funded by the Weston Family Foundation, that will create new datasets to enhance the CLSA database and facilitate independent research into the link between lifestyle, the human microbiome, and brain health. The study will involve 6,000 research participants enrolled in the CLSA, including more than 2,500 who will undergo magnetic resonance imaging (MRI) to monitor brain structure and function as they age. The resulting standardized datasets will be available for use by approved public-sector researchers in Canada and internationally. Teresa Liu-Ambrose Physical Therapy 2022
MRI, FLAIR, DWI, QRM, SWI Colchicine for the Prevention of Vascular Events after an Acute Intracerebral Hemorrhage (CoVasc-ICH) – Optional MRI Sub-study.
CoVasc-ICH Optional MRI Sub-Study enrolls interested participants from the main CoVasc-ICH study. This sub-study will try to determine the effects of colchicine on perihematomal edema formation and remote diffusion weighted imaging lesions on MRI. Thalia Field Vancouver Stroke Program 2022
MRI, rs-fMRI, fMRI, MWI, SWI, DTI Mechanisms of non-invasive brain stimulation as a treatment option for patients with Parkinson's (All-Dressed).
In this study, Parkinson’s Disease subjects perform a simple motor task, while they receive subthreshold Electrical Vestibular Stimulation (EVS), and we simultaneously record motor vigour, fMRI and EEG. Different “calibration” stimuli will be delivered in the scanner, and the resultant recordings will be used to train a model to predict vigour from an arbitrary set of stimulation parameters. Precision designed EVS will be later tested outside of the scanner to see if this results in clinically-relevant enhancements in motor task performance. Martin McKeown Neurology 2022
MRI, ASL, DWI, DTI, SWI, MWI (ACQUIRE) Feasibility of multi-domain data acquisition in patients at risk for hypoxic-ischemic brain injury following cardiac arrest: a cohort study.
The ACQUIRE study designed to assess the feasibility data collection in multiple domains (Cerebral Blood Flow using transcranial Doppler, biomarkers of neurologic injury, electroencephalography and neuroimaging). In addition, we are seeking to determine the feasibility of clinical outcome assessment and neuroimaging at 6-months. Don Griesdale (with Will Panenka) Dept. of Medicine, Anaesthesiology 2022
MRI, FLAIR, ASL, rs-fMRI, DTI, SWI FCD - Memory after Concussion 2.0.
This study aims to advance our understanding of why memory problems often persist after concussion, after the brain has seemingly healed. We will be collecting MRI data to confirm that memory complaints after concussion are not directly related to measures of traumatic brain pathology, including corpus callosum white matter integrity and microbleeds. Using resting state fMRI, we will also investigate functional connectivity between the salience network and memory system in the brain in individuals with memory complaints after concussion and those without such complaints to determine whether differences between groups are observable at the level of brain function. Noah Silverberg Psychology 2022
MRI, FLAIR, DTI (MDD), Spectro - single voxel, QRM (MWI) Prediction of Cognitive and Motor Symptom Progression in Multiple Sclerosis Using Myelin Imaging. A.K.A: Longitudinal Observation of Brain and Spinal cord T2 Relaxation – Brief Interlude Subsequent Quantitative Evaluation (LOBSTR BISQUE).
In this study, we will ask our previous volunteers with MS to return 4 years after their original visit so we can collect additional physical, cognitive and myelin MRI data. We will explore whether the amount of myelin at the beginning of the study can predict changes in disability. We will also use new MRI tools to determine what other biological changes, in addition to myelin damage, are linked to progression. Understanding the link between biological changes (in particular myelin) and physical and cognitive changes will allow these more specific imaging methods to be used in clinical trials trying to slow myelin damage and progression. Shannon Kolind MS & NMO Clinical Trials Group 2022
MRI, FLAIR Novel optimized ultrashort echo time multiband hydrogen pulse sequences Radiofrequency Pulse and Pulse Sequence Design for Accelerated Sodium Magnetic Resonance Imaging.
While MRI excels at for detailed images of soft tissue lesions, including those due to traumatic brain injury, it difficult to use MRI to characterize damage to the bone. Ultrashort echo time (UTE) pulse sequences enable the acquisition of signal from tissues with short T2 relaxation time, but they overall scan times tend to be very long due to inefficiencies elsewhere in the sequence. This work aims to develop novel, optimized RF pulse sequences by employing novel MB prepulses. Rebecca Feldman Physics & Astronomy 2022
MRI A randomized, open-label, parallel-group, 18-month Phase 3 study to evaluate the effect of venglustat compared with usual standard of care on left ventricular mass index in participants with Fabry disease and left ventricular hypertrophy” Sanofi EFC16158 CARAT. Anna Lehman Adult metabolic Diseases Clinic 2022
MRI, 3 PLANE, FLAIR
F. Hoffmann-La Roche - FENTREPID (GN41791) study - - Site 327128. NeuroRx Research. A Phase III Multicenter, Randomized, Double Blind, Double Dummy, Parallel Group Study to Evaluate the Efficacy and Safety of Fenebrutinib Compared with Ocrelizumab in Adult Patients with Primary Progressive Multiple Sclerosis.
A study to evaluate the efficacy and safety of fenebrutinib on disability progression in adult participants with Primary Progressive Multiple Sclerosis (PPMS). All eligible participants will be randomly assigned to either daily oral fenebrutinib (or placebo) or intravenous (IV) ocrelizumab (or placebo). Robert Carruthers MS & NMO Clinical Trials Group 2022
MRI, 3 PLANE A randomized, open label, multi-center, active-comparator study to assess the efficacy, safety and tolerability of ofatumumab 20mg sc monthly versus continued current therapy in relapsing-remitting multiple sclerosis after elevation of serum neurofilament light levels (SOSTOS). Novartis
This study will evaluate if relapsing-remitting MS patients that have not had a relapse in the past year would benefit from a switch to ofatumumab versus staying on their continued current therapy. This study will also look at whether an elevated serum neurofilament light (NfL) level predicts enhanced benefit from a switch to ofatumumab. Alice Schabas MS & NMO Clinical Trials Group 2022
MRI, DTI, ihMT Advanced MRI techniques to measure spinal cord microstructure in vivo: development and reproducibility.
This study involves testing advanced MRI techniques (myelin water imaging, inhomogeneous magnetization transfer and diffusion imaging) to measure changes in the spinal cord after spinal cord injury. In this first stage we will optimize these techniques for spinal cord scanning on our 3T scanner and determine reproducibility for white and grey matter regions of interest. Corree Laule ICORD/ MRI Research Centre 2022
MRI A Randomized, Double-Blind, Placebo-Controlled Dose Range Finding Study with Open-Label Extension to Evaluate the Safety. Tolerability, Pharmacokinetics and Pharmacodynamics of LMI070/branaplam when Administered as Weekly Oral Doses in Participants with Early Manifest Huntington's Disease. Blair Leavitt Centre for Huntington Disease 2022
MRI, DWI, FLAIR,
A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel-group, 76-Week Study Evaluating the Safety and Efficacy of Two Doses of Simufilam in Subjects with Mild-to Moderate Alzheimer’s Disease.
This study will investigate the safety and effectiveness of simufilam with those in placebo, in participants who are diagnosed with mild to moderate Alzheimer disease.
Simufilam is an oral drug meant to restore the normal shape and function of a brain protein called filamin A (FLNA). In patients with Alzheimer disease, the shape of FLNA is distorted. This triggers toxic signaling beta amyloid, and ultimately results in brain cell degeneration and inflammation. Robin Hsiung Neurology 2022
MRI, DWI, DTI, FLAIR, rs-fMRI, ASL Roche WN42444 study: A Phase III, Multicenter, Randomized, Parallel-Group, Double-Blind, Placebo-Controlled Study To Evaluate The Efficacy And Safety Of Gantenerumab In Participants At Risk For Or At The Earliest Stages Of Alzheimer’s Disease.
People who have elevated brain amyloid levels may be at risk for or at the earliest stages of Alzheimer’s disease because they have signs of one of two core pathologies of Alzheimer’s disease (abeta amyloid or herein simply “amyloid”), although they do not have symptoms.
The purpose of Study WN42444 is to compare the effects, good or bad, of gantenerumab with those of placebo in participants who are cognitively unimpaired and have elevated levels of amyloid protein in the brain.
Gantenerumab is a man-made antibody that attaches to amyloid in the brain and mobilizes the immune system to remove it. Robin Hsiung Neurology 2022
MRI, tb-fMRI
Transfer of Valence - fMRI equipment testing.
Prior work suggests that emotion not only alters memory for emotional content per se but can also alter memory for and attitudes towards associated experiences, a process known as transfer of valence. The neural correlates of these effects, however, have yet to be thoroughly investigated. To help us gain a better understanding of how emotion affects transfer of valence, we will ask participants to study pairs of images: one object (always neutral) and one scene (negative or neutral). We will then have participants complete a test phase where they will rate the pleasantness of the neutral objects followed by a memory task to determine memory for the pairings in each condition (negative vs. neutral).
Daniela Palombo Psychology 2022
3-point Dixon; Proton spectroscopy Sexual dimorphism in physiological and bioenergetic responses to aerobic exercise.
Physical activity is a necessity for healthy living and dependent on the delivery of oxygen to the working muscles to generate energy. Our understanding of the body’s response to physical activity has primarily been characterized using the “typical 70-kg man”, yet substantial sex-differences in the lungs, heart, blood vessels, blood, and muscle may lead men and women to use different mechanisms to deliver oxygen and produce energy during activity. Our study will investigate these differences with a focus on various muscle characteristics including quantity, structure, fibre type, and respiratory capacity. Robert Boushel Kinesiology/ Fac. Of Education 2022
MRI, DTI, rs-fMRI Left intermittent Theta Burst Stimulation vs. Right Low Frequency Repetitive Transcranial Magnetic Stimulation Effectiveness in Depression and Suicidal Ideation: A Randomized Non-Inferiority Trial (Left vs. Right Non-Inferiority Trial - LeRNIT).
MDD poses a great economic burden on the health care system due to its long-term disability with a low ability to participate in everyday activities. We aim to understand the mechanism of action of rTMS in clinical practice, improve the targeting of this treatment avenue using functional MRI scans, and investigate novel markers, such as heart rate variability, as an indication of treatment response. https://ninet.med.ubc.ca/research/ Fidel Vila-Rodriguez Psychiatry 2021
MRI, MWF, FLAIR VISIONARY-MS: A Phase 2, Randomized, Double-Blind, Parallel Group, Placebo Controlled Study for the Treatment of Visual Pathway Deficits In Chronic Optic Neuropathy to Assess the Efficacy, Safety, Tolerability, and Pharmacokinetics of CNM-Au8 For Remyelination In Stable Relapsing Multiple Sclerosis (RMS). CLENE Nanomedicine, SNAC-Sydney Neuroimaging Analysis Centre. Tony Traboulsee MS & NMO Clinical Trials Group 2021
MRI, DWI, STIR Evaluation the role of transcervical 3D Ultrasound imaging of the oropharynx during transoral robotic surgery - TORS.
Transoral robotic surgery has the potential to provide better surgery outcome to patients with early-stage oropharyngeal SCC, and advances in image guidance during this procedure can optimize resection margins, as well as reduce the risk of complications such as neurovascular injury. The objective of our study is to assess the utility of using 3D transcervical ultrasound to assess oropharyngeal anatomy and pathology and the feasibility of ultrasound-MRI registration for intraoperative image guidance. Eitan Prisman & Tim Salcudean Surgery + Electrical & Computer Engineering 2021
MRI, rs-fMRI, tb-fMRI Functional role of eye movements during motor sequence learning
(Short title: Sensorimotor imaging & learning [SMiLE]).
The sensorimotor imaging & learning (SMiLE) study will evaluate how oculomotor control contributes to implicit motor sequence learning in healthy, young and older adults. Participants will practice a novel skilled reaching task for 3 days and undergo structural and functional magnetic resonance imaging before and after training. We will investigate change in brain connectivity associated with motor sequence learning. Our findings will contribute to better understanding of the underlying mechanisms contributing to skill learning in healthy adults.
Lara Boyd Physical Therapy 2021
MRI, rs-fMRI Technical development time to test new MR-Rapid open bird-cage MR coil for concurrent TMS-MRI applications in phantoms Fidel Vila-Rodriguez Psychiatry 2021
MRI, DWI, FLAIR LIBERTO- Single arm, open label multicenter extension study to evaluate the effectiveness and safety of Ocrelizumab in patients with multiple sclerosis previously enrolled in a F. Hoffmann-La Roche sponsored Ocrelizumab phase IIIb/IV clinical trial. Robert Carruthers MS & NMO Clinical Trials Group 2021
MRI, tb-fMRI
Emotional Localization.
We want to investigate how emotional distractions around us can influence how we see and interact with other non-emotional objects arounds us. Specifically, we want to understand information presented to different senses (e.g., vision, audition) impacts our spatial awareness of the environment. We will utilize specialized behavioral tasks and powerful MRI scanners to help us uncover the underlying patterns of brain activity that guides our attention and action when we are emotionally stimulated.
Rebecca Todd
Psychology
2021
MRI, rs-fMRI, fMRI
Adapt and Avoid – fMRI.
Altered patterns of avoidance behaviours – which entail taking or withholding action to prevent unpleasant outcomes – are a feature of anxiety and depression; however, we only have a limited understanding of the neural circuits that underpin these behaviours. To address this gap in the literature, we adapt an rodent-based investigation of the neural correlates of avoidance behaviours into a human context (in which participants must learn which stimuli are associated with the need to make or withhold a series of button presses in order to avoid an unpleasant outcome). In particular, we focus on the neural representations of stimuli that signal the appropriate avoidance response to be made and the aversive or neutral outcome of the response to these stimuli. Rebecca Todd Psychology 2021
MRI, rs-fMRI, tb-fMRI Cannabis and Polysubstance Use: Imaging Response Inhibition and Stress Exposure (CAPU RISE).
Most stimulant users also use cannabis. The majority of cannabis users report stress reduction and coping motives for their use; however, there remains little biological evidence of cannabis reducing acute stress. This randomized control clinical drug trial employs a range of methods including biosampling, self-reports, actigraphy, and neuroimaging to examine the effects of cannabinoids on stress response, inhibition, and sleep in cannabis and stimulant co-users. Christian Schütz Psychiatry 2021
MRE, MRI-PDFF The Sonic Incytes Liver Incyte System, evaluation of liver fibrosis and steatosis versus MRE and MRI PDFF. SI-CLIN-02.
This study aims to evaluate the correlation of liver elasticity measurements between an investigational ultrasound-based measurement device (Liver Incyte System, manufactured by Sonic Incytes), the standard of care (FibroScan) as well as the non-invasive gold standard (MRE). In addition, this project aims to evaluate the discriminatory ability and investigate cut-offs for different stages of liver disease progression of the Liver Incytes System.
Alnoor Ramji Gastroenterology, GI Research Institute 2021
MRE, MRI-PDFF A Phase 2b Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of MK-3655 in Individuals With Pre-cirrhotic Nonalcoholic Steatohepatitis (Merck NASH).
Alnoor Ramji Gastroenterology, GI Research Institute 2021
MRI, rs-fMRI, fMRI Individualized pathways to recovery after stroke.
Pairing brain stimulation with rehabilitation after stroke is a promising approach. However, early studies of this intervention responses proved to be highly variable. Some people
showed a strong benefit while others did not. The main aim of the proposed program of research is to identify biomarkers that can be used to predict response to brain stimulation interventions.
www.brain.rehab.med.ubc.ca
Lara Boyd Physical Therapy 2021
MRI, MRS, MRS in healthy participants: Neurochemical Atlas.
This study involves creating a metabolic map of the cingulate gyrus using optimized MRS parameters (sLASER, TR/TE=5000/32ms). We will examine the link between each voxel’s glutamate concentration and pain sensitivity (i.e., pain thresholds and laser evoked potentials). Further, the spatial distribution and variability of all metabolic concentrations will be examined. John Kramer, Erin MacMillan ICORD 2021
MRI, rs-fMRI Technical proposal for testing real-time motion detection/ correction patch Fidel Vila-Rodriguez, Erin MacMillan Non-Invasive Neurostimulation Therapies Lab (NINET) / MRI Research Centre 2021
MRI, rs-fMFI, DTI, QRM (MWI) A prospective and longitudinal investigation of concussive and subconcussive mild traumatic brain injury mechanisms in ice hockey.
This study aims to address the public health problem of concussions and subconcussive head impacts in contact sports such as ice hockey. Our investigation will examine the mechanisms of (sub)concussions on brain function changes with mechanical trauma occurred over multiple hockey seasons. Findings from the study will inform how accumulation of trauma leads to long-term health problems including depression and severe personality change. Alex Rauscher, Lyndia Wu MRI Research Centre, Mechanical Engineering 2021
MRI, DWI, SWI, MWI, rs-fMRI Canadian Longitudinal Study on Aging: Coronavirus Disease 2019 (CLSA: COVID) Study.
Canadian Longitudinal Study on Aging COVID-19 Study: This study will compare brain structure, connectivity, and risk of silent stroke in older persons who have a history or symptoms of COVID-19 compared to older people without a history or symptoms of COVID-19. Teresa Liu-Ambrose Physical Therapy, Canada Research Chair in Physical Activity, Mobility, and Cognitive Health 2021
MRI, DWI, ASL "ANAVEX2- 73", A Phase 2b/3, Double-Blind, Randomized, Placebo-Controlled 48-week Safety and Efficacy trial of ANAVEX2-73 for the Treatment of Early Alzheimer’s Disease (AD).
This study will investigate the safety and effectiveness of ANAVEX2-73 in people diagnosed with early to mild Alzheimer disease.
Participants will be randomised to receive either high or low dose ANAVEX2-73 or placebo (33% chance) over a period of 48 weeks. The study drug may protect brain neurons (brain nerve cells) that are usually damaged in Alzheimer’s disease, which may enable ANAVEX2-73 to modify AD.
After the screening and baseline visit, participants will return to the Clinic every 3 months for assessments that include cognitive testing, sleep questionnaires, study partner interviews, occasional safety labs, urinalysis and ECG. Outcome measures include regular assessments of cognitive and functional abilities.
Robin Hsiung Neurology 2021
MRI, DWI, QRMs "EMBARK", Phase 3b Open-Label, Multicenter, Safety Study of BIIB037(aducanumab) in Subjects with Alzheimer’s disease Who Had Previously Participated in the Aducanumab Studies 221AD103, 221AD301, 221AD302 and 221AD205.
The Biogen EMBARK study is an open-label, longitudinal study of the investigational drug aducanumab. The aim of the study is to assess the long-term safety and efficacy of monthly infusions of aducanumab in patients with Alzheimer disease. The study includes magnetic resonance imaging (MRI), positron emission tomography (PET), electrocardiography (ECG), blood sampling, cerebral spinal fluid (CSF) sampling (optional), neuropsychological testing, and caregiver interviews to assess the effects and safety profile of aducanumab. Robin Hsiung Neurology 2020
MRI, DTI, SWI, ASL, Perfusion TRIC-VSI. Trial of Remote Ischemic Conditioning in Vascular Cognitive Impairment.
People with mild vascular cognitive impairment are prone to having little strokes, which can cause changes in cognition over time. Currently there are no treatments for mild vascular cognitive impairment that are approved by Health Canada. This study investigates whether Remote Ischemic Conditioning (cutting off blood flow to a limb temporarily without causing tissue damage) can be implemented successfully by patients, and whether it will improve cognition, brain imaging and blood markers. Thalia Field Neurology 2020
MRI, rs-fMRI, tb-fMRI Modulating interhemispheric inhibition after stroke.
The aim of this work is to identify biomarkers to predict who will respond to interventions involving inhibitory brain stimulation after stroke, and generate new knowledge related to our understanding of the mechanisms of inhibitory brain stimulation. While inhibitory brain stimulation shows promise in promoting recovery after stroke when paired with motor practice, its response is variable: we do not know how stroke-related factors influence its subsequent impact on motor-related brain activity. By employing task-based functional magnetic resonance imaging pre and post stimulation, the current study will examine the impact of inhibitory brain stimulation on motor-related brain activity after stroke. Lara Boyd / Sarah Kraeutner Physical Therapy 2020
MRS MRS Multisite B0 Drift Phantom Study.
Contribution of phantom MRS data to a multisite B0 drift study lead by researchers at Johns Hopkins University. Erin MacMillan MRI Research Centre 2020
MRI, DWI, QRM, MT Natural History of Mild Degenerative Cervical Myelopathy: an observational study.
This study will permit identification of the key clinical, radiological and serum biomarker related variables predicting clinical deterioration of degenerative cervical myelopathy (DCM) patients. Such knowledge will facilitate improvements in the treatment of DCM, allowing surgeons to provide personalized recommendations depending on expected clinical course. Nicolas Dea ICORD, Neurosurgery 2020
MRI, SWI CANARY- Clinical dAta, Natural language pRocessing and eYe tracking for dementia risk stratification.
Our study is attempting to explore the relationship that exists between eye movement patterns, speech patterns, and cognitive decline. This study compares the speech and eye-movements of people with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) to healthy volunteers, to see if there are patterns that can be used to detect Alzheimer’s disease early, and to monitor the progression of Alzheimer’s disease over time.
Link to our study: https://www.vchri.ca/research-study/clinical-data-and-natural-language-processing-early-detection-dementia-canary
Thalia Field Neurology 2020
MRI, rs-fMRI Burnout and Resilience among Medical Professionals during COVID-19.
Burnout in the medical field has long been recognized as a significant problem. Currently available strategies to reduce burnout and build resilience against it are of limited effectiveness and are highly variable in their outcomes. This research will inform the selection and further development of more effective strategies, by using functional magnetic resonance imaging (fMRI) to provide a strong neuroscientific basis for the selection process.
UBC Cognitive Neuroscience of Thought Laboratory: http://www.christofflab.ca/ Kalina Christoff Centre for Brain Health 2020
MRE A Phase 2, randomized, double-blind, placebo-controlled, multicenter, multinational, dose-finding study to evaluate the efficacy and safety of CC-90001 compared with placebo, in subjects with non-alcoholic steatohepatitis (NASH) and Stage 3 or Stage 4 liver fibrosis. Eric Yoshida Gastroenterology 2020
rs-fMRI, Perfusion, MRI
ALLFTD: ARTFL-LEFFTDS Longitudinal Fronto-temporal Lobar Degeneration.
The study aims to evaluate sporadic (s-) and familial (f-) frontotemporal lobar degeneration (FTLD) patients and asymptomatic family members of f-FTLD patients, characterizing the cohorts longitudinally and informing clinical trial design. The study has two arms: a “longitudinal arm” involving a comprehensive assessment of clinical, functional, imaging, and biofluid data collection, and a “biofluid-focused arm” involving limited clinical data to accompany biospecimen collection.
Ian Mackenzie
Pathology & Laboratory Medicine
2020
DWI, FLAIR, SWI
CATIS-ICAD, Combination Antithrombotic Treatment for prevention of recurrent Ischemic Stroke in IntraCranial Atherosclerotic Disease: Protocol for a Pilot randomized trial. Samuel Yip
Vancouver Stroke Program 2020
MRI FH Achilles Tendon Longitudinal (FHATL) Study.
Our study aims to enhance our understanding of the impact of Familial Hypdercholesterolemia on tendon health; a highly under-researched area of significant clinical importance. With the use of non-invasive techniques, we aim to examine various determinants of tendon functional recovery in individuals with newly diagnosed Familial Hypdercholesterolemia. This information is fundamental in identifying if current Familial Hypdercholesterolemia treatments methods reverse the functional and structural effect of the lipid accumulation within the tendon. Alexander Scott Centre for Hip Health & Mobility 2020
MRI, fMRI , BOLD, Neural Recruitment During Spontaneous Thoughts.
People frequently experience thoughts which seem to ‘come out of nowhere’, however, the neural underpinnings of this common psychological happening are poorly understood. Using fMRI scanning, we will investigate neural activity in human brains before a thought reaches one’s awareness, once it reaches awareness, during its subsequent elaboration (as a stream of thought), and during its dissipation. Find out more about this research on our laboratory website: http://www.christofflab.ca/ Kalina Christoff Psychology 2020
MRI, SWI, FLAIR Myelin Water Imaging in NMDA Receptor Autoimmune Encephalitis – Pilot Study.
Autoimmune encephalitis (AIE) is a serious condition caused by misdirected immune response against the brain. Magnetic Resonance Imaging (MRI) is used for the detection of brain abnormalities in many neurological conditions but routine MRI studies are normal in the majority of AIE cases, despite the obvious widespread neurological dysfunction. We aim to determine if there is damage to myelin due to widespread inflammation using Myelin Water Imaging (MWI) in AIE patients and if these relate to abnormalities in cognitive testing, serum neurofilament light-chain levels (a blood biomarker of neuronal damage), and retinal measurements obtained by optical coherence tomography.
Tony Traboulsee MS & NMO Clinical Trials Group 2020
MRI, fMRI, DTI CAN-BIND Validation study- Intergrated Biological Markers for the Prediction of Treatment Response in Depression.
The purpose of our study is to learn about ‘biomarkers’ (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression. This study involves standard treatment for depression. Patients will be treated by a psychiatrist for 16 weeks with an antidepressant medication approved to treat depression. No placebos are being used. Raymond Lam Psychiatry 2020
MRI SEARCH - StrokE and vAscular Risk factors contributing to neuroCognitive decline in adult congenital Heart disease.
Adults with Congenital Heart Disease (ACHD) are at increased risk of clinical and silent infarcts as well as dementia. The SEARCH study will be the first prospective cohort study in ACHD patients evaluating silent cerebrovascular disease over time, and how this is associated with cognitive changes and other vascular risk factors. We will evaluate 400 ACHD patients in BC over 3 years using neuroimaging, cognitive testing, and other imaging and bloodwork to try to address these knowledge gaps. Thalia Field Neurology 2020
MRI-PDFF, MRE A Phase 3, Multinational, Double-Blind, Randomized, Placebo-Controlled Study of MGL-3196 (resmetirom) in Patients With Non-Alcoholic Steatohepatitis (NASH) and Fibrosis to Resolve NASH and Reduce Progression to Cirrhosis and/or Hepatic Decompensation- Madrigal MG-3196-11. Eric Yoshida Gastroenterology 2019
MRI, MRI-PDFF The Sonic Incytes Liver Incyte System, assessment of liver fibrosis and steatosis, SI-CLIN-01.
This study looks to compare the use and results of a new ultrasound based measurement device (Liver Incyte, manufactured by Sonic Incytes) to the standard of care (FibroScan) as well as the non-invasive gold standard (MRE). In addition we would like to compare the fat measurement ability of ultrasound attenuation coefficient compared to that of MRI-PDFF.
Eric Yoshida Gastroenterology 2019
MRI Long-term extension safety and efficacy study of SAR442168 in participants with relapsing Multiple Sclerosis Tony Traboulsee MS & NMO Clinical Trials Group 2019
MRI The Longitudinal Course of Intracortical Myelination and Cognitive Function in Bipolar Disorder Lakshmi Yatham Psychiatry 2019
MRI, rs-fMRI, MRSI Offsetting hippocampal degeneration in moderate to severe TBI.
This randomized control trial is assessing the feasibility and efficacy of an online 16-week intervention employing allocentric spatial navigation tasks to enhance learning and memory capacity and to improve structure and function of the hippocampus following a moderate-severe traumatic brain injury (m-sTBI). Participants will undergo an MR scan, blood collection, and an assessment of behavioural outcomes 7 months and 12 months following a m-sTBI. Participants in the treatment arm complete the online intervention between these time-points while the controls do not. William Panenka Psychiatry 2019
MRI, tb-fMRI, MWF Cortical Responses to Visual Triggers in Urgency Urinary Incontinence Demonstrated Through Functional Magnetic Resonance Imaging. Lynn Stothers ICORD 2019
rs-fMRI Regional brain activation during different forms of response inhibition, comparing young healthy adults with individuals with Bipolar Disorder.
People living with bipolar disorder often have problems with controlling impulsivity. Using MRI, we will identify subcomponents of response inhibition, a specific form of impulsivity. After, participants will receive 3 rounds of Transcranial Magnetic Stimulation (TMS) to test whether or not we can use it to change impulsivity. Christian Schütz Psychiatry 2019
MRI, rs-fMRI The GBA multimodal study Jon Stoessl Neurology, Pacific Parkinson Research Centre 2019
MRI, MEDIC Hemorrhage within the spinal cord after acute traumatic injury - the relationship to hemodynamic management and thromboembolic prophylaxis. Brian Kwon Orthopaedics, ICORD 2019
MRI Linking biomechanical and imaging outcomes to better understand the effects of running on knee joint health.
Running is a very popular activity for many adults. However, a diagnosis of knee osteoarthritis is often seen as a “death sentence” for someone’s recreational running career. This study will provide the first evidence to determine the safety of runners for people with degenerative cartilage due to osteoarthritis.
https://mablab.rehab.med.ubc.ca/currentstudies/ Michael Hunt Physical Therapy 2019
MRI, DWI AXIOMATIC - A Global, Phase 2, Randomized, Double-Blind, Placebo- Controlled, Response-Adaptive Dose-Ranging Study of BMS-986177, an Oral Factor XIa Inhibitor, for the Prevention of New Ischemic Stroke or New Covert Brain Infarction in Patients Receiving Aspirin and Clopidogrel Following Acute Ischemic Stroke or Transient Ischemic Attack (TIA)
Philip Teal/ Thalia Field Neurology 2019
MRI, rs-fMRI, DTI, GRASE Does Opera training sculpt the brain to learn? Study 1- Language Intensive.
Learning how to perform opera is both cognitively and physically demanding, yet some of the students who have been most successful in UBC’s Opera Program have had learning-related disabilities, and appear to have overcome their difficulties, or to have learned compensatory skills that help them not just in opera performance but beyond. The goal of the proposed research is to systematically evaluate and better explain the neural foundations of that observation. In this endeavor, a study is proposed to measure executive function and other learning capabilities before and after a month-long language intensive course that is a required component of UBC opera training, and to determine – through MRI measurement of anatomical changes in fiber tracts in the brain – the neural bases of any observed behavioral improvements. Lara Boyd Physical Therapy 2019
MRI, DWI, SWI CanProCo – Canadian Proactive Cohort Study for People Living with Multiple Sclerosis.
Canadian Proactive Cohort Study for People Living with Multiple Sclerosis (CanProCo) is an observational study designed to better understand the factors that contribute to MS disease progression using tools from different fields such as epidemiology (i.e. number of patients and distribution of diseases), medical imaging, and immunology (blood). Subjects will participate in annual visits over a 5-year period. Tony Traboulsee MS & NMO Clinical Trials Group 2019
MRI A Phase 2B Dose-finding study for SAR442168, A Bruton's tyrosine kinase inhibitor, in participants with relapsing Multiple Sclerosis (Sanofi DRI15928) Tony Traboulsee MS & NMO Clinical Trials Group 2019
MRI An open-label, single-arm 4-year study to evaluate effectiveness and safety of Ocrelizumab treatment in patients with Progressive multiple sclerosis. (Roche Consonance- MN39159) Robert Carruthers MS & NMO Clinical Trials Group 2019
MRI, MWI [Roche] Pilot study of PET (Positron Emission Tomography) Imaging: Correlations with Advanced MRI in MS Robert Carruthers MS & NMO Clinical Trials Group 2019
MRI HOPE- Hip Osteoarthritis Progression Evaluation . Population-Based Longitudinal Cohort Study of Femoroacetabular Impingement of the Hip Using Magnetic Resonance Imaging Outcomes.
The goals of the study are to investigate whether radiographic FAI and physical activity are risk factors for progression of cartilage damage and other MRI outcomes over 7 years. This study includes a randomly selected population of young adults aged 20-49 with and without hip pain. Jolanda Cibere Rheumatology 2019
MRI, DWI AbbVie. A Phase 2 Multiple Dose, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of ABBV-8E12 in Subjects with Early Alzheimer´s Disease.
This is a 96-week Phase 2 clinical trial for people with mild cognitive impairment to mild Alzheimer disease. The study treatment, an anti-Tau agent, may be able to block soluble tau aggregates, and thereby decrease the spreading of tau pathology in brains with tauopathy. Patients who meet all of the inclusion criteria will receive monthly IV study treatment or placebo for the duration of their enrollment. Ging-Yuek Robin Hsiung Neurology 2018
MRI, DTI, rs-fMRI Multi-Site, Prospective, Longitudinal, Cohort Study Measuring Cerebrospinal Fluid Mutant Huntington Protein in Patients with Huntington’s Disease. Blair Leavitt Medical Genetics; Centre for Huntington Disease 2018
fMRI A randomized, double-blinded, sham-controlled cross-over with open-label extension study of theta-burst stimulation transcranial magnetic stimulation in non-fluent/agrammatic variant primary progressive aphasia. Fidel Vila-Rodriguez Psychiatry 2018
MRI, DWI, Elastography Optimizing the management of high-risk and unfavorable intermediate-risk disease: the use of advanced imaging, trans-perineal mapping biopsies, and dual-strength brachytherapy sources to minimize radiation dose to normal tissues [OPTiMAL] Michael Peacock BC Cancer Agency 2018
MRI PET Studies of dopamine turnover and release in bipolar disorder: Montreal Imaging Stress task PET study Lakshmi Yatham Psychiatry 2018
MRI, MTR MAGNIFY: A 2-year Prospective Study to Evaluate the Onset of Action of Mavenclad® in Subjects with Highly Active Relapsing Multiple Sclerosis Robert Carruthers MS & NMO Clinical Trials Group 2018
TMS-fMRI TMS-fMRI - Treatment response in TRD with interleaved TMS-fMRI Fidel Vila-Rodriguez Psychiatry 2018
MRI, MWI Technical development on the Ingenia Elition: MWI, QSM and FLAIR2 Shannon Kolind, Alex Rauscher, Adam Dvorak MRI 2018
MRI; SWI; rs-fMRI HELP_MS;
LEMCOG Healthy Controls - A prospective 24-month investigator sponsored trial to determine the course of cognitive function and how it relates to MRI measures of structural and functional connectivity in healthy controls across time.
Collection of non-Multiple Sclerosis (MS) untreated control data is invaluable for interpretation of data acquired in MS treatment trials on cognitive outcomes such as memory. Advanced MRI techniques detect differences in the brain between people with and without MS. Understanding differences in brain connection patterns in people without MS helps us to understand the biological changes that may lead to cognitive challenges in MS. Shannon Kolind Neurology 2018
MRI; SWI SMOOTH OPERATOR: Smooth Pursuit as a predictor of cerebral small vessel disease.
Cerebral small vessel disease (cSVD) is one of the most prevalent neurological disorders and can lead to problems such as dementia or stroke. However, cSVD is usually only discovered on neuroimaging after symptoms develop. We hope to explore the utility of basic bedside assessments (smooth pursuit eye movements and spontaneous speech patterns) as indicators of the presence and severity of underlying cSVD in pre-symptomatic patients. Thalia Field
Neurology 2018
MRI; fMRI ADNI 3: Alzheimer's Disease neuroimaging initiative 3 Ging-Yuek Robin Hsiung Neurology 2018
MRI, fMRI, DWI SIGNAL: A Phase 2, multi-center, randomized, double-blind, placebo controlled study in subjects with late prodromal and early manifest Huntington’s disease (HD) to assess the safety, tolerability, pharmacokinetics, and efficacy of VX15/2503. Lynn Raymond Centre for Huntington Disease 2018
MRI, fMRI, DWI Aerobic exercise and CogniTIVe functioning in women with breAsT cancer: the ACTIVATE trial.
This study examines the impact of an aerobic exercise intervention on chemotherapy-related cognitive changes (CRCC) in women diagnosed with breast cancer who undergo chemotherapy treatment. The results of this study aim to address the effect and timing of aerobic exercise on CRCC, as well as the outcome of exercise during or following treatment on global measures of brain structure, functioning, and organization through fMRI and EEG assessments.
Kristin Campbell Physical Therapy 2018
MRI, DTI, SWI Mapping the medial forebrain bundle in chronic post-concussive syndrome.
We propose that injury to the medial forebrain bundle is the cause of the chronic
post-concussive syndrome (PCS). This is a proof of concept study involving a single
subject with PCS following a rotational head injury. Trevor Hurwitz with Josue Avecillas- Chasin Psychiatry 2018
MRI, rs-fMRI, DTI, SWI, DBSI, spectrosc. Susac Syndrome Advanced Characterization (SuSAC): A Multidisciplinary Assessment of the Disease including Advanced MRI, Ocular Coherence Tomography, and Neuropsychological Testing.
Susac Syndrome, a rare autoimmune disease often misdiagnosed as Multiple Sclerosis, and is a poorly understood disease with no proven treatments. This study will be the first to combine a multidisciplinary evaluation of clinical status and disease activity with advanced imaging metrics. The results will provide pilot data that may broaden our understanding of disease pathogenesis and allow important structural and functional relationships to emerge. Robert Carruthers MS & NMO Clinical Trials Group 2018
MRI, rs-fMRI, DTI FOXY- Phase 2 Clinical Trial of Intranasal Oxytocin for Frontotemporal Dementia - MRI Research Centre.
The purpose of this study is to evaluate the efficacy of intranasal oxytocin in reducing social apathy in participants with a diagnosis of Fronto-temporal dementia. Robin Hsiung Neurology 2018
MRI, Perfusion, Diffusion When are blood vessels “ready to rupture”? Cerebrovascular health following spinal cord injury.
This study explores the cerebrovascular consequences of intermediate (i.e., 1-2 years) and chronic (i.e., >5 years) exposure to daily autonomic dysreflexia in humans with spinal cord injury. We are interested in finding out if the episodic hypertension associated with autonomic dysreflexia impacts cerebrovascular regulation, which plays a role in predisposing this population to cerebral small vessel disease, overt stroke and cognitive decline. Dr. Andrei Krassioukov ICORD 2017
fMRI Scene construction in spontaneous thought.
This study will look at the neural basis of the thought dynamics and contents; specifically, the difference between freely moving and deliberately constrained thought, both with and without imagery of spatially anchored scenes. To investigate this, we will combine fMRI and experience sampling. Dr. Kalina Christoff (w/ Yvette Graveline) Psychology 2017
MRI, rs-fMRI Next steps for understanding the neuro-cognitive basis of physical activity adherence.
The current study will examine whether individual differences in neural activation using two fMRI experiments predicts future adherence to physical activity over a 6-month period among adults. The first experiment will examine neural responses to the engagement in inhibitory control. The second experiment will examine neural responses to observing health promotion messages related to physical activity and sedentary behavior. Teresa Liu-Ambrose Physical Therapy 2017
rs-fMRI; MRI; DTI; SWI Novel Retinal Biomarkers for Alzheimer's Disease.
Detecting the beginning of Alzheimer disease (AD) in the eye by using a noninvasive imaging device that can show amyloid in the retina. This study is an observational, non-treatment study to identify retinal biomarkers associated with AD, and the outcomes measures include 3T MRI, PiB-PET, 3D/2D Retinal Images, Retinal functional tests, and a variety of cognitive and behavioural interviews. The study will assess the efficacy of the device in rodent models and patients with AD, and if successful, the device may lead to better and earlier diagnosis of AD with lower cost. Robin Hsiung / Prof. Mirza Faisal Beg (SFU) Neurology 2017
MRI ENSEMBLE: An Open-Label, Single-Arm Study to Evaluate the Effectiveness and Safety of Ocrelizumab in Patients with Early Stage Relapsing Remitting Multiple Sclerosis Robert Carruthers MS & NMO Clinical Trials Group 2017
MRI; rs-fMRI An Open-Label Extension Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ISIS 443139 in Huntington’s Disease Patients Who Participated in Prior Investigational Studies of ISIS 443139. ISIS 443139-CS2. Blair Leavitt Medical Genetics; Centre for Huntington Disease 2017
MRI; rs-fMRI Reshaping the Path of Mild Cognitive Impairment by Refining
Exercise Prescription.
In this proposed study, we will study the effects of different types and combinations of exercise training on cognitive function in older adults who are at increased risk for dementia (i.e., mild cognitive impairment). Older adults with mild cognitive impairment represent an ideal target population for intervention strategies, as the preservation of their cognitive function will likely maintain and prolong their ability to live independently and with quality. Furthermore, we will explore how each exercise type improves cognitive function as such information may lead to new discoveries and therapies.
Teresa Liu-Ambrose Physical Therapy 2017
fMRI Thought Dynamics (Spontaneous Thought).
This study will look at the neural basis of the dynamics of thought; particularly, the differences between freely-moving thought and constrained thought. To investigate this, we will combine experience sampling with fMRI. Kalina Christoff Psychology 2017
MRI Synchronizing Exercises, Remedies in Gait and Cognition (SYNERGIC) Trial.
A Randomized Controlled Double Blind Trial.
Physical exercises, cognitive training, and vitamin D are low cost interventions and have the potential to enhance cognitive and mobility function in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI). Currently, it is unclear whether aerobic, resistance, or tone and stretching exercise would have different effects on cognitive performance. We postulate that combined strength and aerobic training will have a better effect on cognition over tone stretching-control exercise in an MCI population. Additionally, we will assess if a multi-domain intervention including cognitive training and vitamin D will have synergistic efficacy. Teresa Liu-Ambrose Physical Therapy 2017
MRI Prostate evaluation for clinically important: MRI vs. standard evaluation procedures (PRECISE). Peter Black (Silvia Chang) Prostate Centre 2017
MRI Development of Magnetic Resonance Elastography System for Liver Imaging Tim Salcudean Electrical and Computer Engineering 2017
MRI Testing Inhomogeneous Magnetization Transfer (TIHMT). Inhomogeneous Magnetization Transfer (ihMT) is a new imaging technique that shows promise for myelin selectivity, which could lead to better detection and treatment of demyelinating diseases such as Multiple Sclerosis. This study will compare ihMT to myelin water fraction images, and assess the two techniques’ selectivity to myelin. Alex MacKay Physics & Astronomy
2017
MRS Implementing GABA editing MRS capacity at UBC Fidel Vila-Rodriguez Psychiatry 2017
MRI, MRS MEDDAY- effect of MD1003 in progressive Multiple Sclerosis: A randomized double blind placebo controlled study Virginia Devonshire Neurology 2017
MRI; rs-fMRI LEM-COG: A Prospective 24-Month Observational Study to Evaluate Neurocognitive Function and Safety in Patients with Relapsing Multiple Sclerosis Who Are Initiating LEMTRADA® Treatment in Routine Clinical Practice Anthony Traboulsee Neurology 2017
MRI LOBSTr: establishing an imaging biomarker for disease progression in multiple sclerosis. MS is a disabling neurological disease with a highly variable clinical course including acute disability (relapses when symptoms appear or worsen) and disease progression (steady accumulation of disability in the absence of relapses). There is currently no approved treatment for progressive MS. A principal pathology of MS is the destruction of myelin, which surrounds nerves to speed up signal conduction. We have developed a magnetic resonance imaging technique that provides quantitative measurements of myelin. Our aim is to establish myelin water imaging as a biomarker for disease progression, allowing efficient clinical trials to establish effective treatment options for progressive MS. Shannon Kolind Neurology 2017
MRI COMB ofatumumab versus teriflunomide in patients with relapsing MS Robert Carruthers MS & NMO Clinical Trials Group 2017
MRI MRI Actuator Evaluation/Liver MRE in Healthy Volunteers Tim Salcudean Electrical and Computer Engineering 2017
MRI Subject-specific Mastication Modeling and its applications in Reconstructive Surgery Sidney FELS (Amir Abdi) Electrical and Computer Engineering 2017
MRI Parotid functional mapping using chemical exchange saturation transfer (CEST) Nevin McVicar / Steven Thomas Medical Physics 2017
fMRI EXML – Effect of aerobic exercise on neuroplasticity and motor learning post stroke Lara Boyd Physical Therapy 2017
MRS Glutamate as a biomarker of pain intensity in the anterior cingulate cortex John Kramer / Corree Laule Blussal Spinal Cord Centre / ICORD 2017
MRI The effects of running on knee cartilage measures in people with and without knee osteoarthritis. A pilot study Michael Hunt Physical Therapy
2017
MRI Pilot Study of PET Imaging: Correlation with Advanced MRI inMS Robert Carruthers Neurology 2017
MRI Advanced MRI measures of normal appearing white matter in progressive solitary sclerosis compared to primary progressive MS, relapsing-remitting MS, and healthy controls Robert Carruthers / Shannon Kolind Neurology 2017
MRI Pilot Study for Myelin Water Imaging in Cervical Spinal Cord Shannon Kolind Neurology 2016
MRI Biomarker Study to Explore Mechanism of Action of Ocrelizumab and B-cell Biology in MS (OBOE Study) Robert Carruthers MS & NMO Clinical Trials Group 2016
fMRI MRI of Cerebrovascular Reactivity Alex Rauscher Paediatrics 2016
fMRI Canadian rTMS Treatment and Biomarker Network in Depression (CARTBIND) Trial Fidel Vila-Rodriguez Psychiatry 2016
fMRI Magnetic Resonance Imaging Biomarkers in Amyotrophic Lateral Sclerosis Sanjay Kalra and Hannah Briemberg Neurology 2016
fMRI Randomized double-blind sham-controlled trial of repetitive transcranial magnetic stimulation (rTMS) for bipolar depression Lakshmi Yatham Psychiatry 2016
MRI Phase III, multicentre, randomized, double-blind, placebo-controlled, parallel-Group, efficacy, and safety study of Crenezumab in patients with prodromal to mild Alzheimer's disease (ABBY 3 Study) Ging-Yuek Robin Hsiung Neurology 2016
MRI Detection of metastatic brain tumours using dynamic glucose enhanced MRI after D-Glucose injection Nevin McVicar BCCA 2016
MRI Advanced Quantitative Imaging in Cervical Spinal Cord Shannon Kolind Neurology 2016
fMRI A Medium Chain Triglyceride INTervention for Alzheimer Disease (A MINT for AD) Phase I Study (MINT-01) Haakon Nygaard Neurology 2016
fMRI Canadian Consortium for Neurodegeneration in Aging (CCNA): The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) Study Ging-Yuek Robin Hsiung Neurology 2016
fMRI The SARTAN-AD Trial: A randomized, open label, proof of concept study of Telmisartan vs. Perindopril in hypertensive mild-moderate Alzheimer's disease patients Ging-Yuek Robin Hsiung Neurology 2016
fMRI The ENGAGE Study: A Phase 3 Multicenter, Randomized, Double-Blind, Placebo Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Aducanumab (BIIB037) in Subjects with Early Alzheimer's Disease Ging-Yuek Robin Hsiung Neurology 2016
fMRI A novel approach to studying postural instability in Parkinson's disease using functional Magnetic Resonance Imaging (fMRI) Mark Carpenter Kinesiology 2016
MRI Importance of diffusely abnormal white matter on disability and progession in MS Cornelia Laule Radiology 2016
MRI VACCINE Study Tony Traboulsee MS Clinical Research 2015
fMRI Neurobiological Correlates of TMS in NHP Doris Doudet Neurology 2015
MRI ARPEGGIO Study Robert Carruthers MS Clinical Research 2015
fMRI Arrowsmith and mTBI Naznin Virji-Babul Physical Therapy 2015
MRI TOPAZ extension study Tony Traboulsee MS Clinical Research 2015
MRI Mild traumatic brain injury genotyping and phenotyping with advanced imaging, Electroencephalography, and cognitive probes (MTBI) William Panenka Psychiatry 2015
MRI Reshaping the Path of Vascular Cognitive Impairment with Resistance Training Teresa Liu-Ambrose Physical Therapy 2015
fMRI Yohimbine Aging and Reproducibility Study Doris Doudet Neurology 2015
fMRI The Integrated Neurostimulation Platform for Neuropsychiatric Research Group - Investigating predictors of treatment response in treatment-resistant depression (TRD) with interleaved TMS/fMRI Fidel Vila-Rodrigues Psychiatry 2015
MRI The AMARANTH Study: A 24-month, Multicenter, Randomized, Double-blind, Placebo-controlled, Parallel-group, Efficacy, Safety, Tolerability, Biomarker, and Pharmacokinetic Study of AZD3293 in Early Alzheimer's Disease Gin-Yuek Robin Hsiung Neurology 2015
fMRI Identifying the Neurocognitive Impairments Associated with Recurrent Falling Among Community-Dwelling Seniors Teresa Liu-Ambrose Physical Therapy 2015
fMRI Improving physical activity using an online monitoring tool: a new model of care for knee osteoarthritis Teresa Liu-Ambrose Physical Therapy 2015
fMRI The Effect of Fit Brains Training on Cognitive Performance in Older Adults Teresa Liu-Ambrose Physical Therapy 2015
MRI A Double-masked, Placebo-controlled Study with Open-label Period to Evaluate the Efficacy and Safety of MEDI-551 in Adult Subjects with Neuromyelitis Optica and Neuromyelitis Optica Spectrum Disorders Robert Carruthers Neurology 2015
MRI Relationship between cervical spinal cord microstructure, metabolite concentrations, and neuropathic pain after spinal cord injury John Kramer ICORD 2015
MRI ISIS 443139-CSI Blair Leavitt Medical Genetics 2015
MRI FYN Study: A Phase 2a Multi-Center Study of 18F-FDG PET, Safety and Tolerability of AZD0530 in Mild Alzheimer's disease Haakon Nygaard Clinic for Alzheimer disease and Related Disorders 2015
fMRI Assessment of “normal appearing” white matter in Parkinson's Disease and its association with cognitive dysfunction Alex MacKay UBC MRI Research Centre 2015
MRI Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS) Ian Mackenzie Pathology 2015
MRI Advancing Research and Treatment for Frontotemporal Lobar Degeneration (ARTFL) Ian Mackenzie Pathology 2015
fMRI Treating Depression in Parkinson's Disease with Transcranial Direct Current Stimulation Jon Stoessl Neurology 2015
fMRI Black Box Theatre of the Mind Polly Gibbons/Ron Burnett Emily Carr University 2015
fMRI Neurological Networks Underlying Cognition in Psychosis Todd Woodward Psychiatry 2015
fMRI Brain Network Interactions Kalina Christoff Brain Research Centre 2015
MRI Comparison of Aripiprazole vs Risperidone on Brain Morphology using MRI - The CARB study Alasdair Barr Psychiatry 2015
MRI Feasibility Study of MR Imaging on Parotid Gland Stimulation (SPIT) Stefan Reinsberg Physics 2015
MRI Tau and Neuroinflammation Imaging in Parkinson's disease and Related Disorders Jon Stoessl Neurology 2015
fMRI Motor Planning Post-Stroke Lara Boyd Physical Therapy 2015
MRI Post Mortem Fetal MRI Alex Rauscher/Denise Pugash Paediatrics 2015
MRI Imaging Tau Accumulation with PBBH3 in Healthy Controls Jon Stoessl Neurology 2014
fMRI Neural corelates of autonomic regulation in elite athletes combining heart rate viariability with fMRI Lara Boyd Physical Therapy 2014
fMRI charactering the impact of silent lesions on stroke recovery using mulimodal neuroimaging Lara Boyd Physical Therapy 2014
MRI Feasibility of spectroscopy and DTI in non-human primates: Pilot study for CIHR Doris Doudet Pacific Parkinson's Research Centre 2014
fMRI Arrowsmith Brain Imaging Lara Boyd Physical Therapy 2014
MRI The Neural Correlates of delusions of reference and recovery from delusions Mahesh Menon Psychiatry 2014
MRI Efficacy of B11B019, Declizumab High Yield Process (DAC-HYP), Monotherapy in subjects with re: An Investigator-Initiated, Multicentre, Phase IV, Open-Label Study to evaluate the biological basis for susceptibility or resistance to disease progression in relapsing-remitting multiple sclerosis patients treated in routine practice with Gilenya for 5 years (IGLOO) Tony Traboulsee MS Clinical Research 2014
fMRI Structural and Functional Correlates of Neuroplastic Change Associated with Stroke Lara Boyd Physical Therapy 2014
MRI What is the relationship between hip musculature; knee joint alignment, pain and function in people with and without knee osteoarthritis? Karim Khan Centre for Hip Health and Mobility 2014
fMRI Sensorimotor plasticity underlying the recovery of skilled walking in people with chronic incomplete SCI Tania Tam & Lara Boyd Physical Therapy 2014
fMRI Characterizing the impact of silent lesions on stroke recovery using multimodal neuroimaging Lara Boyd Physical Therapy 2014
MRI Acoustic Noise Measurement o Noise from single-Shot EPI Stefan Reinsberg Physics & Astronomy 2014
fMRI Structural and Functional Correlates of Neuroplastic Change Associated with Stroke Lara Boyd Physical Therapy 2014
MRI What is the relationship between hip musculature; knee joint alignment, pain and function in people with and without knee osteoarthritis? Karim Khan Family Practice 2014
MRI A randomized controlled study of conventional versus theta-burst repetitive transcranial magnetic stimulation in the treatment of major depressive disorder Fidel Vila-Rodriguez Psychiatry 2014
MRE Magnetic Resonance Elastography of the liver Tim Salcudean Electrical Engineering 2014
MRI Comparative study 0.5T MR Open versus 3.0T MRI - Region of interest: knee David Hart Centre for Hip Health and Mobility 2014
MRI Development of new MRI Techniques for Neuroimaging Alex Rauscher Radiology 2014
MRI Medical Imaging Trial Network of Canada (MINTEC) Protocol C6: Amyloid and glucose PET Imaging in Alzheimer and Vascular Cognitive Impairment patients with significant White Matter Disease Ging-Yuek Robin Hsiung Neurology 2014
MRI The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease Study - A4 Ging-Yuek Robin Hsiung Neurology 2014
MRI A multi-centre, randomized, double-blind, placebo-controlled, phase 3 study to evaluate the efficacy and safety of SA237 as monotherapy in patients with neuromyelitis optica (NMO) and neuromyelitis optica spectrum disorder (NMOSD) Chugai Pharmaceuticals Protocol #: SA-309JG Tony Traboulsee MS Clinical Trials 2014
fMRI Characterizing the Functional Contribution of White Matter Systems within Distributed Neural Networks Ryan D'Arcy SFU 2014
MRI Phase I/II Interventional Clinical Trial of Balloon Venoplasty for Chronic Cerebrospinal Venous Insufficiency in Multiple Sclerosis (CCSVI) Tony Traboulsee Neurology 2013
MRS In Vivo 31P-MR spectroscopy for evaluation of mutation load in a family with MELAS (Mitochontrail Myopathy Encephalopathy, Lactic Acidosis and Stroke like episodes Gabriella Horvath Adult Metabolic Diseases Clinic 2013
MRI A phase-II randomized, double blind, parallel group, placebo-controlled, multi-centre study to evaluate the safety and efficacy of Abatacept in adults with relapsing-remitting Multiple Sclerosis Joel Oger Neurology 2013
fMRI Sensorimotor plasticity underlying the recovery of skilled walkin in people with chronic incomplete spinal cord injury Tania Lam/Lara Boyd Physical Therapy 2013
fMRI PBR28 in healthy controls: serotonergic innervation and Levodopa-derived Dopamine release in PD: an in vivo PET study Vesna Sossi Pacific Parkinson's Reasearch Centre 2013
fMRI Exercise in Parkinson's Disease Jon Stoessl Pacific Parkinson's Reasearch Centre 2013
MRI Myelin Maps ofr T1 and T2 Weighted Scans? Alex Rauscher Radiology 2013
fMRI Neural Basis of Spontneous Thought Kalina Christoff Brain Research Centre 2013
fMRI Regional Brain Activiation during different forms of response inhibition comparing young health adults with problem stimulant users and problem gambers Christian Schutz Psychiatry 2013
MRI Cortical inhibition in unipolar and bipolar depression compared to healthy subjects: a TMS-EEG study Lakshmi Yatham Psychiatry 2013
MRE FTPC: Focal Therapy for Prostate Cancer: A study using focal low dose rate brachytherapy as an alternative to active surveillance and radical treatment forfavourabe risk prostate cancer James Morris BC Cancer Agency 2013
MRI Comparative study 0.5T Open MR vs 3.0T MRI: Region of interest - Knee David Hart Centre for Hip Health and Mobility 2013
MRI Characterization of Dementia due to Mixed Alzheimer and subcortical vascular pathology Robin Hsiung Neurology 2013
fMRI Is there a homunculus in the visual cortex? Jason Barton Ophthalmology 2013
MRI Serial comparisons of abdominal and neurological MRI scans of patients with refractory pychosis disorders (SCAN MRI) Alasdair Barr Psychiatry 2013
MRI DIAN-TU-001: a phase II/III randomized, double-blind, placebo-controled multi-centre study of 2 potential disease modifying therapies in individuals at risk for and with dominantly inherited Alzheimer's disease Robin Hsiung Neurology 2013
MRI T2 relaxometry MRI for the diagnosis of prostate cancer Piotr Kozlowski UBC MRI Research Centre 2013
MRI Development of a new imaging technique of knee cartilage in osteoarthritis Alex Rauscher Radiology 2013
fMRI Exercise-induced and music-induced brain connectivity changes in Parkinson's Disease Martin McKeown Neurology 2013
MRI Tractography after bilateral anterior capsulotomy Andrew Howard Psychiatry 2013
fMRI Neural correlates of autonomic regulation in elite athletes combining heart rate variability with fMRI Lara Boyd Physical Therapy 2013
MRI TRACK-ON Blair Leavitt Neurology 2012
MRI Complications of Parkinson's Disease: The Dopamnergic Basis of Depression; Study 1 Jon Stoessl Neurology 2012
MRI IMPAKT-Hip: Natural History of FAI Study Jolanda Cibere Orthopaedics 2012
fMRI Effects of Exposure to Air Pollution on Congitive Function (EAPOC) Christopher Carlsten Respiratory Medicine 2012
fMRI Assessment of Cerebrovascular function using MRI and Blood Gas Manipulation William Sheel Human Kinetics 2012
MRI Study of Myelination in Multiple Sclerosis using MRI and MEPs Tony Traboulsee Neurology 2012
MRI Pseudo-atrophy of the brain in Multiple Sclerosis (Extension) Tony Traboulsee Neurology 2012
fMRI Cognitive characterization of Individuals Genetically At-Risk for Frontotemporal Dementia Claudia Jacova Neurology 2012
MRI MITIGATE-HD Blair Leavitt Neurology 2012
FfMRI Integrated biological markers for the prediction of treatment response in depression Raymond Lam Psychiatry 2012
MRI A Phase II, multicentre, randomized, parallel-group, partially blinded, placebo and Avonex controlled dose finding study to evaluate the efficacy as measured by brain MRI lesions, and safety oftwo does regimens of ocrelizumab in patients with relapsing-remitting multiple sclerosis ROCHE WA21493C/CAT4422g Lorne Kastrukoff Neurology 2012
MRI A PET study of NE Transporter Occupancy and Symptom Response in Depressed Patients Treated with Quetiapine XR Lakshmi Yatham Neurology 2012
fMRI Clinical and neural funcitoning outcomes following group-based family cognitive-behaviour therapy in pediatric obsessive-compulsive disorder (OCD) Evelyn Stewart Paediatrics 2012
MRI The Relationship Between Serotonergic Innervation and Levodopa-Derived Dopamine Release in Parkinson's disease: an in vivo PET Study Jon Stoessl Neurology 2012
MRI Advanced MRI Measures of Repair in Ocrelizumab treated Patients Tony Traboulsee Neurology 2012
rs-fMRI Effects of Brain Magnesium concentration on 31P-MRS and resting state fMRI in ParkinsonÕs disease Martin McKeown Neurology 2012
fMRI Brain Activation during Motor Tasks after SCI Janice Eng Physical Therapy 2012
fMRI Cortical and Subcortical Effects of Galvanic Vestibular Stimulation in Parkinson's Disease Martin McKeown Neurology 2012
MRI Anatomical and functional MRI Correlates of Cognitive Dysfunction in Multiple Sclerosis Alex MacKay Physics & Astronomy 2012
fMRI Neural and Biochemical Correlates of Inner Time Consciousness in Professional Swimmers Georg Northoff Psychiatry 2012
MRI The Evolution of Parkinson's Disease Jon Stoessl Neurology 2012
MRS A Longitudinal Comparison of Aripiprazole vs. Higher Metabolic Risk Antipsychotic Drugs on Adiposity Using MRI (CALM study) Alasdair Barr Psychiatry 2012
fMRI Can exercise improve cancer associated cognitive dysfunction Kristin Campbell Physical Therapy 2011
MRI A multi-centre, randomized, double-blind, placebo-controlled, parallel-group, phase II trial to investigate the efficacy and safety of weekly intra-articular (i.a.) injections of 10, 30, and 100 _g of AS902330 for three consecutive weeks in patients with acute cartilage injury of the knee David Li Radiology 2011
MRI Baminercept: A Multicentre, Randomized, Blinded, Placebo-Controlled, Dose-Escalation Study to Evaluate the Penetration and Pharmacodynamic Effects of Baminercept in the CSF and Safety in Subjects with Secondary Progressive Multiple Sclerosis Tony Traboulsee Neurology 2011
MRI Controlled High Risk Avonex Multiple Sclerosis Prevention Study in Ongoing Neurological Surveillance: CHAMPIONS Continuation Study Tony Traboulsee Neurology 2011
MRI Interhemispheric contributions to neuroplasticity and motor learning after stroke Lara Boyd Rehabilitation Sciences 2011
fMRI A double-blind, randomized, placebo-controlled, parallel-group Phase II study to explore the potential beneficial effects of safinamide on cognition in non-demented patients with idiopathic Parkinson's disease (PD) and cognitive impairment. #EMR 701165-024 Joseph Tsui Neurology 2011
MRI/fMRI Neuroimaging in concussion Alex Rauscher Radiology 2011
fMRI Multi-object processing in the ventral stream Jason Barton Ophthalmology 2011
fMRI NeuroDevNet substudy on Fetal Alcohol Spectrum Disorder Christian Beaulieu Biomedical Engineering, U of A 2011
MRI Preparation for advanced imaging at high field: Correlates in formalin fixed brain and spinal cord Cornelia Laule/Wayne Moore Pathology & Laboratory Medicine 2011
MRI Neuroimaging in high altitude climbers Alex Rauscher Radiology 2011
fMRI The effects of nabilone on cue-triggered neural response: Exploring treatment options for cannabis abuse Elton Ngan Psychiatry 2011
MRI Duration of changes in intracortical excitability and cerebral diffusion after transient ischemic attack Lara Boyd Rehabilitation Sciences 2011
MRI A long-term follow-up study of oral ELND005 (AZD-103) in subjects with Alzheimer's Disease Robin Hsiung Neurology 2011
MRI Alzheimer's Disease neuroimaging initiative 2 (ADNI 2) Ging-Yuek Robin Hsiung Neurology 2011
MRI Concussion in youth ice hockey: New frontiers in diagnostic imaging Naznin Virji-Babul Physical Therapy 2011
fMRI The contribution of face parts to face processing Jason Barton Ophthalmology 2011
fMRI Metacognitive Monitoring of Attention Kalina Christoff Brain Research Centre 2011
MRI In Vivo 3-D hip kinematics based on MR Images from patients with femoro-acetabular impingement Antony Hodgson Orthopaedic Engineering 2011
MRI A Phase III, multicentre, randomized, parallel-group, double-blinded, placebo controlled study to evaluate theefficacy and safety of Ocrelizumab in adults with primary progressive Multiple Sclerosis Tony Traboulsee Neurology 2011
fMRI Multimodal functional neuroimaging of the networks underlying cognitive impairment in schizophremia Todd Woodward Psychiatry 2011
MRI Magnetic Resonance Elastography of paitents with prostate cancer Tim Salcudean Electrical Computer Engineering 2011
MRI Psychosis, Exercise and Hippocampal Plasticity Donna Lang Psychiatry 2011
MRS A double-blind, double-dummy, parallel-group study to evaluate the efficacy and safety of Ocrelizumab in comparison to Interferon Beta-1a (Rebif) in patients with Relapsing Multiple Sclerosis ROCHE WA21093/A Tony Traboulsee Neurology 2011
MRI DASB Pilot Study Jon Stoessl Neurology 2011
MRS A Multi-centre, randomized, double-blind, placebo-controlled, study of the efficacy of Natalizumab on reducing disability progression in subjects with secondary progressive Multiple Sclerosis Virgina Devonshire Neurology 2011
fMRI White Matter reorganization in response to motor skill training Lara Boyd Physical Therapy 2011
MRI Compartmentalization of the human neck muscles sternocleidomastoid and splenius capitis Jean-Sebastien Blouin Human Kinetics 2010
MRI TEVA Mega Study - Remyelination in MS with Glatiramer Acetate: Insights from Myelin Water imaging and evoked potentials Alex MacKay Physics & Astronomy 2010
MRI Three-dimensional measurement of knee kinematics in vivo: applications to knee pain and osteoarthritis - in vivo studies, validation b Dave Wilson Orthopaedic Engineering 2010
fMRI Integration of cognitive control and motivational information Kalina Christoff Brain Research Centre 2010
MRI Specialized anatomy of baleen whales Robert Shadwick Department of Zoology 2010
fMRI Expression versus identity processing n the core and extended face networks Jason Barton Ophthalmology 2010
fMRI Role of exercise on cognition and function in seniors with vascular cognitive impairment Lara Boyd Physical Therapy 2010
MRI T1 mapping by 3D T1FFE with variable flip angles for dGEMRIC Dave Wilson Orthopaedic Engineering 2010
MRS A Double-Blind, Placebo-Controlled Study of the safety and Efficacy of ONO-4641 in patients with relapsing Remitting Multiple Sclerosis. Tony Traboulsee MS Clinical Research 2010
fMRI Is there a homunculus in the fusiform gyrus? Jason Barton Ophthalmology 2010
fMRI Functional Connectivity in Motion-Sensitive Visual Cortex Kalina Christoff/Debbie Giaschi BRC/Ophthalmology 2010
MRI Fetal Alcohol Disorders: Gene-environment interactions, predictive biomarkers, and the relationship between structural alterations in the brain and functional outcomes Christian Beaulieu University of Alberta 2010
fMRI Cerebellar Influences in ParkinsonÕs Disease Martin McKeown Neurology 2010
MRI Relationship beween myelin water fraction and electrophysiology of normal white matter within the corpus callosum and the corticospinal tract Alex MacKay Physics & Astronomy 2010
MRI Development of MRE system for prostate cancer imaging Tim Salcudean Electrical Computer Eng 2010
fMRI NSDHL mutations, cholesterol metabolism and working memory: neural underpinnings Todd Woodward/Cornelius Boerkoel Psychiatry 2010
MRI Alzheimer's disease neuroimaging protocol - Grand Opportunity (ADNI-GO) Robin Hsiung Neurology 2010
MRI The Role of CCSVI in Multiple Sclerosis Tony Traboulsee Neurology 2010
fMRI Neural networks involved in working memory in Schizophrenia Woodward Psychiatry 2010
MRI Effects of atypical antipsychotics on metabolism, adiposity and weight gain in children and adolescents Alasdair Barr Psychiatry 2010
MRI A dose blinded extension study to the CBAF312A2201 study to evaluate long-term safety, tolerability and efficacy of BAF312 given orally once dialy in patients with relapsing multiple sclerosis CBAF312A2201E1 Novartis Joel Oger Neurology 2010
MRI DECIDE: a phase 3 multicentre, double-blind, randomized, parallel-group, monotherapy, active-control study to determine the efficacy and safety of Daclizumab High Yield Process (DAC HYP) versus Avonex (Iinterferon_-1a) in patients with relapsing-remitting multiple sclerosis Protocol #: 205MS301 Biogen Idec Tony Traboulsee Neurology 2010
MRI ELND002: a phase 1b, dose-escalating, randomized, placebo-controlled, double-blinded study to evaluate the safety and efficacy of subcutaneous ELND002 in patients with relapsing forms of Multiple Sclerosis Protocol # ELND002-MS103 Elan Pharmaceuticals Inc Tony Traboulsee Neurology 2010
MRI Hepatobiliary imaging in potential living liver donors: Application of high field strength MRI and Primovist contrast agent. Audrey Spielmann Radiology 2010
fMRI Functional Magnetic Resonance Imaging (fMRI) cortical responses in women with overactive bladder before and after pelvic floor therapy. Lynn Stothers Urologic Sciences 2010
MRI Use of Magnetic Resonance venography to characterize Multiple Sclerosis and other white matter pathologies Alex Rauscher/Tony Traboulsee UBC MRI Research Centre 2009
MRI Assessment of hydration effects on MRI measures of spinal cord volume Roger Tam/Tony Traboulsee MS/MRI Research Group 2009
MRI Project to develop a surgical probe for left atrial appendage occlusion surgeries Jonathan Nakane Engineering Physics 2009
MRI Development and validation of a new model of Parkinson's Disease Doris Doudet Neurology 2009
MRS In vivo phosphorus magnetic resonance spectroscopy of the muscle in two siblings with unexplained muscle weakness Sylvia Stockler-Ipsiroglu Biochemical Diseases Clinic, BCCH 2009
fMRI Visual and verfbal problem solving Kalina Christoff Brain Research Centre 2009
fMRI Enhancing cognitive vitality and functional independence in older adults with mild cognitive impairment: A randomized trial of aerobic vs. resistance training Teresa Ambrose, Todd Handy Centre for Hip Health 2009
fMRI Identifying the neurocognitive impairments associated with recurrent falling among community-dwelling seniors Teresa Ambrose, Todd Handy Centre for Hip Health 2009
fMRI Role of supplementary motor rea in motor imagery and motor function in idndividuals with Parkinson Disease Lara Boyd School of rehab sciences 2009
fMRI doing two things at once: how does age influence tasks which challenge both mobility and cognition? Lara Boyd School of rehab sciences 2009
MRS Novartis Pharmaceuticals Canada Inc. Protocol #CBAF312A2201 Joel Oger Neurology 2009
MRI Kinematics and muscle activation of the cervical spine during vehicle rollover accidents Peter Cripton Orthopaedic Engineering 2009
fMRI Cortical-STN functional connectivity in Parkinson's disease Martin McKeown Neurology 2009
fMRI Inspiratory Muscke Trainingto Improve Respiratory and |neural function in Peoplewith Stroke Lara Boyd School of rehab sciences 2009
fMRI Controlling Nicotine Craving through down-Regulation of the Insular Cortex Kalina Christoff Brain Research Centre 2009
MRI Genzyme Substudy Tony Traboulsee MS Clinical Research 2009
MRS Roche Genetech study WA21493/ACT4422g Tony Traboulsee MS Clinical Research 2009
MRS Minocycline (CIS) Tony Traboulsee MS Clinical Research 2009
fMRI Real-Time Experience Sampling Kalina Christoff Brain Research Centre 2009
fMRI Studies on Music Processing in Persons with Alzheimer Disease Ging-Yuek Robin Hsiung Neurology 2009
MRI PREDICT-HD v.2.0 Lynn Raymond Neurological Sciences 2009
MRI IMAX Study: Maximal simultaneous boost: A dose-escalation study using a maximal simultaneous intraprostatic boost with RapidArc intensity modulated radiotherapy in intermediate risk prostate cancer W. James Morris BC Cancer Agency 2009
fMRI Studies of Treatment Related Compulsive Behaviours and Impulse Control Disorders in Parkeinson's Disease Vesna Sossi Pacific Parkinson's Reasearch Centre 2009
MRI Imaging Dizziness using 3T MRI John Phillips Otology & Neurotology, St. Paul's Hospital 2009
MRI A Phase 3, Multicenter, Randomized, double Blind, Placebo-Controlled, Parallel Group, Efficacy and Safety Trial of Bapineuzumab (AAB-001, ELN115727) in Subjects with Mild to Moderate AlzheimerÕs disease who are Apolipoprotein E 4 Non-Carriers Ging-Yuek Robin Hsiung Neurology 2009
MRI A Clinical evaluation for the management of patients with major depressive disorder, single or recurrent episode, with deep brain stimulation Raymond Lam Psychiatry 2009
MRI Neuropsychological and neuropathological outcome from concurrent alcohol use and traumatic brain injury: a longitudinal study Rael Lange Riverview 2009
MRI Abdominal shift due to patient position Tim Salcudean Electrical Computer Eng 2009
MRI Sports related knee injury Pilot (SKIP) Jolanda Cibere Arthritis Research Centre 2009
MRI Changes to skeletal muscle structure during contractions James Wakeling Biomedical Physiology and Kinesiology SFU 2009
MRI Anatomical and diffusion imaging of the human arm Dinesh Pai Computer Science 2008
MRI The Effect of PerthesÕ Disease on Hip Cartilage Kishore Mulpuri Paediatric Orthopaedics 2008
fMRI Brain systems involved in belief formation and re-evaluation Todd Woodward Psychiatry 2008
MRS A Randomised, Double-Blind, Placebo-Controlled, Dose-Ranging Safety and Efficacy Study of Oral ELND005(AZD-103) in AlzheimerÕs Disease Howard Feldman Neurology 2008
fMRI Neuroimaging and Quality of Life of Children with Developmental Coordination Disorder Lara Boyd Rehabilitation Sciences 2008
fMRI An FMRI Investigation of Mindfulness Kalina Christoff Psychology 2008
MRI Cognitive Characterization of Individuals genetically at risk for frontotemporal dementia Kalina Christoff Psychology 2008
MRI PET studies of Dopamine Turnover and release in Biolar disorder Fluorodopa PET Study Lakshmi Yatham Psychiatry 2008
MRI Effects of excitatory and inhibitory transcranial magnetic stimulation on motor sequence learning Lara Boyd Rehabilitation Sciences 2008
MRI Development of motor function assessment technology based on computed myography (CMG) Dinesh Pai Computer Science 2008
MRI Visualization and Real-Time Dosimetry for Prostate Brachytherapy Tim Salcudean Electrical Computer Eng 2008
MRI AIM-HIGH Carotid Study Alex MacKay Physics and Astronomy 2008
MRI Pseudoatrophy of the Brain Tony Traboulsee Neurology 2008
fMRI the Ultimatum Game Elton Ngan Psychiatry 2008
MRI Hotel: Co-occurring psychosis, addiction and viral infection Bill Honer Psychiatry 2008
MRI Investigation of intervertebral disc height in REM nd nonREM sleep Jerome Fryer 2008
MRI Spatial and Temporal Aspects of Force Production in ParkinsonÕs Disease: Functional Magnetic Resonance Imaging Study - SWI sequence study Alex Rauscher UBC MRI Research Centre 2008
fMRI Waking Salivary Cortisol and DHEA and Serum BDNF Levels in Mood Disorders (the fMRI component) Allan Young/Mario Liotti Mood disorders Centre 2008
MRS Serono - Atacicept Protocol 28156 Peter Reickmann MS Clinical Resarch 2008
Centocor Study - a phase 2 double blind, placebo-controlled randomized, dose-ranging study of multiple subcutaneous injections of human monoclonal antibody to 1L-12P40 in subjects with relapsing-remitting multiple sclerosis Tony Traboulsee 2008
fMRI Neuroplasticity following sensory therapy in spinal cord injury Jaimie Borisoff GF Strong Rehab Centre 2008
MRI Genzyme Study (2 parts) Tony Traboulsee Neurology 2008
fMRI Neural correlates of cognitive and motor object representations Todd Handy Psychology 2008
MRI Morphology and dimensions of small pig sinal cord and canal in vivo Peter Cripton Orthopaedic Engineering 2008
fMRI Brain Activation: from mechanisms to mobility Janice Eng Rehab Sciences 2008
fMRI How Does Excitatory rTMS influence motor cortical activation? Lara Boyd Rehab Sciences 2008
MRI MRI and Mathematics Linda Siegel/Christian Beaulieu Biomeidcal Engineering U of A 2008
fMRI The Effect of Resistance Training on Cognitive Performance, Cortical Plasticity, and Fall Risk in Women Aged 65 to 75 Years Old: A 12-Month Randomized Controlled Trial. Teresa Ambrose, Todd Handy Centre for Hip Health 2008
3T vs 1-5T Comparison for imaging myelin water Alex MacKay 2004
MRS N-acetyl-aspartate measures in the thalamus in first episode schizophrenia before and after exposure to atypical antipsychotics during the early phases of treatment Donna Lang Radiology 2004
fMRI fMRI Studies in ParkinsonÕs Disease Martin McKeown Neurology 2004
MRI 3T MRI for Functional Neurosurgery Chris Honey Neurology 2004
fMRI Money matters: An fMRI investigation of the differential response patterns to varying levels of financial reward in healthy people, and patients with schizophrenia Elton Ngan Psychiatry 2004
fMRI Hippocampo-Prefrontal Connectivity during Semantic Reactivation and during Source Monitoring Todd Woodward Psychiatry 2004
MRS A Pilot Clinical Trial of Intravenous Infusion of Autologous Hematopoietic Progenitor Cells in Patients With Amyotrophic Lateral Sclerosis (ALS) Andy Eisen Neurology 2004
fMRI Mechanisms of Attention Orienting Todd Handy Psychology 2004
MRS A prospective study of clinical outcome, brain morphology, cognitive and other functional outcomes in patients after a first episode of mania Lakshmi Yatham Psychiatry 2004
fMRI Hippocampo-prefrontal connectivity Todd Woodward Psychiatry 2004
fMRI New sensory tests for the early detection of dyslexia Debbie Giaschi Opthamology 2004
fMRI Low- and high-level motion processing in children with anisometropic or strabismic amblyopia Debbie Giaschi Opthamology 2004
MRI Linking Mechanical Imaging with Direct Measurements of BoneÕs Mechanical Properties. Heather McKay Orthopaedic Engineering 2004
MRS A Multi-Centered, Randomized Double-Blind, Placebo-Controlled, Parallel Study, Assessing the Add-on effect of Minocycline in Relapsing-Remitting Multiple Sclerosis (RR-MS) Subjects Treated with Glatiramer Acetate (GA): TEVA 9014 Study Tony Traboulsee Neurology 2004
MRI Neuromuscular control of the head and neck in multidirectional seated perturbations. Timothy Inglis Human Kinetics 2004
MRI A biomechanical study of the Dynesys system for flexible posterior stabilization of the lumbar spine: Investigation of facet joint contact under flexion and extension loads using imaging Tom Oxland Orthopaedic Engineering 2004
fMRI The cortical networks of real world memory retrieval Todd Handy Psychology 2004
fMRI Retinoptic Selection as a Factor in Cortical Processing Todd Handy Psychology 2004
MRI A randomized Controlled Trial of a Prevention Strategy for Severe Knee Injury in Youth Soccer. John Esdaile Rheumatology 2004
MRI Three dimensional alignment and early cartilage degeneration in femoroacetabular impingement syndrome David Wilson Orthopaedic Engineering 2004
fMRI Brain Mechanisms Underlying Human Motion Perception Debbie Giaschi Opthamology 2004
fMRI Functional Neuroimaging of Negative Effect in Elite Swimmers Elton Ngan Psychology 2004
fMRI Disease markers and predictors of clinical relapse in Remitted Unipolar Depression: An fMRI study Raymond Lam Psychiatry 2004
MRI Quantitative Assessment of the Functional Adaption of Bone and Cartilage at the Glenohumeral Joint of Manual Wheelchair Users David Wilson Orthopaedic Engineering 2004
MRI Nondestructive characterization and modelling of bacterial wood Sencer Alkan Forintek Canada Corp 2004
MRI 3D Modelling of the Human Vocal Tract Ð Initial Investigation Sydney Fels Electrical Computer Eng 2004
fMRI Spontaneous forms of thought: an fMRI investigation Kalina Christoff Psychology 2004
MRS A Double-Blind, Placebo-Controlled Multicentre Study to Evaluate the Efficacy and Safety of MBP8298 in Subjects with Secondary Progressive Multiple Sclerosis. Tony Traboulsee Neurology 2004
fMRI Abstract versus concrete thought during anagram completion: an fMRI investigation Kalina Christoff Psychology 2004
MRI Alzheimer Disease Neuroimaging Initiative Howard Feldman Neurology 2004
fMRI A Functional MRI Study of Face Perception in normal subjects, prosopagnosic patients, and patients with Cerebral Infarcts. Jason Barton Opthamology 2004
MRS The UBC HuntingtonÕs Disease NMR Spectroscopy Study Blair Levitt Neurology 2004
MRI Three-dimensional measurement of knee kinematics in vivo: applications to knee pain and osteoarthritis Ð ex vivo cadaver studies David Wilson Orthopaedic Engineering 2004
fMRI Spatial and Temporal Aspects of Force Production in ParkinsonÕs Disease: Functional Magnetic Resonance Imaging Study Martin McKeown Neurology 2004
fMRI Functional Neuroimaging of the Hippocampo-Prefrontal Neural System across the Spectrum of Schizophrenia Todd Woodward Psychiatry 2004
fMRI Functional Neuroimaging of the Effects of Template Complexity in Visual Search Vince Di Lollo Psychiatry 2004
MRI DW and DCE MRI in prostate cancer diagnosis - a volunteer study Piotr Kozlowski Radiology 2004
MRS A Double-Blind, Placebo-Controlled Multicentre Study to Evaluate the Efficacy and Safety of MBP8298 in Subjects with Secondary Progressive Multiple Sclerosis. Tony Traboulsee Neurology 2004
fMRI Somatotopy of Speech Motor Cortex Elton Ngan Psychiatry 2004
fMRI A combined fMRI/DTI analysis of the cerebral motion pathways. Jason Barton Opthamology 2004
MRI Neuropsychological and neuropathological effects of acute vs chronic alcohol consumption: Outcome from traumatic brain injury Rael Lange Riverview 2004
MRI Evaluation of delayed gadolinium enhanced magnetic resonance imaging (dGEMRIC) as a more sensitive measure of intervertebral disc degeneration. David Wilson Orthopaedic Engineering 2004
fMRI Using real-time fMRI feedback in patients with recurrent unipolar depression Kalina Christoff Psychology 2004
fMRI Working memory representations at different levels of abstraction: an fMRI investigation Kalina Christoff Psychology 2004
fMRI Attention in a Dynamic World: Influences of the Optic Flow Field on Visuospatial Attention Todd Handy Psychology 2004
fMRI The Neural Basis of Vocal Imitation Steven Brown SFU 2004
fMRI Low-level and High-level Motion Processing in Amblyopic Children Deborah Giaschi Opthamology 2004
fMRI Functional Neuroimaging of the Frontal Lobe during Cognitive Flexibility Tasks Elton Ngan, Todd Woodward Riverview 2004
MRI Effects of hydration status on magnetic resonance imaging measurements of brain volume and water content. Tony Traboulsee Neurology 2004
MRI New Imaging and Diagnostic Modalities: A Novel Quantitative Magnetic Resonance Imaging Technique for the Assessment of Cervical Spondylotic Myelopathy Armin Curt Neurology 2004
fMRI Mapping networks subserving sequential and associative decision making processes Elton Ngan Psychiatry 2004
fMRI Working memory representations at different levels of abstraction: an fMRI investigation Kalina Christoff Psychology 2004
fMRI Compensatory Brain Activation after Stroke Lara Boyd Rehabilitation Sciences 2004
fMRI Force Production in individuals with stroke or spinal cord injury using functional magnetic resonance imaging Janice Eng Rehabilitation Sciences 2004
fMRI The Effect of Resistance Training on Cognitive Performance, Cortical Plasticity, and Fall Risk in Women Aged 65 to 75 Yead Old: A 12-Month Randomized Controlled Trial Teresa Ambrose, Todd Handy Rehabilitation Sciences 2004
fMRI Investigating prefrontal cortex functions using real-time fMRI Kalina Christoff Psychology 2004
fMRI An fMRI Investigation of Rest Kalina Christoff Psychology 2004
fMRI The neural basis of deductive reasoning errors in schizophrenia Elton Ngan Psychiatry 2004
fMRI Topographical Disorientation in Brain Damaged Patients. Jason Barton Opthamology 2004
MRI Sequence Development for Musculoskeletal Applications in the Knee and Hip David Wilson Orthopaedic Engineering 2004
MRI Effect of acetabular labral tears, repair and resection on hip cartilage loading: A 7T MR study David Wilson Orthopaedic Engineering 2004
MRI Monitoring stereotactic radiotherapy treatment of acoustic neuromas Stefan Reinsberg Physics and Astronomy 2004
MRI Axial Strain Estimation in Tissue Phantoms Dinesh Pai Computer Science 2004
MRI The effect of infection following ACL reconstruction on cartilage health David Wilson Orthopaedic Engineering 2004
MRI Dividing the undivided: Cardiac dynamics of leatherback and green turtles David Jones Zoology 2004
MRI Impaction allografting - MR imaging for the bone cement morphology in a cadaveric femur model Tom Oxland Orthopaedic Engineering 2004
fMRI Multi-Site Pediatric Network for fMRI Mapping in Childhood Epilepsy Bruce Bjornson Neurology 2004
MRI Characterising Myelination in Multiple Sclerosis Alex MacKay Radiology 2004
MRI In vivo electrophysiological evaluation of DTI depiction of the deep seated principle motor pathways in human brain. A clinical 3T mRI and functional sterotaxy study Chris Honey Neurology 2004
fMRI Neurological Changes with Motor Learning Nicola Hodges Human Kinetics 2004
MRI Early Hip Osteoarthritis MRI Pilot: dGEMRIC Substudy Jolanda Cibere Rheumatology 2004
MRI Protocol Development for Diffusion Tensor Imaging of the Human Forearm Dinesh Pai Computer Science 2004
MRI Neuropsychological and neuropathological effects of acute versus chronic alcohol consumption on outcome of traumatic brain injury Rael Lange Riverview 2004
fMRI The cortical basis of motion perception deficits in amblyopia Debbie Giaschi Opthamology 2004
MRI TRACK-HD Blair Levitt Neurology 2004
fMRI The cortical basis of reading and temporal processing deficits in dyslexia Debbie Giaschi Opthamology 2004
fMRI Does cortical stimulation facilitate motor learning after stroke? Lara Boyd Rehabilitation Sciences 2004
MRI Alasdair Barr Psychiatry 2004
fMRI The Neuronal Basis of Developmental Stuttering Mario Liotti SFU Psychology 2004
fMRI An NMR Investigation of Pedophilia Kalina Christoff Psychology 2004
MRI Dynamic 3D upper airway modeling of the effect of oral appliances for the treatment of obstructive sleep apnea/hypopnea John Fleetham Respiratory Medicine 2004
fMRI Recovery after stroke: what is the role of the undamaged, contralesional cortex? Lara Boyd Rehabilitation Sciences 2004
MRI Which white matter tracts are involved in distinct psychiatric and surgically treated disorders ? Chris Honey Neurology 2004
fMRI The neural basis of deductive reasoning errors in schizophrenia: Conflict and emotion Elton Ngan Psychiatry 2004
fMRI Integration of disconfirmatory evidence in pychosis: Cognitive and Neural findings Todd Woodward Psychiatry 2004
Study MN43964 (Olero) is a single-arm, open-label extension (OLE), rollover study of ocrelizumab that allows for participants in Parent studies to continue treatment with ocrelizumab and thereby, aims at the continuation of collecting long-term safety and efficacy data.
Idiopathic Normal Pressure Hydrocephalus is a condition of over- accumulation of cerebrospinal fluid (CSF) commonly seen in the elderly and of unknown cause, with current treatment paradigms involving surgical interventions such as shunting the CSF from the ventricles in the brain to the peritoneum in the abdomen. The current literature surrounding INPH has been insufficient and there remains a need for a placebo controlled study. The Placebo-Controlled Effectiveness in INPH Shunting (PENS) trial is a multi-centre blinded, randomized, placebo-controlled design investigation of CSF shunt surgery.
The aim of this work is to identify biomarkers to predict who will respond to interventions involving inhibitory brain stimulation after stroke, and generate new knowledge related to our understanding of the mechanisms of inhibitory brain stimulation. While inhibitory brain stimulation shows promise in promoting recovery after stroke when paired with motor practice, its response is variable: we do not know how stroke-related factors influence its subsequent impact on motor-related brain activity. By employing task-based functional magnetic resonance imaging pre and post stimulation, the current study will examine the impact of inhibitory brain stimulation on motor-related brain activity after stroke.
The purpose of this study is to evaluate effects of a multimodal intervention in healthy older adults and elucidate mechanisms driving associated changes. Participants will take part in a 6 month intervention involving exercise, mindfulness, and nutrition. The comprehensive assessment will focus on: cognition, inflammation, microbiome diversity, sleep quality, neurological imaging markers, fitness, cardiovascular health, and well-being. This assessment will: 1) Help us understand the mechanisms behind the benefits of this intervention and any interactive effects and 2) to serve as a normative dataset for replication in clinical populations.
The CLSA Healthy Brains, Healthy Aging Initiative is a six-year study, funded by the Weston Family Foundation, that will create new datasets to enhance the CLSA database and facilitate independent research into the link between lifestyle, the human microbiome, and brain health. The study will involve 6,000 research participants enrolled in the CLSA, including more than 2,500 who will undergo magnetic resonance imaging (MRI) to monitor brain structure and function as they age. The resulting standardized datasets will be available for use by approved public-sector researchers in Canada and internationally.
CoVasc-ICH Optional MRI Sub-Study enrolls interested participants from the main CoVasc-ICH study. This sub-study will try to determine the effects of colchicine on perihematomal edema formation and remote diffusion weighted imaging lesions on MRI.
In this study, Parkinson’s Disease subjects perform a simple motor task, while they receive subthreshold Electrical Vestibular Stimulation (EVS), and we simultaneously record motor vigour, fMRI and EEG. Different “calibration” stimuli will be delivered in the scanner, and the resultant recordings will be used to train a model to predict vigour from an arbitrary set of stimulation parameters. Precision designed EVS will be later tested outside of the scanner to see if this results in clinically-relevant enhancements in motor task performance.
The ACQUIRE study designed to assess the feasibility data collection in multiple domains (Cerebral Blood Flow using transcranial Doppler, biomarkers of neurologic injury, electroencephalography and neuroimaging). In addition, we are seeking to determine the feasibility of clinical outcome assessment and neuroimaging at 6-months.
This study aims to advance our understanding of why memory problems often persist after concussion, after the brain has seemingly healed. We will be collecting MRI data to confirm that memory complaints after concussion are not directly related to measures of traumatic brain pathology, including corpus callosum white matter integrity and microbleeds. Using resting state fMRI, we will also investigate functional connectivity between the salience network and memory system in the brain in individuals with memory complaints after concussion and those without such complaints to determine whether differences between groups are observable at the level of brain function.
In this study, we will ask our previous volunteers with MS to return 4 years after their original visit so we can collect additional physical, cognitive and myelin MRI data. We will explore whether the amount of myelin at the beginning of the study can predict changes in disability. We will also use new MRI tools to determine what other biological changes, in addition to myelin damage, are linked to progression. Understanding the link between biological changes (in particular myelin) and physical and cognitive changes will allow these more specific imaging methods to be used in clinical trials trying to slow myelin damage and progression.
While MRI excels at for detailed images of soft tissue lesions, including those due to traumatic brain injury, it difficult to use MRI to characterize damage to the bone. Ultrashort echo time (UTE) pulse sequences enable the acquisition of signal from tissues with short T2 relaxation time, but they overall scan times tend to be very long due to inefficiencies elsewhere in the sequence. This work aims to develop novel, optimized RF pulse sequences by employing novel MB prepulses.
A study to evaluate the efficacy and safety of fenebrutinib on disability progression in adult participants with Primary Progressive Multiple Sclerosis (PPMS). All eligible participants will be randomly assigned to either daily oral fenebrutinib (or placebo) or intravenous (IV) ocrelizumab (or placebo).
This study will evaluate if relapsing-remitting MS patients that have not had a relapse in the past year would benefit from a switch to ofatumumab versus staying on their continued current therapy. This study will also look at whether an elevated serum neurofilament light (NfL) level predicts enhanced benefit from a switch to ofatumumab.
This study involves testing advanced MRI techniques (myelin water imaging, inhomogeneous magnetization transfer and diffusion imaging) to measure changes in the spinal cord after spinal cord injury. In this first stage we will optimize these techniques for spinal cord scanning on our 3T scanner and determine reproducibility for white and grey matter regions of interest.
This study will investigate the safety and effectiveness of simufilam with those in placebo, in participants who are diagnosed with mild to moderate Alzheimer disease.
Simufilam is an oral drug meant to restore the normal shape and function of a brain protein called filamin A (FLNA). In patients with Alzheimer disease, the shape of FLNA is distorted. This triggers toxic signaling beta amyloid, and ultimately results in brain cell degeneration and inflammation.
People who have elevated brain amyloid levels may be at risk for or at the earliest stages of Alzheimer’s disease because they have signs of one of two core pathologies of Alzheimer’s disease (abeta amyloid or herein simply “amyloid”), although they do not have symptoms.
The purpose of Study WN42444 is to compare the effects, good or bad, of gantenerumab with those of placebo in participants who are cognitively unimpaired and have elevated levels of amyloid protein in the brain.
Gantenerumab is a man-made antibody that attaches to amyloid in the brain and mobilizes the immune system to remove it.
Prior work suggests that emotion not only alters memory for emotional content per se but can also alter memory for and attitudes towards associated experiences, a process known as transfer of valence. The neural correlates of these effects, however, have yet to be thoroughly investigated. To help us gain a better understanding of how emotion affects transfer of valence, we will ask participants to study pairs of images: one object (always neutral) and one scene (negative or neutral). We will then have participants complete a test phase where they will rate the pleasantness of the neutral objects followed by a memory task to determine memory for the pairings in each condition (negative vs. neutral).
Physical activity is a necessity for healthy living and dependent on the delivery of oxygen to the working muscles to generate energy. Our understanding of the body’s response to physical activity has primarily been characterized using the “typical 70-kg man”, yet substantial sex-differences in the lungs, heart, blood vessels, blood, and muscle may lead men and women to use different mechanisms to deliver oxygen and produce energy during activity. Our study will investigate these differences with a focus on various muscle characteristics including quantity, structure, fibre type, and respiratory capacity.
MDD poses a great economic burden on the health care system due to its long-term disability with a low ability to participate in everyday activities. We aim to understand the mechanism of action of rTMS in clinical practice, improve the targeting of this treatment avenue using functional MRI scans, and investigate novel markers, such as heart rate variability, as an indication of treatment response. https://ninet.med.ubc.ca/research/
Transoral robotic surgery has the potential to provide better surgery outcome to patients with early-stage oropharyngeal SCC, and advances in image guidance during this procedure can optimize resection margins, as well as reduce the risk of complications such as neurovascular injury. The objective of our study is to assess the utility of using 3D transcervical ultrasound to assess oropharyngeal anatomy and pathology and the feasibility of ultrasound-MRI registration for intraoperative image guidance.
(Short title: Sensorimotor imaging & learning [SMiLE]).
The sensorimotor imaging & learning (SMiLE) study will evaluate how oculomotor control contributes to implicit motor sequence learning in healthy, young and older adults. Participants will practice a novel skilled reaching task for 3 days and undergo structural and functional magnetic resonance imaging before and after training. We will investigate change in brain connectivity associated with motor sequence learning. Our findings will contribute to better understanding of the underlying mechanisms contributing to skill learning in healthy adults.
We want to investigate how emotional distractions around us can influence how we see and interact with other non-emotional objects arounds us. Specifically, we want to understand information presented to different senses (e.g., vision, audition) impacts our spatial awareness of the environment. We will utilize specialized behavioral tasks and powerful MRI scanners to help us uncover the underlying patterns of brain activity that guides our attention and action when we are emotionally stimulated.
Altered patterns of avoidance behaviours – which entail taking or withholding action to prevent unpleasant outcomes – are a feature of anxiety and depression; however, we only have a limited understanding of the neural circuits that underpin these behaviours. To address this gap in the literature, we adapt an rodent-based investigation of the neural correlates of avoidance behaviours into a human context (in which participants must learn which stimuli are associated with the need to make or withhold a series of button presses in order to avoid an unpleasant outcome). In particular, we focus on the neural representations of stimuli that signal the appropriate avoidance response to be made and the aversive or neutral outcome of the response to these stimuli.
Most stimulant users also use cannabis. The majority of cannabis users report stress reduction and coping motives for their use; however, there remains little biological evidence of cannabis reducing acute stress. This randomized control clinical drug trial employs a range of methods including biosampling, self-reports, actigraphy, and neuroimaging to examine the effects of cannabinoids on stress response, inhibition, and sleep in cannabis and stimulant co-users.
This study aims to evaluate the correlation of liver elasticity measurements between an investigational ultrasound-based measurement device (Liver Incyte System, manufactured by Sonic Incytes), the standard of care (FibroScan) as well as the non-invasive gold standard (MRE). In addition, this project aims to evaluate the discriminatory ability and investigate cut-offs for different stages of liver disease progression of the Liver Incytes System.
Pairing brain stimulation with rehabilitation after stroke is a promising approach. However, early studies of this intervention responses proved to be highly variable. Some people
showed a strong benefit while others did not. The main aim of the proposed program of research is to identify biomarkers that can be used to predict response to brain stimulation interventions.
www.brain.rehab.med.ubc.ca
This study involves creating a metabolic map of the cingulate gyrus using optimized MRS parameters (sLASER, TR/TE=5000/32ms). We will examine the link between each voxel’s glutamate concentration and pain sensitivity (i.e., pain thresholds and laser evoked potentials). Further, the spatial distribution and variability of all metabolic concentrations will be examined.
This study aims to address the public health problem of concussions and subconcussive head impacts in contact sports such as ice hockey. Our investigation will examine the mechanisms of (sub)concussions on brain function changes with mechanical trauma occurred over multiple hockey seasons. Findings from the study will inform how accumulation of trauma leads to long-term health problems including depression and severe personality change.
Canadian Longitudinal Study on Aging COVID-19 Study: This study will compare brain structure, connectivity, and risk of silent stroke in older persons who have a history or symptoms of COVID-19 compared to older people without a history or symptoms of COVID-19.
This study will investigate the safety and effectiveness of ANAVEX2-73 in people diagnosed with early to mild Alzheimer disease.
Participants will be randomised to receive either high or low dose ANAVEX2-73 or placebo (33% chance) over a period of 48 weeks. The study drug may protect brain neurons (brain nerve cells) that are usually damaged in Alzheimer’s disease, which may enable ANAVEX2-73 to modify AD.
After the screening and baseline visit, participants will return to the Clinic every 3 months for assessments that include cognitive testing, sleep questionnaires, study partner interviews, occasional safety labs, urinalysis and ECG. Outcome measures include regular assessments of cognitive and functional abilities.
The Biogen EMBARK study is an open-label, longitudinal study of the investigational drug aducanumab. The aim of the study is to assess the long-term safety and efficacy of monthly infusions of aducanumab in patients with Alzheimer disease. The study includes magnetic resonance imaging (MRI), positron emission tomography (PET), electrocardiography (ECG), blood sampling, cerebral spinal fluid (CSF) sampling (optional), neuropsychological testing, and caregiver interviews to assess the effects and safety profile of aducanumab.
People with mild vascular cognitive impairment are prone to having little strokes, which can cause changes in cognition over time. Currently there are no treatments for mild vascular cognitive impairment that are approved by Health Canada. This study investigates whether Remote Ischemic Conditioning (cutting off blood flow to a limb temporarily without causing tissue damage) can be implemented successfully by patients, and whether it will improve cognition, brain imaging and blood markers.
The aim of this work is to identify biomarkers to predict who will respond to interventions involving inhibitory brain stimulation after stroke, and generate new knowledge related to our understanding of the mechanisms of inhibitory brain stimulation. While inhibitory brain stimulation shows promise in promoting recovery after stroke when paired with motor practice, its response is variable: we do not know how stroke-related factors influence its subsequent impact on motor-related brain activity. By employing task-based functional magnetic resonance imaging pre and post stimulation, the current study will examine the impact of inhibitory brain stimulation on motor-related brain activity after stroke.
Contribution of phantom MRS data to a multisite B0 drift study lead by researchers at Johns Hopkins University.
This study will permit identification of the key clinical, radiological and serum biomarker related variables predicting clinical deterioration of degenerative cervical myelopathy (DCM) patients. Such knowledge will facilitate improvements in the treatment of DCM, allowing surgeons to provide personalized recommendations depending on expected clinical course.
Our study is attempting to explore the relationship that exists between eye movement patterns, speech patterns, and cognitive decline. This study compares the speech and eye-movements of people with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) to healthy volunteers, to see if there are patterns that can be used to detect Alzheimer’s disease early, and to monitor the progression of Alzheimer’s disease over time.
Link to our study: https://www.vchri.ca/research-study/clinical-data-and-natural-language-processing-early-detection-dementia-canary
Burnout in the medical field has long been recognized as a significant problem. Currently available strategies to reduce burnout and build resilience against it are of limited effectiveness and are highly variable in their outcomes. This research will inform the selection and further development of more effective strategies, by using functional magnetic resonance imaging (fMRI) to provide a strong neuroscientific basis for the selection process.
UBC Cognitive Neuroscience of Thought Laboratory: http://www.christofflab.ca/
The study aims to evaluate sporadic (s-) and familial (f-) frontotemporal lobar degeneration (FTLD) patients and asymptomatic family members of f-FTLD patients, characterizing the cohorts longitudinally and informing clinical trial design. The study has two arms: a “longitudinal arm” involving a comprehensive assessment of clinical, functional, imaging, and biofluid data collection, and a “biofluid-focused arm” involving limited clinical data to accompany biospecimen collection.
Our study aims to enhance our understanding of the impact of Familial Hypdercholesterolemia on tendon health; a highly under-researched area of significant clinical importance. With the use of non-invasive techniques, we aim to examine various determinants of tendon functional recovery in individuals with newly diagnosed Familial Hypdercholesterolemia. This information is fundamental in identifying if current Familial Hypdercholesterolemia treatments methods reverse the functional and structural effect of the lipid accumulation within the tendon.
People frequently experience thoughts which seem to ‘come out of nowhere’, however, the neural underpinnings of this common psychological happening are poorly understood. Using fMRI scanning, we will investigate neural activity in human brains before a thought reaches one’s awareness, once it reaches awareness, during its subsequent elaboration (as a stream of thought), and during its dissipation. Find out more about this research on our laboratory website: http://www.christofflab.ca/
Autoimmune encephalitis (AIE) is a serious condition caused by misdirected immune response against the brain. Magnetic Resonance Imaging (MRI) is used for the detection of brain abnormalities in many neurological conditions but routine MRI studies are normal in the majority of AIE cases, despite the obvious widespread neurological dysfunction. We aim to determine if there is damage to myelin due to widespread inflammation using Myelin Water Imaging (MWI) in AIE patients and if these relate to abnormalities in cognitive testing, serum neurofilament light-chain levels (a blood biomarker of neuronal damage), and retinal measurements obtained by optical coherence tomography.
The purpose of our study is to learn about ‘biomarkers’ (biological features such as proteins, genes, and brain images that indicate the state of a disease in a person), and how they can help predict treatment outcomes in patients with clinical depression. This study involves standard treatment for depression. Patients will be treated by a psychiatrist for 16 weeks with an antidepressant medication approved to treat depression. No placebos are being used.
Adults with Congenital Heart Disease (ACHD) are at increased risk of clinical and silent infarcts as well as dementia. The SEARCH study will be the first prospective cohort study in ACHD patients evaluating silent cerebrovascular disease over time, and how this is associated with cognitive changes and other vascular risk factors. We will evaluate 400 ACHD patients in BC over 3 years using neuroimaging, cognitive testing, and other imaging and bloodwork to try to address these knowledge gaps.
This study looks to compare the use and results of a new ultrasound based measurement device (Liver Incyte, manufactured by Sonic Incytes) to the standard of care (FibroScan) as well as the non-invasive gold standard (MRE). In addition we would like to compare the fat measurement ability of ultrasound attenuation coefficient compared to that of MRI-PDFF.
This randomized control trial is assessing the feasibility and efficacy of an online 16-week intervention employing allocentric spatial navigation tasks to enhance learning and memory capacity and to improve structure and function of the hippocampus following a moderate-severe traumatic brain injury (m-sTBI). Participants will undergo an MR scan, blood collection, and an assessment of behavioural outcomes 7 months and 12 months following a m-sTBI. Participants in the treatment arm complete the online intervention between these time-points while the controls do not.
People living with bipolar disorder often have problems with controlling impulsivity. Using MRI, we will identify subcomponents of response inhibition, a specific form of impulsivity. After, participants will receive 3 rounds of Transcranial Magnetic Stimulation (TMS) to test whether or not we can use it to change impulsivity.
Running is a very popular activity for many adults. However, a diagnosis of knee osteoarthritis is often seen as a “death sentence” for someone’s recreational running career. This study will provide the first evidence to determine the safety of runners for people with degenerative cartilage due to osteoarthritis.
https://mablab.rehab.med.ubc.ca/currentstudies/
Learning how to perform opera is both cognitively and physically demanding, yet some of the students who have been most successful in UBC’s Opera Program have had learning-related disabilities, and appear to have overcome their difficulties, or to have learned compensatory skills that help them not just in opera performance but beyond. The goal of the proposed research is to systematically evaluate and better explain the neural foundations of that observation. In this endeavor, a study is proposed to measure executive function and other learning capabilities before and after a month-long language intensive course that is a required component of UBC opera training, and to determine – through MRI measurement of anatomical changes in fiber tracts in the brain – the neural bases of any observed behavioral improvements.
Canadian Proactive Cohort Study for People Living with Multiple Sclerosis (CanProCo) is an observational study designed to better understand the factors that contribute to MS disease progression using tools from different fields such as epidemiology (i.e. number of patients and distribution of diseases), medical imaging, and immunology (blood). Subjects will participate in annual visits over a 5-year period.
The goals of the study are to investigate whether radiographic FAI and physical activity are risk factors for progression of cartilage damage and other MRI outcomes over 7 years. This study includes a randomly selected population of young adults aged 20-49 with and without hip pain.
This is a 96-week Phase 2 clinical trial for people with mild cognitive impairment to mild Alzheimer disease. The study treatment, an anti-Tau agent, may be able to block soluble tau aggregates, and thereby decrease the spreading of tau pathology in brains with tauopathy. Patients who meet all of the inclusion criteria will receive monthly IV study treatment or placebo for the duration of their enrollment.
LEMCOG Healthy Controls - A prospective 24-month investigator sponsored trial to determine the course of cognitive function and how it relates to MRI measures of structural and functional connectivity in healthy controls across time.
Collection of non-Multiple Sclerosis (MS) untreated control data is invaluable for interpretation of data acquired in MS treatment trials on cognitive outcomes such as memory. Advanced MRI techniques detect differences in the brain between people with and without MS. Understanding differences in brain connection patterns in people without MS helps us to understand the biological changes that may lead to cognitive challenges in MS.
Cerebral small vessel disease (cSVD) is one of the most prevalent neurological disorders and can lead to problems such as dementia or stroke. However, cSVD is usually only discovered on neuroimaging after symptoms develop. We hope to explore the utility of basic bedside assessments (smooth pursuit eye movements and spontaneous speech patterns) as indicators of the presence and severity of underlying cSVD in pre-symptomatic patients.
This study examines the impact of an aerobic exercise intervention on chemotherapy-related cognitive changes (CRCC) in women diagnosed with breast cancer who undergo chemotherapy treatment. The results of this study aim to address the effect and timing of aerobic exercise on CRCC, as well as the outcome of exercise during or following treatment on global measures of brain structure, functioning, and organization through fMRI and EEG assessments.
We propose that injury to the medial forebrain bundle is the cause of the chronic
post-concussive syndrome (PCS). This is a proof of concept study involving a single
subject with PCS following a rotational head injury.
Susac Syndrome, a rare autoimmune disease often misdiagnosed as Multiple Sclerosis, and is a poorly understood disease with no proven treatments. This study will be the first to combine a multidisciplinary evaluation of clinical status and disease activity with advanced imaging metrics. The results will provide pilot data that may broaden our understanding of disease pathogenesis and allow important structural and functional relationships to emerge.
The purpose of this study is to evaluate the efficacy of intranasal oxytocin in reducing social apathy in participants with a diagnosis of Fronto-temporal dementia.
This study explores the cerebrovascular consequences of intermediate (i.e., 1-2 years) and chronic (i.e., >5 years) exposure to daily autonomic dysreflexia in humans with spinal cord injury. We are interested in finding out if the episodic hypertension associated with autonomic dysreflexia impacts cerebrovascular regulation, which plays a role in predisposing this population to cerebral small vessel disease, overt stroke and cognitive decline.
This study will look at the neural basis of the thought dynamics and contents; specifically, the difference between freely moving and deliberately constrained thought, both with and without imagery of spatially anchored scenes. To investigate this, we will combine fMRI and experience sampling.
The current study will examine whether individual differences in neural activation using two fMRI experiments predicts future adherence to physical activity over a 6-month period among adults. The first experiment will examine neural responses to the engagement in inhibitory control. The second experiment will examine neural responses to observing health promotion messages related to physical activity and sedentary behavior.
Detecting the beginning of Alzheimer disease (AD) in the eye by using a noninvasive imaging device that can show amyloid in the retina. This study is an observational, non-treatment study to identify retinal biomarkers associated with AD, and the outcomes measures include 3T MRI, PiB-PET, 3D/2D Retinal Images, Retinal functional tests, and a variety of cognitive and behavioural interviews. The study will assess the efficacy of the device in rodent models and patients with AD, and if successful, the device may lead to better and earlier diagnosis of AD with lower cost.
Exercise Prescription.
In this proposed study, we will study the effects of different types and combinations of exercise training on cognitive function in older adults who are at increased risk for dementia (i.e., mild cognitive impairment). Older adults with mild cognitive impairment represent an ideal target population for intervention strategies, as the preservation of their cognitive function will likely maintain and prolong their ability to live independently and with quality. Furthermore, we will explore how each exercise type improves cognitive function as such information may lead to new discoveries and therapies.
This study will look at the neural basis of the dynamics of thought; particularly, the differences between freely-moving thought and constrained thought. To investigate this, we will combine experience sampling with fMRI.
A Randomized Controlled Double Blind Trial.
Physical exercises, cognitive training, and vitamin D are low cost interventions and have the potential to enhance cognitive and mobility function in older adults, especially in pre-dementia states such as Mild Cognitive Impairment (MCI). Currently, it is unclear whether aerobic, resistance, or tone and stretching exercise would have different effects on cognitive performance. We postulate that combined strength and aerobic training will have a better effect on cognition over tone stretching-control exercise in an MCI population. Additionally, we will assess if a multi-domain intervention including cognitive training and vitamin D will have synergistic efficacy.